Yeni Tanılı Çoklu Miyeloma Tanılı Hastalarda Blastocystis Hominis ve Gastrointestinal Sistem Parazitlerinin Yaygınlığı

Year 2024, , 656 - 659, 31.10.2024

Cem Selim , İrfan Yavaş , Rafiye Ciftciler , Hatice Ertabaklar , Sema Ertuğ , Ali Bolaman

https://doi.org/10.54005/geneltip.1452726

Abstract

Giriş: Multipl miyelom (MM), kemik iliğinde anormal klonal plazma hücrelerinin varlığıyla karakterize hematolojik bir malignitedir. Multipl miyelom (MM) hastalarında görülen immün yetmezlik ciddi bir sorundur. Blastocystis sp. gastrointestinal sistemde bulunur ve insanları enfekte edebilir.
Arka Plan/ Amaçlar: Çalışmamızda, B. hominis ve diğer parazitlerin yaygınlığını kontrol grubu ve yakın zamanda multipl miyelom tanısı almış hastalarla karşılaştırdık.
Materyal-Yöntemler: Çalışmamıza merkezimizden 95 multipl miyelom hastası ve kontrol grubu olarak 95 gönüllü dahil edildi. Hastaların dışkı örnekleri alındığında herhangi bir semptomu yoktu. B. hominis için, üç ardışık dışkı örneği salin-lugol trikrom boyama ve formalin-etil asetat konsantrasyonu ile incelendi. Veriler kaydedildi ve SPSS 25.0 kullanılarak analiz edildi.
Sonuçlar: Yeni tanı almış multipl miyelomlu hastalar ve kontrol grubundaki hastaların hiçbirinde B.hominis dışında parazit yoktu. Yeni tanı almış MM hastaları ile kontrol grubu arasında dışkıda B.hominis görülme sayısı açısından anlamlı fark bulundu (p <0,001).
Tartışma: Bu sonuca göre MM hastalarında dışkıdaki parazit yükü artmıştır. Bu sonuç MM hastalarının bağışıklık sisteminin baskılanmasını yansıtıyor olabilir. Buna göre MM hastalarında tedavi sırasında ortaya çıkabilecek gastrointestinal semptomların varlığında B.hominis etken olarak düşünülmelidir.

Keywords

Multipl miyelom, Parazitler, Blastocystis hominis

The Prevalence of Blastocystis Hominis and Gastrointestinal System Parasites in Patients With Newly Diagnosed Multiple Myeloma Diagnosis

Abstract

Introduction: Multiple myeloma (MM) is a hematological malignancy characterized by the presence of abnormal clonal plasma cells in the bone marrow. Immunodeficiency seen in patients with multiple myeloma (MM) is a serious problem. Blastocystis sp. is found in the gastrointestinal tract and can infect humans.
Background/ Aims: In our study, we compared the prevalence of B.hominis and other parasites with the control group and patients who had recently been diagnosed with multiple myeloma.
Material-Methods: Ninety-five multiple myeloma patients from our center and 95 volunteers as a control group were included in our study. The patients did not have any symptoms when stool samples were taken. For B.hominis, three consecutive stool samples were examined by saline-lugol trichrome staining and formalin-ethyl acetate concentration. Data were recorded and analyzed using SPSS 25.0.
Results: Patients with newly diagnosed multiple myeloma and any of the patients in the control group did not have any parasites other than B.hominis. A significant difference was found between the newly diagnosed MM patients and the control group in terms of the number of B.hominis occurrences in the stool (p <0.001).
Conclusions: According to this result, parasite load in stool increased in patients with MM. This result may reflect the suppression of the immune system of patients with MM. Accordingly, B.hominis should be considered as a causative agent in the presence of gastrointestinal symptoms that may occur during treatment in patients with MM.

Keywords

Multiple myeloma, parasites, blastocystis hominis

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