Pemfigus Tedavisinde Rituksimab Kullanımı

Year 2017, Volume: 2 Issue: 2, 34 - 48, 25.10.2017

Bengü Gerçeker Türk , Ecem Bulut

Abstract

Rituksimab  matür B hücrelerinin yüzeyinde bulunan CD20 antijenine bağlanan, sitolitik etkili, Ig G yapısında, kimerik, monoklonal bir antikordur. Rituksimab non-Hodgkin lenfoma, kronik lenfositik lösemi, romatoid artrit, mikroskobik polianjitis ve granülomatöz polianjitis (Wegener Granülomatozu’nda) tedavisinde endikedir.  Günümüzde çok sayıda otoimmün hastalık tedavisinde ve  2001 yılından beri de pemfigusta kullanılmaktadır.  Pemfigus tedavi rehberlerinde şimdilik üçüncü basamak tedavi ajanı olarak karşımıza çıkan rituksimab yakın gelecekte pemfigusun birinci basamak tedavisinde yerini alacak gibi gözükmektedir.  Bu derlemede güncel bilgiler ışığında pemfiguslu olgularda rituksimab kullanımı ile ilgili veriler ve kullanım ilkeleri ele alınmıştır. 

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