Research Article
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Association of Neopterin and Wound Healing Process

Year 2019, Volume: 9 Issue: 2, 65 - 68, 01.08.2019

Abstract

DOI: 10.26650/experimed.2019.19014


Human monocytes/macrophages produce
neopterin when stimulated by the cytokine interferon-γ. The concentration of
neopterin in body fluids such as serum, cerebrospinal fluid and urine can be
measured and increased concentrations of neopterin provides information about
infections states. Nowadays, neopterin is as a marker in neurological and
cardiovascular diseases during cellular immune activation.

Cite this article as: Hepokur C, Mısır S,
Hepokur Aİ, Yaylım İ. Association of Neopterin and Wound Healing Process.
Experimed 2019; 9(2): 65-8.

References

  • 1. Mahmoud RA, El-Gendi HI, Ahmed HH. Serum neopterin, tumor necrosis factor-α and soluble tumor necrosis factor receptor II (p75) levels and disease activity in Egyptian female patients with systemic lupus erythematosus. Clin Biochem 2005; 38: 134-41. [CrossRef] 2. Shady MMA, Fathy HA, Ali A, Youness ER, Fathy GA. Association of neopterin as a marker of immune system activation and juvenile rheumatoid arthritis activity. J Pediatr 2015; 91: 352-7. [CrossRef] 3. Krcmova L, Solichova D, Melichar B, Kasparova M, Plisek J, Sobotka L, et al. Determination of neopterin, kynurenine, trypophan and creatinine in human serum by high throuput HPLC. Talanta 2011; 85: 1466-71. [CrossRef] 4. Zhao Ars H, Yin S, Fan J. High plasma neopterin levels in Chinese children with autism spectrum disorders. Int J Devl Neuroscience 2015; 41: 92-7. [CrossRef] 5. Garcia-Gonzalez MJ, Dominguez-Rodriguez A, Abreu-Gonzalez P. Light -Dark variations in neopterin serum levels in patients with st-segment elevation acute coronary syndrome undergoing primary angioplasty. Rev Esp Cardiol 2008; 61: 1280-6. [CrossRef] 6. Ursavaş A, Karadağ M, Oral AY, Demirdogen E, Oral HB, Ege E. Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea. Respir Med 2008; 102: 1193-7. [CrossRef] 7. Arshadi D, Nikbin B, Shakiba Y, Kiani A, Jamshidi AR, Boroushaki MT. Plasma level of neopterin as a marker of disease activity in treated rheumatoid arthritis patients: Association with gender, disease activity and anti-CCP antibody. Int Immunopharmacol 2013; 17: 763-7. [CrossRef] 8. Ercan N, Tuzcu N, Başbuğ O, Gök K, Işıdan H, Oğrak YZ. Evaluation of important biomarkers in healthy cattle. Kafkas Univ Vet Fak Dergisi 2014; 20: 749-55. [CrossRef] 9. Schroecksnadel K, Frick B, Winkler C, Fuith Lothar C, Fuchs D. Relationship between homocysteine and neopterin concentrationsin patients with gynecological cancer. Cancer Lett 2006; 240: 198-202. [CrossRef] 10. Sipahi H, Becker K, Gostner JM, Charehsaz M, Kırmızıbekmez H, Schennach H, et al. Effects of globularifolin on cell survival, nuclear factor-κB activity, neopterin production, tryptophan breakdown and free radicals in vitro. Fitoterapia 2014; 92: 85-92. [CrossRef] 11. Kaski JC, Consuegra-Sanchez L, Fernandez-Berges DJ, Cruz-Fernandez JM, Garcia-Moll X, Marrugat J, et al. Elevated serum neopterin levels and adverse cardiac events at 6 months follow-up in mediterranean patients with non-ST- segment elevation acute coronary syndrome. Atherosclerosis 2008; 201: 176-83. [CrossRef] 12. Frick B, Schroecksnadel K, Neurauter G, Leblhuber F, Fuchs D. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem 2004; 37: 684-7. [CrossRef] 13. Akbulut HH, Çelik I, Akbulut A, Yuce P, Kiliç SS. Serum neopterin levels in patienets with brucellosis. J Infect 2005; 51: 281-6. [CrossRef] 14. Prat C, Dominguez J, Andreo F, Blanco S, Pallares A, Cuchillo F, et al. Procalcitonin and neopterin correlation with aetiology and severity of pneumonia. J Infect 2006; 52: 169-77. [CrossRef] 15. Pınar O, Ozgur AE, Esragul A, Halil Y, Gulcan KY, Ayşe E, et al. High serum levels of neopterin in patients with Crimenga-Congo hemorrhagic fever and its relation with mortality. J Infect 2008; 56: 366-70. [CrossRef] 16. Stoeck K, Zerr I. Cellular immune activation markers neopterin and beta 2-microglobulin are elevated in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. J Neuroimmunol 2011; 233: 228-32. [CrossRef] 17. Volgger B, Aspisirengil C, Genser-Krimbacher E, Ciresa-Koenig A, Daxenbichler G, Fuchs D, et al. Prognostic significance of TPA versus SCC-Ag, CEA and neopterin in carcinoma of the uterine cervix. Cancer Lett 2008; 262: 183-9. [CrossRef] 18. Köse O, Arca E, Akgül O, Erbil K. The levels of serum neopterin in Behçet’s disease-objective marker of disease activity. J Dermatol Sci 2006; 42: 128-30. [CrossRef] 19. Sucher R, Schroecksnadel K, Weiss G, Margreiter R, Fuchs D, Brandacher G. Neopterin, a prognostic marker in human malignancies. Cancer Lett 2010; 287: 13-22. [CrossRef] 20. Ciprandi G, Amici M, Marseglia G, Fuchs D. Sublingual immunotherapy may affect serum neopterin: preliminary findings. Int Immunopharmacol 2010; 10: 1474-6. [CrossRef] 21. Cesur S, Aslan T, Hoca NT, Çimen F, Tarhan G, Çiftçi A, et al. Clinical importance of serum neopterin level in patients with pulmonary tuberculosis. Int J Mycobacteriol 2014; 3: 5-8. [CrossRef] 22. Castro M, Marco G, Arita D, Teixeira L, Pereira A, Casarini D. Urinary neopterin quantification by reverse-phase high-performance liquid chromatography with ultraviolet detection. J Biochem Biophys Methods 2004; 59: 275-83. [CrossRef] 23. Firth CA, Laing AD, Baird SK, Pearson J, Gieseg SP. Inflammatory sites as a source of plasma neopterin: Measurement of high levels of neopterin and markers of oxidative stress in pus drained from human abscesses. Clin Biochem 2008; 41: 1078-83. [CrossRef] 24. Cano O, Neurauter G, Fuchs D, Shearer G, Boasso A. Different effect of type I and II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells. Neurosci Lett 2008; 438: 22-5. [CrossRef] 25. Baydar T, Yuksel O, Sahin TT, Dikmen K, Girgin G, Sipahi H, et al. Neopterin as a prognostic biomarker in intensive care unit patients. J Crit Care 2009; 24: 318-21. [CrossRef] 26. Flavall E, Crone E, Moore G, Gieseg S. Dissociation of neopterin and 7,8-dihydroneopterin from plasma components before HPLC analysis. J Chromatogr B Analyt Technol Biomed Life Sci 2008; 863: 167-71. [CrossRef] 27. Mommsen P, Frink M, Pape HC, Van Griensven M, Probst C, Gaulke R, et al. Elevated