İntrakaviter Serviks Brakiterapisi için Ters Planlama Simüle Tavlama ve Manuel Optimizasyonun Dozimetrik Karşılaştırması

Year 2024, Volume: 34 Issue: 1, 109 - 113, 29.02.2024

Osman Vefa Gül , Hamit Başaran , Mursel Duzova , Gökçen İnan

https://doi.org/10.54005/geneltip.1375470

Abstract

Arkaplan/Hedefler: Brakiterapi tedavi planlamasında farklı optimizasyon yöntemleri kullanılmaktadır. Bu çalışmanın amacı, serviks kanserinin brakiterapisinde yaygın olarak kullanılan manuel optimizasyon (MO) ve ters planlama simüle edilmiş tavlama (IPSA) planlama teknikleri arasındaki dozimetrik farklılıkları değerlendirmektir.
Yöntemler: Bu çalışmaya on beş serviks kanseri hasta dahil edildi. Tedavide Nucletron standart tandem-ovoid (TO) aplikatörler kullanıldı. Yüksek riskli klinik tümör hacmi (HR-CTV), mesane, rektum ve sigmoid şekillendirme GEC-ESTRO tavsiyelerine göre yapıldı. IPSA ve MO teknikleri kullanılarak her hasta için iki plan oluşturuldu. Planlama aşamasında hedef hacme 700 cGy doz reçete edilirken, risk altındaki organların en iyi şekilde korunmasına çalışıldı. IPSA ve MO planlama teknikleri doz hacim histogramı (DVH) aracılığıyla karşılaştırıldı.
Bulgular: MO ve IPSA teknikleri için HR-CTV ve CI değerleri arasında anlamlı fark yoktu. Rektumun 2cm3 hacmi açısından IPSA ve MO teknikleri arasında anlamlı fark vardı (p= 0.002). IPSA tekniği ile mesanenin daha iyi korunduğu görüldü. Mesane için IPSA ve MO arasında %6,26 doz farkı vardı. Sigmoidin 2cm3 hacmi açısından IPSA ve MO teknikleri arasında anlamlı fark bulundu (p= 0.002). IPSA tekniği zaman açısından MO tekniğinden üstündü.
Sonuç: IPSA tekniği risk altındaki organların (OARs) korunması açısından MO tekniğinden üstündü. IPSA, serviks brakiterapisinde daha hızlı ve kaliteli bir plan sağlar.

Keywords

Brakiterapi, Serviks kanseri, IPSA

Project Number

22301001

Dosimetric Comparison of Inverse Planning Simulated Annealing and Manual Optimization for Intracavitary Cervix Brachytherapy

Abstract

Background/Aims: Different optimization methods in brachytherapy treatment planning is used. The aim of this study is to evaluate dosimetric differences between manual optimization (MO) and inverse planning simulated annealing (IPSA) planning techniques commonly used in brachytherapy of cervical cancer.
Methods: Fifteen cervical cancer patients were included in this study. Nucletron standard tandem-ovoid (TO) applicators were used for treatment. High-risk clinical tumor volume (HR-CTV), bladder, rectum, and sigmoid contouring were performed according to GEC-ESTRO recommendations. Two plans were created for each patient using IPSA and MO techniques. While a dose of 700 cGy was prescribed to the target volume during the planning phase, an effort was made to protect the organs at risk in the best way possible. IPSA and MO planning techniques were compared via dose volume histogram (DVH).
Results: There was no significant difference between HR-CTV and CI values for MO and IPSA techniques. There was a significant difference between IPSA and MO techniques for the 2cm3 volume of the rectum (p= 0.002). It was observed that the bladder was better protected by the IPSA technique. There was a 6.26% dose difference between IPSA and MO for the bladder. A significant difference was found between IPSA and MO techniques for the 2cm3 volume of the sigmoid (p= 0.002). The IPSA technique was superior to the MO technique in terms of time.
Conclusions: The IPSA technique was superior to the MO technique in terms of protecting organs at risk (OARs). IPSA provides a faster and higher quality plan in cervical brachytherapy.

Keywords

Brachytherapy, Cervix cancer, IPSA

Supporting Institution

This study was supported by the Scientific Research Projects (BAP) Grants Unit, Selcuk University, Konya, TURKEY

Project Number

22301001

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