Stabil Koroner Arter Hastalığı Olan Şizofreni Hastalarında Monosit/Yüksek Yoğunluklu Lipoprotein (MHR) Oranının Öngördürücülüğü

Year 2022, Volume: 32 Issue: 1, 77 - 83, 28.02.2022

Mustafa Candemir , Alparslan Cansız

https://doi.org/10.54005/geneltip.1032165

Cited By: 1

Abstract

Amaç: Bu çalışmada stabil koroner arter hastalığı olan şizofreni hastalarında (SKAH-Ş) monosit/yüksek yoğunluklu lipoprotein oranının (MHO) tanıda öngördürücü değerinin olup olmadığını araştırmayı amaçladık.
Gereç ve yöntem: Bu kesitsel çalışmaya toplam 281 katılımcı alındı. Katılımcıların 85'ine şizofreni ve stabil koroner arter hastalığı (Grup 1), 92'sine ise sadece şizofreni (Grup 2) tanısı konuldu. Kontrol grubundaki 104 katılımcının (Grup 3) ise hiçbir hastalığı yoktu.
Bulgular: MHO grup 1'de en yüksek iken grup 2'de grup 3'e göre daha yüksekti (grup 1: 18.91 (13.38-23.60); grup 2: 13.68 (11.11-16.66); grup 3: 12.50 (9.13-15.68); her iki karşılaştırma için p <0.001). Buna zıt olarak, HDL grup 1'de en düşük iken grup 2'de grup 3'e göre daha düşüktü (grup 1: 38.52 ± 9.45; grup 2: 42.76 ± 9.12; grup 3: 47.00 ± 11.87; her iki karşılaştırma için p <0.05). MHO'nun kesme puanı stabil koroner arter hastalığı olan şizofreni hastalarında 12.77 ve üzeri alındığında duyarlılık %79, özgüllük ise %43 bulundu. Sadece şizofreni hastalarında ise kesme değeri 10.73 ve üzeri alındığında duyarlılık % 79, özgüllük ise % 50 bulundu.
Sonuç: Artmış inflamasyon ve oksidatif stresi gösteren yüksek MHO, şizofreni ve stabil koroner arter hastalığı olan şizofreni hastalarında önemli ve bağımsız bir belirteç olarak bulundu.

Keywords

Koroner arter hastalığı, şizofreni, monosit/yüksek yoğunluklu lipoprotein oranı, inflamasyon, oksidatif stres

Supporting Institution

yok

Project Number

yok

Predictive Value of Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR) in Schizophrenia Patients with Stable Coronary Artery Disease

Abstract

Aim: We aimed to investigate whether monocyte/high density lipoprotein ratio (MHR) has a predictive value in patients with schizophrenia (SP) and in schizophrenia patients with stable coronary artery disease (SPCAD).
Material and Method: A total of 281 participants were enrolled in this cross-sectional study. Of the participants, 85 (Group 1) were diagnosed schizophrenia and stable coronary artery disease, and 92 (Group 2) were diagnosed only schizophrenia. 104 (Group 3) participants in the control group had no disease.
Results: MHR was highest in group 1 and higher in group 2 than in group 3 (18.91 (13.38-23.60) vs. 13.68 (11.11-16.66) vs. 12.50 (9.13-15.68), respectively; p<0.001 for both). Conversely, HDL was the lowest in group 1, while it was lower in group 2 than in group 3 (38.52 ± 9.45 vs. 42.76 ± 9.12 vs. 47.00 ± 11.87, respectively p<0.05 for both). The cutoff value of MHR for SPCAD was 12.77, with a sensitivity of 79% and a specificity of 43%. This value for SP was 10.73, with a sensitivity of 79% and a specificity of 50%.
Conclusion: High MHR which indicates an enhanced inflammation and oxidative stress was found to be a significant and independent marker in SP and SPCAD.

Keywords

schizophrenia, Coronary artery disease, monocyte to high-density lipoprotein ratio, inflammation, oxidative stress

Project Number

yok

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