systemic IL-18 and neopterin levels are associated with posttraumatic complications among patients with multiple injuries: a prospective cohort study. Injury 2009; 40: 528-34. [CrossRef] 28. Alber HF, Duftner C, Wanitschek M, Dörler J, Schirmer M, Suessenbacher A, et al. Neopterin, CD4+CD28− lymphocytes and the extent and severity of coronary artery disease. Int J Cardiol 2009; 135: 27-35. [CrossRef] 29. Lyu Y, Jiang X, Dai W. The roles of a novel inflammatory neopterin in subjects with coronary atherosclerotic heart disease. Int Immunopharmacol 2015; 24: 169-72. [CrossRef] 30. Kuehne LK, Reiber H, Bechter K, Hagberg L, Fuchs D. Cerebrospinal fluid neopterin is brain-derived and not associated with blood-CSF barrier dysfunction in non-inflammatory affective and schizophrenic spectrum disorders. J Psychiatr Res 2013; 47: 1417-22. [CrossRef] 31. Yaman H, Cakir E, Ozcan O, Yesilova Z, Ozcan A, Akgul EO, et al. Elevated urine neopterin levels in nonalcoholic steatohepatitis. Clin Biochem 2005; 38: 187-90. [CrossRef] 32. Mehta P, Bruce A, Patrick B, Dalton AJ, Patel B, Mehta SP, et al. Increased serum neopterin levels in adults with Down syndrome. J Neuroimmunol 2005; 164: 129-33. [CrossRef] 33. Ishikawa T, Hamel M, Zhu B, Li D, Michiue D, Maeda H. Comparative evaluation of postmortem serum concentrations of neopterin and C-reactive protein. Forensic Sci Int 2008; 179: 135-43. [CrossRef] 34. Sun Y, He J, Tian J, Xie Z, Wang C, Yu B. Association of circulating levels of neopterin with non-culprit plaque vulnerability in CAD patients an angiogram, optical coherent tomography and intravascular ultrasound study. Atherosclerosis 2015; 241: 138-42. [CrossRef] 35. Frick B, Schroecksnadel K, Neurauter G, Leblhuber F, Fuchs D. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem 2004; 37: 684-7. [CrossRef] 36. Bayram M, Bayram O, Boyunağa H, Ozer G. A research on the level of urine neopterin to see if it may provide a vital clue for a provisional diagnosis of breast cancer in menopausal women. Maturitas 2004; 48: 432-7. [CrossRef] 37. Centi S, Tombelli S, Puntoni M, Domenici C, Franek M, Palchetti I. Detection of biomarkers for inflammatory diseases yan electrochemical immunoassay: The case of neopterin. Talanta 2015; 134: 48-53. [CrossRef] 38. Sugioka K, Naruko T, Hozumi T, Nakagawa M, Kitabayashi C, Ikura Y, et al. Elevated levels of neopterin are associated with carotid plaques with complex morphology in patients with stable angina pectoris. Atherosclerosis 2010; 208: 524-30. [CrossRef] 39. Dominguez-Rodriguez A, Abreu-Gonzalez P, Avanzas P, Laynez-Cerde˜na I, Carlos Kaski J. Neopterin predicts left ventricular remodeling in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Atherosclerosis 2010; 211: 574-8. [CrossRef] 40. Razumovitch J, Fuchs D, Semenkova G, Cherenkevich S. Influence of neopterin on generation of reactive species by myeloperoxidase in human neutrophils. Biochimica et Biophysica Acta 2004; 1672: 46-50. [CrossRef] 41. Schulz KF, Altman DG, Moher D. Consort 2010 statement: updated guidelines for reporting parallel group randomised trials. Deutsche Medizinische Wochenschrift 2011; 136: e26 [CrossRef]

