Erken Evre Karaciğer Fibrozisini Öngörmede Shear Wave Elastografinin Rolü

Year 2024, , 65 - 70, 29.02.2024

Mehmet Karagülle , Fatma Zeynep Arslan , Mehmet Semih Çakır , Abdullah Soydan Mahmutoğlu , Ayşe İnci

https://doi.org/10.54005/geneltip.1346937

Abstract

Amaç: Çalışmamızda ultrason shear wave elastografi (SWE) değerleri ile histopatolojik sonuçlar arasındaki ilişkiyi inceledik. Böylece, SWE'nin erken fibrozu göstermedeki duyarlılığını değerlendirdik.
Materyal ve Metod: Kronik hepatit B hastalığına sahip ardışık 70 hasta prospektif olarak değerlendirildi. Ishak skorlamasına göre fibroz evreleri (F) 0, 1, 2, 3 ve 4'e dahil edilen hastalar SWE ile incelendi. Erken evre fibroz tespit edilen F2, F3 ve F4 hastalarının SWE ölçümleri, tedavi gerektirmeyen F0 ve F1 hastalarının ölçümleri ile karşılaştırıldı.
Bulgular: Tedavi gerektiren grup (F2, F3 ve F4) içindeki hız+SD ve kPa+SD değerleri, tedavi gerektirmeyen grup (F0 ve F1) içindeki değerlere göre anlamlı şekilde yüksekti (p < 0.05). Hız+SD için 1.85 kesme değerinin duyarlılık oranı %53.8, pozitif tahmin oranı %80.8, özgüllük oranı %83.3 ve negatif tahmin oranı %58.1 olarak bulundu. kPa+SD için, 10.8 kesme değeri duyarlılık oranı %51.3, pozitif tahmin oranı %95.2, özgüllük oranı %96.7 ve negatif tahmin oranı %60.4 olarak saptandı. Fibroz skoru ile kPa+SD dağılımı arasında anlamlı bir korelasyon gözlendi.
Sonuç: KDE, tedavi gerektiren hastaları (F2, F3 ve F4) tedavi gerektirmeyen hastalardan ayırt edebilir.

Keywords

Shear Wave Elastografi, karaciğer, fibrozis

The Role of Shear Wave Elastography in Predicting Early Stage Liver Fibrosis

Abstract

Aim: We examined the relationship between shear wave elastography (SWE) values and histopathological results in our study. Thus, we found the sensitivity of SWE in demonstrating early fibrosis.
Materials and Methods: A total of consecutive 70 patients with chronic hepatitis B were prospectively evaluated. The patients included in fibrosis stages (F) 0, 1, 2, 3 and 4 according to Ishak scoring were examined with SWE. SWE measurements of F2, F3 and F4 patients who were found to have early stage fibrosis were compared with those of F0 and F1 patients.
Results: The velocity+SD, and kPa+SD values in the group requiring treatment (F2, F3 and F4) were significantly higher than the group not requiring treatment (F0 and F1 )(p < 0.05). The sensitivity rate of the 1.85 cut-off value for velocity+SD was 53.8%, the positive prediction rate was 80.8%, the specificity rate was 83.3%, and the negative prediction rate was 58.1%. For kPa+SD, the cut-off value of 10.8 had a sensitivity rate of 51.3%, a positive prediction rate of 95.2%, a specificity of 96.7%, and a negative predictive rate of 60.4%. A significant correlation was observed between the fibrosis score and the kPa+SD distribution.
Conclusion: SWE can differentiate the patients requiring treatment (F2, F3 and F4) from the patients not requiring treatment.

Keywords

Sher Wave Elastgraphy, Liver, Fibrosis

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