The Relationship Between Vitamin D Levels and Severity of Menopausal Symptoms

Year 2022, Volume: 32 Issue: 5, 559 - 563, 29.10.2022

Anıl Erturk , Nergis Kender Erturk

https://doi.org/10.54005/geneltip.1148944

Abstract

Introduction: Our aim was to investigate the relationship between menopausal symptoms and serum vitamin D levels.
Methods: We analyzed 110 postmenopausal women aged between 42-65 years among menopause symptoms by using Menopause Rating Scale (MRS) questionnaire. Patients were divided into three groups according to their serum 25-OH vitamin D levels; sufficient (>20 ng/mL), insufficient (12-20 ng/mL), deficient (<12 ng/mL), then compared. Serum vitamin D cut-off level was determined for menopausal symptoms. The correlations between symptoms and vitamin D status were calculated.
Results: Vitamin D deficiency was detected in 38,1% (42/110) of the participants. The total MRS score was 22,97±2,71 in Vitamin D deficiency group and significantly higher than others (p<0,001). In deficiency group, somatic, psyhcological and urogenital subscale scores were higher than other groups (p<0,001, p=0,007 and p=0,036, respectively). Evaluation of the correlations among independent variables revealed a negative relationship between vitamin D level and MRS scores. The threshold value at which serum vitamin D causes severe MRS scores in those with sufficient levels was calculated as 25.31 ng/ml. The area under the ROC curve was 0,876 (95% CI, 0,702-1,00, p=0.003).
Conclusion: In the present study, a relationship between serum vitamin D levels and menopause-related symptoms in postmenopausal population was demonstrated. Low levels of vitamin D in menopausal period might aggravate menopause-related symptoms.

Keywords

Menopause-related symptoms, vitamin D, postmenopausal

Vitamin D ve menopozal semptomların şiddeti arasındaki ilişki

Abstract

Amaç: Amacımız menopoz semptomları ile serum D vitamini düzeyleri arasındaki ilişkiyi araştırmaktı.
Gereç-Yöntem: Menopoz semptomları, 42-65 yaş arası 110 postmenopozal kadında Menopoz Derecelendirme Ölçeği (MDÖ) anketi kullanılarak analiz edildi. Hastalar serum 25-OH D vitamini düzeylerine göre üç gruba ayrıldı; yeterli (>20 ng/mL), azalmış (12-20 ng/mL), eksik (<12 ng/mL), sonra karşılaştırıldı. Şiddetli menopoz semptomlarına yol açan serum D vitamini düzeyi için ROC eğirisi ile eşik değer belirlendi. Semptomlar ve vitamin D seviyesi arasındaki korelasyon hesaplandı.
Bulgular: Katılımcıların %38,1'inde (42/110) D vitamini eksikliği saptandı. D vitamini eksikliği grubunda toplam MDÖ puanı 22,97±2,71 olup diğerlerinden anlamlı olarak yüksekti (p<0,001). Eksiklik grubunda somatik, psikolojik ve ürogenital alt ölçek puanları diğer gruplara göre daha yüksekti (sırasıyla p<0,001, p=0,007 ve p=0,036). Bağımsız değişkenler arasındaki korelasyonlar değerlendirildiğinde, D vitamini düzeyi ile MDÖ puanları arasında negatif bir ilişki ortaya çıktı. Yeterli düzeyde olanlarda serum D vitamininin ciddi MDÖ skorlarına neden olduğu eşik değer 25.31 ng/ml olarak hesaplandı. ROC eğrisi altında kalan alan 0,876 (%95 CI, 0,702-1,00, p=0,003) idi.
Sonuç: Bu çalışmada postmenopozal popülasyonda serum D vitamini düzeyleri ile menopoza bağlı semptomlar arasında ilişki olduğu gösterilmiştir. Menopoz dönemindeki düşük D vitamini seviyeleri menopoza bağlı semptomları şiddetlendirebilir.

Keywords

menopozal semptomlar, vitamin d, postmenopoz

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