Neopterin ve Yara İyileşme Süreci İlişkisi

Year 2019, Volume: 9 Issue: 2, 65 - 68, 01.08.2019

Abstract

DOI: 10.26650/experimed.2019.19014


İnsan monositleri/makrofajları, sitokin
interferon-γ tarafından uyarıldığında neopterin üretir. Serum, beyin omurilik
sıvısı ve idrar gibi vücut sıvılarında neopterinin konsantrasyonu ölçülebilir
ve artan neopterin konsantrasyonları enfeksiyon durumları hakkında bilgi
sağlar. Günümüzde neopterin, hücresel immün aktivasyonu sırasındaki nörolojik
ve kardiyovasküler hastalıklarda bir belirteç olarak kullanılır.

Cite this article as: Hepokur C, Mısır S,
Hepokur Aİ, Yaylım İ. Association of Neopterin and Wound Healing Process.
Experimed 2019; 9(2): 65-8.

References

  • 1. Mahmoud RA, El-Gendi HI, Ahmed HH. Serum neopterin, tumor necrosis factor-α and soluble tumor necrosis factor receptor II (p75) levels and disease activity in Egyptian female patients with systemic lupus erythematosus. Clin Biochem 2005; 38: 134-41. [CrossRef] 2. Shady MMA, Fathy HA, Ali A, Youness ER, Fathy GA. Association of neopterin as a marker of immune system activation and juvenile rheumatoid arthritis activity. J Pediatr 2015; 91: 352-7. [CrossRef] 3. Krcmova L, Solichova D, Melichar B, Kasparova M, Plisek J, Sobotka L, et al. Determination of neopterin, kynurenine, trypophan and creatinine in human serum by high throuput HPLC. Talanta 2011; 85: 1466-71. [CrossRef] 4. Zhao Ars H, Yin S, Fan J. High plasma neopterin levels in Chinese children with autism spectrum disorders. Int J Devl Neuroscience 2015; 41: 92-7. [CrossRef] 5. Garcia-Gonzalez MJ, Dominguez-Rodriguez A, Abreu-Gonzalez P. Light -Dark variations in neopterin serum levels in patients with st-segment elevation acute coronary syndrome undergoing primary angioplasty. Rev Esp Cardiol 2008; 61: 1280-6. [CrossRef] 6. Ursavaş A, Karadağ M, Oral AY, Demirdogen E, Oral HB, Ege E. Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea. Respir Med 2008; 102: 1193-7. [CrossRef] 7. Arshadi D, Nikbin B, Shakiba Y, Kiani A, Jamshidi AR, Boroushaki MT. Plasma level of neopterin as a marker of disease activity in treated rheumatoid arthritis patients: Association with gender, disease activity and anti-CCP antibody. Int Immunopharmacol 2013; 17: 763-7. [CrossRef] 8. Ercan N, Tuzcu N, Başbuğ O, Gök K, Işıdan H, Oğrak YZ. Evaluation of important biomarkers in healthy cattle. Kafkas Univ Vet Fak Dergisi 2014; 20: 749-55. [CrossRef] 9. Schroecksnadel K, Frick B, Winkler C, Fuith Lothar C, Fuchs D. Relationship between homocysteine and neopterin concentrationsin patients with gynecological cancer. Cancer Lett 2006; 240: 198-202. [CrossRef] 10. Sipahi H, Becker K, Gostner JM, Charehsaz M, Kırmızıbekmez H, Schennach H, et al. Effects of globularifolin on cell survival, nuclear factor-κB activity, neopterin production, tryptophan breakdown and free radicals in vitro. Fitoterapia 2014; 92: 85-92. [CrossRef] 11. Kaski JC, Consuegra-Sanchez L, Fernandez-Berges DJ, Cruz-Fernandez JM, Garcia-Moll X, Marrugat J, et al. Elevated serum neopterin levels and adverse cardiac events at 6 months follow-up in mediterranean patients with non-ST- segment elevation acute coronary syndrome. Atherosclerosis 2008; 201: 176-83. [CrossRef] 12. Frick B, Schroecksnadel K, Neurauter G, Leblhuber F, Fuchs D. