COVID-19 Pandemisinde Geriatrik Rehabilitasyon
Year 2024,
, 51 - 67, 30.04.2024
Aynur Cin
,
Sevilay Hintistan
Abstract
Organlarda/sistemlerde meydana gelen fizyolojik değişiklikler ve fonksiyonlarda azalma, rezerv kapasitelerinde düşme, bazı patolojik durumlar ve hastalıklardan oluşan süreğen bir durum olarak tanımlanan yaşlanma doğal bir süreç olup geriatrik rehabilitasyon gerektirmektedir. Dünyayı ele geçiren COVID-19 pandemisi en çok yaşlıları olumsuz etkilemiştir. Pandemi nedeni ile geriatrik popülasyona yeterince ulaşılamamış ve rehabilitasyon programları istenilen düzeyde gerçekleştirilememiştir. Yaşlılar; pandemi döneminde pulmoner, kardiyak, psikolojik pek çok sorunla birlikte malnütrisyon, sarkopeni, ev kazaları, koruyucu sağlık hizmetlerine erişememe gibi rehabilitasyon gerektiren farklı sorunlarla karşılaşmışlardır. Bu nedenle dünya genelinde geriatrik rehabilitasyon COVID-19 pandemisinde büyük önem kazanmıştır. Bu makalede, geriatrik popülasyona yönelik sorunlara ilişkin geriatrik rehabilitasyon kapsamlı bir şekilde ele alınmıştır.
Ethical Statement
Bu çalışma bir derleme makalesi olduğundan etik kurul onayı gerekmemiştir ve bu çalışmanın yürütülmesinde Helsinki Bildirgesi kurallarına uyulmuştur.
Supporting Institution
Çalışmamızı destekleyen herhangi bir kurum bulunmamaktadır.
Thanks
Akademik ve insani desteğinden dolayı danışman Hocam Prof. Dr. Sevilay HİNTİSTAN'a teşekkür ederim.
References
- Özgüç S, Kaplan Serin E, Tanriverdi D. Death anxiety associated with coronavirus (COVID-19) disease: A systematic review and meta-analysis. Omega(Westport). 2024; 88(3):824.
- Klanidhi KB, Bhavesh M, Ranjan P, et al. Health care of the elderly during Covid-19 pandemic-All a family physician should know. J Family Med Prim Care. 2021;10(3):1077.
- Central for Diseases Control and Prevention. Risk for COVID-19 Infection, Hospitalization, and Death By Age Group (2022). https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-discovery/hospitalization-death-by-age.html. Erişim tarihi: 18.09.2023.
- Zhu W, Xie K, Lu H, et al. Initial clinical features of suspected coronavirus disease 2019 in two emergency departments outside of Hubei, China. J Med Virol. 2020;92(9):1525-1532.
- Rees EM, Nightingale ES, Jafari Y, et al. COVID-19 length of hospital stay: a systematic review and data synthesis. BMC Med. 2020;18(1):270.
- Arentz M, Yim E, Klaff L, et al. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State. JAMA. 2020;323(16): 1612-1614.
- Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020;34:101623.
- Defi IR, Nirmala E, Thaharoh YA. Geriatric rehabilitation during COVID-19: a lesson learned. Journal of Gerontology and Geriatrics. 2022;70:59-65.
- De Biase S, Cook L, Skelton DA, et al. The COVID-19 rehabilitation pandemic. Age and ageing. 2020;49(5): 697.
- Liu K, Chen Y, Lin R, et al. Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. J Infect. 2020;80(6):e14-e18.
- Wang L, He W, Yu X, et al. Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. J Infect. 2020;80(6):639-645.
- Werner C, Scullen T, Mathkour M, et al. Neurological Impact of Coronavirus Disease of 2019: Practical Considerations for the Neuroscience Community. World Neurosurg. 2020;139:344-354.
- Huang C, Soleimani J, Herasevich S, et al. Clinical Characteristics, Treatment, and Outcomes of Critically Ill Patients With COVID-19: A Scoping Review. Mayo Clin Proc. 2021;96(1):183-202.
- Grund S, Gordon AL, van Balen R, et al. European consensus on core principles and future priorities for geriatric rehabilitation: consensus statement. Eur Geriatr Med. 2020;11(2):233-238.
- Xu H, Huang S, Qiu C, et al. Monitoring and Management of Home-Quarantined Patients With COVID-19 Using a WeChat-Based Telemedicine System: Retrospective Cohort Study. J Med Internet Res. 2020;22(7): e19514.
- Ye Z, Zhang Y, Wang Y, et al. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol. 2020;30(8):4381-4389.
- Kurtaiş Aytür Y, Köseoğlu BF, Özyemişçi Taşkıran Ö, et al. Pulmonary rehabilitation principles in sARs-COV-2 infection (COVID-19): the revised guideline for the acute, subacute, and post-COVID-19 rehabilitation. Turk J Phys Med Rehabil. 2021;67(2):129-45.
- Pan Y, Guan H, Zhou S, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China. Eur Radiol. 2020;30(6):3306-3309.
- Calabrese M, Garofano M, Palumbo R, et al. Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art. