The Role of Chronic Psychological Stress in the Pathogenesis of Osteoporosis: Associated Mechanisms and Potential Biomarkers

Year 2023, , 40 - 51, 30.04.2023

Cihan Akdoğan , Funda Bayındır

https://doi.org/10.47141/geriatrik.1147586

Abstract

Osteoporosis is an age-related bone disease characterized by reduced bone mass and destruction of bone microarchitecture, leading to fracture risk. Organisms are constantly exposed to various stressful stimuli that affect physiological processes. At the present time, it has been shown that physical stress affects the bone structure by stimulates the bone remodeling. It is reported in the literature that chronic psychological stress as well as physical stress is a risk factor for osteoporosis by various signaling pathways. Both animal and human studies show that chronic psychological stress causes reduction in bone mass and deterioration in bone quality by affecting various pathways, including the hypothalamic-pituitary-adrenocortical (HPA) axis, sympathetic nervous system, and other endocrine factors. This review discusses for psychological stress as risk factor for osteoporosis, associated mechanisms and potential biomarkers.

Keywords

biomarker, osteoporosis, physiological stress

Kronik Psikolojik Stresin Osteoporoz Patogenezindeki Rolü: İlişkili Mekanizmalar ve Potansiyal Biyobelirteçler

Abstract

Osteoporoz, azalmış kemik kütlesi ve kemik mikromimarisinin yıkımı ile karakterize kırık riskine neden olan yaşa bağlı bir kemik hastalığıdır. Organizmalar sürekli olarak fizyolojik süreçleri etkileyen çeşitli stresli uyaranlara maruz kalırlar. Günümüzde, fiziksel stresin kemik remodelingini uyararak kemik yapısını etkilediği gösterilmiştir. Literatürde, fiziksel stresin yanı sıra kronik psikolojik stresin de çeşitli sinyal yollarıyla osteoporoz için bir risk faktörü olduğu bildirilmektedir. Hem hayvan hem de insan çalışmaları, kronik psikolojik stresin hipotalamik-hipofiz-adrenokortikal (HPA) ekseni, sempatik sinir sistemi ve diğer endokrin faktörleri dahil olmak üzere çeşitli yolları etkileyerek kemik kütlesinde azalmaya ve kemik kalitesinde bozulmaya neden olduğunu göstermektedir. Bu derlemede, osteoporoz için risk faktörü olarak kronik psikolojik stres, ilişkili mekanizmalar ve potansiyal biyobelirteçler tartışılmaktadır.

Keywords

biyobelirteç, osteoporoz, psikolojik stres

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