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem 2004; 37: 684-7. [CrossRef] 13. Akbulut HH, Çelik I, Akbulut A, Yuce P, Kiliç SS. Serum neopterin levels in patienets with brucellosis. J Infect 2005; 51: 281-6. [CrossRef] 14. Prat C, Dominguez J, Andreo F, Blanco S, Pallares A, Cuchillo F, et al. Procalcitonin and neopterin correlation with aetiology and severity of pneumonia. J Infect 2006; 52: 169-77. [CrossRef] 15. Pınar O, Ozgur AE, Esragul A, Halil Y, Gulcan KY, Ayşe E, et al. High serum levels of neopterin in patients with Crimenga-Congo hemorrhagic fever and its relation with mortality. J Infect 2008; 56: 366-70. [CrossRef] 16. Stoeck K, Zerr I. Cellular immune activation markers neopterin and beta 2-microglobulin are elevated in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. J Neuroimmunol 2011; 233: 228-32. [CrossRef] 17. Volgger B, Aspisirengil C, Genser-Krimbacher E, Ciresa-Koenig A, Daxenbichler G, Fuchs D, et al. Prognostic significance of TPA versus SCC-Ag, CEA and neopterin in carcinoma of the uterine cervix. Cancer Lett 2008; 262: 183-9. [CrossRef] 18. Köse O, Arca E, Akgül O, Erbil K. The levels of serum neopterin in Behçet’s disease-objective marker of disease activity. J Dermatol Sci 2006; 42: 128-30. [CrossRef] 19. Sucher R, Schroecksnadel K, Weiss G, Margreiter R, Fuchs D, Brandacher G. Neopterin, a prognostic marker in human malignancies. Cancer Lett 2010; 287: 13-22. [CrossRef] 20. Ciprandi G, Amici M, Marseglia G, Fuchs D. Sublingual immunotherapy may affect serum neopterin: preliminary findings. Int Immunopharmacol 2010; 10: 1474-6. [CrossRef] 21. Cesur S, Aslan T, Hoca NT, Çimen F, Tarhan G, Çiftçi A, et al. Clinical importance of serum neopterin level in patients with pulmonary tuberculosis. Int J Mycobacteriol 2014; 3: 5-8. [CrossRef] 22. Castro M, Marco G, Arita D, Teixeira L, Pereira A, Casarini D. Urinary neopterin quantification by reverse-phase high-performance liquid chromatography with ultraviolet detection. J Biochem Biophys Methods 2004; 59: 275-83. [CrossRef] 23. Firth CA, Laing AD, Baird SK, Pearson J, Gieseg SP. Inflammatory sites as a source of plasma neopterin: Measurement of high levels of neopterin and markers of oxidative stress in pus drained from human abscesses. Clin Biochem 2008; 41: 1078-83. [CrossRef] 24. Cano O, Neurauter G, Fuchs D, Shearer G, Boasso A. Different effect of type I and II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells. Neurosci Lett 2008; 438: 22-5. [CrossRef] 25. Baydar T, Yuksel O, Sahin TT, Dikmen K, Girgin G, Sipahi H, et al. Neopterin as a prognostic biomarker in intensive care unit patients. J Crit Care 2009; 24: 318-21. [CrossRef] 26. Flavall E, Crone E, Moore G, Gieseg S. Dissociation of neopterin and 7,8-dihydroneopterin from plasma components before HPLC analysis. J Chromatogr B Analyt Technol Biomed Life Sci 2008; 863: 167-71. [CrossRef] 27. Mommsen P, Frink M, Pape HC, Van Griensven M, Probst C, Gaulke R, et al. Elevated systemic IL-18 and neopterin levels are associated with posttraumatic complications among patients with multiple injuries: a prospective cohort study. Injury 2009; 40: 528-34. [CrossRef] 28. Alber HF, Duftner C, Wanitschek M, Dörler J, Schirmer M, Suessenbacher A, et al. Neopterin, CD4+CD28− lymphocytes and the extent