Obesity and Gastrointestinal Regulation of Food Intake

Year 2024, Volume: 3 Issue: 1, 37 - 42, 30.03.2024

Öznur Demirtaş , Ayşegül Sümer

https://doi.org/10.59518/farabimedj.1328565

Abstract

The aim in this review is to explain the role of the gastrointestinal system in obesity and related complications by focusing on the biological mechanisms between obesity and the gastrointestinal system, based on the latest evidence in the literature. A systematic search of the literatures in the PubMed and ScienceDirect databases was conducted. Factors such as inflammation, mechanical space-occupying effect, microbiota, and adipocyte peptides are involved the development of obesity-related gastrointestinal system comorbidities. However, obesity occurs when the connection between the gastrointestinal tract and the brain changes. Signaling dysfunction disrupts the brain-gut axis, leading to increased frequency of food intake and excessive fat accumulation. Obesity increases the risk of developing gastrointestinal system disorders. However, the gastrointestinal tract and its pathophysiology play a key role the regulation of food intake and subsequent progression to obesity.

Keywords

Brain-gut axis, Food intake, Gastrointestinal system, Obesity

Obezite ve Gıda Alımının Gastrointestinal Düzenlenmesi

Abstract

Bu derlemedeki amaç, obezite ve gastrointestinal sistem arasındaki biyolojik mekanizmalara odaklanarak literatürdeki en son kanıtlara dayanarak gastrointestinal sistemin obezite ve ilişkili komplikasyonlardaki rolünü açıklamaktır. PubMed ve ScienceDirect veri tabanlarındaki literatürlerin sistematik bir taraması yapılmıştır. Obezite ile ilişkili gastrointestinal sistem komorbiditelerin gelişmesinde inflamasyon, mekanik olarak yer kaplayan etki, mikrobiyota, adiposit peptitler gibi faktörler yer almaktadır. Bununla birlikte gastrointestinal sistem ve beyin arasındaki bağlantı değiştiğinde obezite ortaya çıkmaktadır. Sinyal verme disfonksiyonu, beyin-bağırsak eksenini bozarak, artan gıda alım sıklığına ve aşırı yağ birikimine yol açmaktadır. Obezite, gastrointestinal sistem bozukluklarını geliştirme riskini artırmaktadır. Bununla birlikte gastrointestinal sistem ve patofizyolojisi, gıda alımının düzenlenmesinde ve ardından obeziteye doğru ilerlemede anahtar rol oynamaktadır.

Keywords

Beyin-bağırsak ekseni, Gastrointestinal sistem, Gıda alımı, Obezite

References

• Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375-C391. doi:10.1152/ajpcell.00379.2020
• Lustig RH, Collier D, Kassotis C, et al. Obesity I: Overview and molecular and biochemical mechanisms. Biochem Pharmacol. 2022;199:115012. doi:10.1016/j.bcp.2022.115012
• Calderón, G, Acosta A. The Gastrointestinal System and Obesity. Dietary Interventions in Gastrointestinal Diseases 2019;43-62. doi:10.1016/B978-0-12-814468-8.00004-1
• Foxx-Orenstein AE. Gastrointestinal symptoms and diseases related to obesity: an overview. Gastroenterol Clin North Am. 2010;39(1):23-37. doi:10.1016/j.gtc.2009.12.006
• Emerenziani S, Guarino MPL, Trillo Asensio LM, et al. Role of Overweight and Obesity in Gastrointestinal Disease. Nutrients. 2019;12(1):111. Published 2019 Dec 31. doi:10.3390/nu12010111
• Purnell JQ. Definitions, Classification, and Epidemiology of Obesity. In: Feingold KR, Anawalt B, Blackman MR, et al., eds. Endotext. South Dartmouth (MA): MDText.com, Inc.; May 4, 2023.
• Türkiye Endokrinoloji ve Metabolizma Derneği (TEMD). Obezitenin Önemi, Epidemiyolojik Veriler ve Patogenez. Obezite Tanı ve Tedavi Kılavuzu 2018;11-19.
• Tack J, Verbeure W, Mori H, et al. The gastrointestinal tract in hunger and satiety signalling. United European Gastroenterol J. 2021;9(6):727-734. doi:10.1002/ueg2.12097
• Duca FA, Sakar Y, Covasa M. The modulatory role of high fat feeding on gastrointestinal signals in obesity. J Nutr Biochem. 2013;24(10):1663-1677. doi:10.1016/j.jnutbio.2013.05.005
• Kohan AB, Wang F, Lo CM, Liu M, Tso P. ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety. Am J Physiol Gastrointest Liver Physiol. 2015;308(6):G472-G481. doi:10.1152/ajpgi.00098.2014
• Saka M, Köseler E, Metin S. Gastrointestinal Sistem Hastalıkları ve Beslenme Tedavisi. İçinde: Tüfekçi Alphan E ed. Hastalıklarda Beslenme Tedavisi. 1.Baskı. Ankara, Hatipoğlu; 2013;541-639.
• Asadi A, Shadab Mehr N, Mohamadi MH, et al. Obesity and gut-microbiota-brain axis: A narrative review. J Clin Lab Anal. 2022;36(5):e24420. doi:10.1002/jcla.24420
• Frihauf JB, Zorrilla EP, Fekete EM. Control of Food Intake. Encyclopedia of Behavioral Neuroscience 2010; 335–344. doi: 10.1016/B978-0-08-045396-5.00164-0
• Lv Y, Liang T, Wang G, Li Z. Ghrelin, a gastrointestinal hormone, regulates energy balance and lipid metabolism. Biosci Rep. 2018;38(5):BSR20181061. Published 2018 Sep 25. doi:10.1042/BSR20181061
• Zhu W, Tanday N, Flatt PR, Irwin N. Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes. Peptides. 2023;160:170923. doi:10.1016/j.peptides.2022.170923
• Andersen DB, Holst JJ. Peptides in the regulation of glucagon secretion. Peptides. 2022;148:170683. doi:10.1016/j.peptides.2021.170683
• Cifuentes L, Camilleri M, Acosta A. Gastric Sensory and Motor Functions and Energy Intake in Health and Obesity-Therapeutic Implications. Nutrients. 2021;13(4):1158. Published 2021 Apr 1. doi:10.3390/nu13041158
• Zeng Q, Ou L, Wang W, Guo DY. Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes. Front Endocrinol (Lausanne). 2020;11:112. Published 2020 Mar 6. doi:10.3389/fendo.2020.00112
• Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. 2018;159(12):3874-3884. doi:10.1210/en.2018-00672
• Woźniak D, Cichy W, Przysławski J, Drzymała-Czyż S. The role of microbiota and enteroendocrine cells in maintaining homeostasis in the human digestive tract. Adv Med Sci. 2021;66(2):284-292. doi:10.1016/j.advms.2021.05.003