Exercise as a Protective and Therapeutic Intervention in Alzheimer's Disease

Year 2022, , 90 - 96, 31.12.2022

İdil Alpat , Gülgün Ersoy

https://doi.org/10.47141/geriatrik.1169599

Cited By: 1

Abstract

Alzheimer's disease; is the most common type of dementia in our country and the world, manifested by cognitive and motor disorders with insidious onset and progressive character. Epidemiological data support an inverse relationship between exercise and the risk of developing this disease. Beyond this preventive role, exercise can also slow the progression of the disease. In particular, aerobic exercise activates the release of neurotrophic factors, which in turn improves memory and cognitive functions. Exercise intervention applied as a treatment method for Alzheimer's disease; results in an improvement in cognitive function, a reduction in neuropsychiatric symptoms, and a slower decline in activities of daily living. Alzheimer's disease is common in aging populations, so even a small impact from non-pharmacological interventions such as exercise can significantly impact public health. In this review, the effect of exercise intervention in preventing and treating Alzheimer's disease is discussed.

Keywords

Alzheimer's disease, exercise, neurodegeneration, dementia

Alzheimer Hastalığında Koruyucu ve Tedavi Edici Bir Müdahale Olarak Egzersiz

Abstract

Alzheimer hastalığı; bilişsel ve motor bozukluklar ile kendini gösteren, sinsi başlangıçlı, ilerleyici vasıflı, ülkemizde ve dünyada en sık görülen demans türüdür. Epidemiyolojik veriler, egzersiz ile bu hastalığın gelişme riski arasında ters bir ilişki olduğunu desteklemektedir. Bu önleyici rolün ötesinde, egzersiz hastalığın ilerlemesini de yavaşlatabilir. Özellikle aerobik egzersiz, nörotrofik faktörlerin salınımını aktive ederek sırasıyla hafıza ve bilişsel işlevleri geliştirir. Alzheimer hastalığında tedavi yöntemi olarak uygulanan egzersiz müdahalesi; bilişsel işlevde iyileşme, nöropsikiyatrik semptomlarda azalma ve günlük yaşam aktivitelerinde daha yavaş bir etkilenim ile sonuçlanmaktadır. Alzheimer hastalığı yaşlanan toplumlarda yaygın olarak görülmekte, bu nedenle egzersiz gibi farmakolojik olmayan müdahalelerin yarattığı küçük bir etki bile halk sağlığı üzerinde büyük bir etkiye sahip olabilmektedir. Bu derlemede, Alzheimer hastalığının önlenmesi ve tedavisinde egzersiz müdahalesinin etkisi tartışılmaktadır.

Keywords

Alzheimer hastalığı, egzersiz, nörodejenerasyon, demans

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