and severity of coronary artery disease. Int J Cardiol 2009; 135: 27-35. [CrossRef] 29. Lyu Y, Jiang X, Dai W. The roles of a novel inflammatory neopterin in subjects with coronary atherosclerotic heart disease. Int Immunopharmacol 2015; 24: 169-72. [CrossRef] 30. Kuehne LK, Reiber H, Bechter K, Hagberg L, Fuchs D. Cerebrospinal fluid neopterin is brain-derived and not associated with blood-CSF barrier dysfunction in non-inflammatory affective and schizophrenic spectrum disorders. J Psychiatr Res 2013; 47: 1417-22. [CrossRef] 31. Yaman H, Cakir E, Ozcan O, Yesilova Z, Ozcan A, Akgul EO, et al. Elevated urine neopterin levels in nonalcoholic steatohepatitis. Clin Biochem 2005; 38: 187-90. [CrossRef] 32. Mehta P, Bruce A, Patrick B, Dalton AJ, Patel B, Mehta SP, et al. Increased serum neopterin levels in adults with Down syndrome. J Neuroimmunol 2005; 164: 129-33. [CrossRef] 33. Ishikawa T, Hamel M, Zhu B, Li D, Michiue D, Maeda H. Comparative evaluation of postmortem serum concentrations of neopterin and C-reactive protein. Forensic Sci Int 2008; 179: 135-43. [CrossRef] 34. Sun Y, He J, Tian J, Xie Z, Wang C, Yu B. Association of circulating levels of neopterin with non-culprit plaque vulnerability in CAD patients an angiogram, optical coherent tomography and intravascular ultrasound study. Atherosclerosis 2015; 241: 138-42. [CrossRef] 35. Frick B, Schroecksnadel K, Neurauter G, Leblhuber F, Fuchs D. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem 2004; 37: 684-7. [CrossRef] 36. Bayram M, Bayram O, Boyunağa H, Ozer G. A research on the level of urine neopterin to see if it may provide a vital clue for a provisional diagnosis of breast cancer in menopausal women. Maturitas 2004; 48: 432-7. [CrossRef] 37. Centi S, Tombelli S, Puntoni M, Domenici C, Franek M, Palchetti I. Detection of biomarkers for inflammatory diseases yan electrochemical immunoassay: The case of neopterin. Talanta 2015; 134: 48-53. [CrossRef] 38. Sugioka K, Naruko T, Hozumi T, Nakagawa M, Kitabayashi C, Ikura Y, et al. Elevated levels of neopterin are associated with carotid plaques with complex morphology in patients with stable angina pectoris. Atherosclerosis 2010; 208: 524-30. [CrossRef] 39. Dominguez-Rodriguez A, Abreu-Gonzalez P, Avanzas P, Laynez-Cerde˜na I, Carlos Kaski J. Neopterin predicts left ventricular remodeling in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Atherosclerosis 2010; 211: 574-8. [CrossRef] 40. Razumovitch J, Fuchs D, Semenkova G, Cherenkevich S. Influence of neopterin on generation of reactive species by myeloperoxidase in human neutrophils. Biochimica et Biophysica Acta 2004; 1672: 46-50. [CrossRef] 41. Schulz KF, Altman DG, Moher D. Consort 2010 statement: updated guidelines for reporting parallel group randomised trials. Deutsche Medizinische Wochenschrift 2011; 136: e26 [CrossRef]
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Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Ceylan Hepokur

Sema Mısır This is me

Ali İhsan Hepokur This is me

İlhan Yaylım This is me

Publication Date August 1, 2019
Submission Date July 20, 2019
Published in Issue Year 2019 Volume: 9 Issue: 2

Cite

Vancouver Hepokur C, Mısır S, Hepokur Aİ, Yaylım İ. Association of Neopterin and Wound Healing Process. Experimed. 2019;9(2):65-8.