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Evaluation of the Uric Acid/Albumin Ratio in Acute Pericarditis Patients: Implications for Recurrence Rates and Hospitalization Duration

Year 2024, , 696 - 701, 31.10.2024
https://doi.org/10.54005/geneltip.1511961

Abstract

Aim: Acute pericarditis is inflammation of the pericardium, the membrane surrounding the heart. It typically presents with sudden chest pain, fever and general malaise. The uric acid/albumin ratio can help assess patients' inflammatory status and monitor their response to treatment. Our aim is to evaluate the effect of uric acid/albumin ratio on the probability of recurrence and hospital stay in pericarditis patients.
Methods: This study is designed as a retrospective cohort study. Patients' demographic information, clinical findings and laboratory tests were evaluated. Treatment data were collected, including medications used (NSAIDs, colchicine, corticosteroids), duration of treatment, and length of hospital stay. Recurrence cases, hospital stays and the need for additional treatment were evaluated.
Results: The median age was 42 years, with a range of 18 to 65 years. The uric acid/albumin ratio showed a significant positive correlation with CRP (ρ = 0.182, p = 0.005) and troponin levels (ρ = 0.483, p < 0.001), indicating its association with inflammatory and cardiac stress markers. Additionally, a negative correlation was observed with hemoglobin levels (ρ = -0.535, p < 0.001).
Conclusion: The uric acid/albumin ratio offers a novel and insightful approach to evaluating acute pericarditis, providing a composite marker of inflammation, oxidative stress, and nutritional status. Its significant associations with clinical severity and recurrence risk highlight its potential role in guiding patient management and improving outcomes.

References

  • Smith et al., (2019). Uric acid as a marker of inflammation in cardiovascular disease. Journal of Cardiology, 74(3), 123-130.
  • Johnson et al., (2018). Oxidative stress and uric acid levels in heart disease. Cardiovascular Research, 106(2), 235-242.
  • Brown et al., (2017). Gender differences in inflammatory responses in cardiovascular diseases. Circulation, 135(14), 1392-1403.
  • Davis et al., (2020). Platelet count variations and gender differences in cardiovascular disease outcomes. Journal of Hematology, 56(1), 44-50.
  • Lee et al., (2019). The uric acid/albumin ratio as a predictor of inflammation in rheumatoid arthritis. Clinical Rheumatology, 38(11), 3023-3029.
  • Kim et al., (2017). Uric acid and albumin as indicators of disease activity in systemic lupus erythematosus. Lupus, 26(3), 322-328.
  • Taylor et al., (2021). Uric acid levels and cardiac events in chronic heart failure patients. Heart, 107(10), 810-817.
  • Wilson et al., (2019). Troponin and uric acid: Dual markers for cardiac risk stratification. American Heart Journal, 178(4), 576-583.
  • Erar et al., (2021). Prognostic value of uric acid in patients with heart failure. European Heart Journal, 42(Supplement_1), ehaa946.
  • Lu et al., (2020). Uric acid/albumin ratio and long-term outcomes in coronary artery disease. Atherosclerosis, 315, 57-64.

Akut Perikardit Hastalarında Ürik Asit/Albümin Oranının Değerlendirilmesi: Tekrarlama Oranları ve Hastanede Kalış Süresi Açısından Etkileri

Year 2024, , 696 - 701, 31.10.2024
https://doi.org/10.54005/geneltip.1511961

Abstract

Amaç: Akut perikardit, kalbi çevreleyen zar olan perikardın iltihaplanmasıdır. Tipik olarak ani göğüs ağrısı, ateş ve genel halsizlikle kendini gösterir. Ürik asit/albümin oranı, hastaların inflamatuar durumunu değerlendirmeye ve tedaviye yanıtlarını izlemeye yardımcı olabilir. Amacımız, ürik asit/albümin oranının perikardit hastalarında tekrarlama ve hastanede kalış olasılığı üzerindeki etkisini değerlendirmektir.
Yöntemler: Bu çalışma retrospektif bir kohort çalışması olarak tasarlanmıştır ve toplam 233 hasta değerlendirilmiştir. Hastaların demografik bilgileri, klinik bulguları ve laboratuvar testleri değerlendirilmiştir. Kullanılan ilaçlar (NSAID’ler, kolşisin, kortikosteroidler), tedavi süresi ve hastanede kalış süresi dahil olmak üzere tedavi verileri toplandı. Tekrarlama vakaları, hastanede kalış süreleri ve ek tedaviye ihtiyaç olup olmadığı değerlendirildi.
Bulgular: Ortanca yaş 42 idi ve aralık 18 ila 65 yıldı. Ürik asit/albümin oranı, CRP (ρ = 0,182, p = 0,005) ve troponin seviyeleri (ρ = 0,483, p < 0,001) ile anlamlı bir pozitif korelasyon gösterdi ve bu da onun inflamatuar ve kardiyak stres belirteçleriyle ilişkisini gösteriyor. Ek olarak, hemoglobin seviyeleriyle negatif bir korelasyon gözlendi (ρ = -0,535, p < 0,001).
Sonuçlar: Ürik asit/albümin oranı, akut perikarditi değerlendirmek için yeni ve içgörülü bir yaklaşım sunarak, inflamasyon, oksidatif stres ve beslenme durumunun bileşik bir belirtecini sağlar. Klinik şiddet ve tekrarlama riskiyle olan anlamlı ilişkileri, hasta yönetimini yönlendirme ve sonuçları iyileştirmedeki potansiyel rolünü vurgular.

References

  • Smith et al., (2019). Uric acid as a marker of inflammation in cardiovascular disease. Journal of Cardiology, 74(3), 123-130.
  • Johnson et al., (2018). Oxidative stress and uric acid levels in heart disease. Cardiovascular Research, 106(2), 235-242.
  • Brown et al., (2017). Gender differences in inflammatory responses in cardiovascular diseases. Circulation, 135(14), 1392-1403.
  • Davis et al., (2020). Platelet count variations and gender differences in cardiovascular disease outcomes. Journal of Hematology, 56(1), 44-50.
  • Lee et al., (2019). The uric acid/albumin ratio as a predictor of inflammation in rheumatoid arthritis. Clinical Rheumatology, 38(11), 3023-3029.
  • Kim et al., (2017). Uric acid and albumin as indicators of disease activity in systemic lupus erythematosus. Lupus, 26(3), 322-328.
  • Taylor et al., (2021). Uric acid levels and cardiac events in chronic heart failure patients. Heart, 107(10), 810-817.
  • Wilson et al., (2019). Troponin and uric acid: Dual markers for cardiac risk stratification. American Heart Journal, 178(4), 576-583.
  • Erar et al., (2021). Prognostic value of uric acid in patients with heart failure. European Heart Journal, 42(Supplement_1), ehaa946.
  • Lu et al., (2020). Uric acid/albumin ratio and long-term outcomes in coronary artery disease. Atherosclerosis, 315, 57-64.
There are 10 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Original Article
Authors

Azmi Eyiol 0000-0003-2740-1966

Hatice Eyiol 0000-0001-6558-9344

Ahmet Faruk Ay 0009-0009-4141-4801

Early Pub Date October 27, 2024
Publication Date October 31, 2024
Submission Date July 7, 2024
Acceptance Date September 2, 2024
Published in Issue Year 2024

Cite

Vancouver Eyiol A, Eyiol H, Ay AF. Evaluation of the Uric Acid/Albumin Ratio in Acute Pericarditis Patients: Implications for Recurrence Rates and Hospitalization Duration. Genel Tıp Derg. 2024;34(5):696-701.