Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?

Year 2023, Volume: 33 Issue: 4, 384 - 389, 31.08.2023

Hakan Ozer , Kader Zeybek Aydoğan , Yasin Öztürk , Fethi Yönet , İsmail Baloğlu

https://doi.org/10.54005/geneltip.1206894

Abstract

Background and Aim: Diabetic nephropathy is the most common cause of end-stage renal disease and albuminuria is the earliest manifestation of diabetic nephropathy.Oxidative stress and inflammation caused by advanced glyco-oxidation end products contribute to micro and macrovascular complications of diabetes. Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) is an essential indicator of inflammation and oxidative stress. In this study, we aimed to reveal the relationship between diabetes regulation and complications and MHR.
Material and Method: A total of 182 subjects, including 152 patients with diabetes mellitus (DM) and 30 healthy controls, were included in this study. All data of the subjects were scanned retrospectively. The DM group was divided into two groups nephropathy (n=68) and non-nephropathy (n=84), with a limit of 30 mg/day for albuminuria. MHR was calculated by dividing the monocyte count by the HDL cholesterol count.
Results: When patients with DM were divided into nephropathy and non-nephropathy, patients with nephropathy had higher MHR levels than the other group. We showed that MHR correlated with albuminuria, creatinine, and HbA1c in patients with diabetic nephropathy. In addition, in the regression analysis, albuminuria and MHR were predictors of DN, while MHR, age, and creatinine were found to be independent predictors of albuminuria.
Conclusion: MHR, which is an easily calculated marker with simple laboratory tests, which is frequently requested in routine practice in the follow-up of diabetes patients, can help predict the regulation of diabetes and its kidney complications.

Keywords

Albuminuria, diabetic nephropathy, inflammation, monocyte-hdl cholesterol ratio, Albüminüri, diyabetik nefropati, inflamasyon, monosit-HDL kolesterol oranı

Monosit-HDL Oranı: Diyabetik Hastaların Takibinde ve Diyabetik Nefropatinin Tanısında Kullanılabilir mi ?

Abstract

Giriş ve Amaç: Diyabetik nefropati, son dönem böbrek hastalığının en yaygın nedenidir ve albüminüri, diyabetik nefropatinin en erken belirtisidir. İleri gliko-oksidasyon son ürünlerinin neden olduğu oksidatif stres ve inflamasyon, diyabetin mikro ve makrovasküler komplikasyonlarına katkıda bulunur. Monosit sayısının, yüksek yoğunluklu lipoprotein (HDL) kolesterol seviyesine oranı (MHR), inflamasyon ve oksidatif stresin önemli bir göstergesidir. Çalışmada, diyabet regülasyonu ve komplikasyonlarıyla MHR arasındaki ilişkinin ortaya çıkarılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmaya 152’si diabetes mellitus (DM) hastası ve 30’u sağlıklı kontrol olmak üzere toplam 182 kişi dahil edildi. Olguların tüm verileri retrospektif olarak tarandı. DM grubu albüminüri sınırı 30 mg/gün olmak üzere, nefropatisi olan (n=68) ve non-nefropatili (n=84) olmak üzere iki gruba ayrıldı. MHR, monosit sayısının HDL kolesterol sayısına bölünmesiyle hesaplandı.
Bulgular: DM'li hastalar nefropatik ve non-nefropatik olarak ayrıldığında, nefropatili hastaların MHR düzeyleri diğer gruba göre daha yüksekti. Diyabetik nefropatili hastalarda MHR'nin albüminüri, kreatinin ve HbA1c ile korele olduğunu gösterdik. Ayrıca regresyon analizinde albüminüri ve MHR DN'yi öngördürürken, MHR, yaş ve kreatinin düzeyi albüminürinin bağımsız ön görüdürücüleriydi.
Sonuç: Diyabet hastalarının takibinde rutin pratikte sıklıkla istenen ve basit laboratuvar testleri ile kolayca hesaplanabilen bir belirteç olan MHR, diyabetin hem regülasyonunda hem de böbrek komplikasyonlarını öngörmede faydalı bir belirteç olabilir.

Keywords

Albüminüri, diyabetik nefropati, inflamasyon, monosit-HDL kolesterol oranı

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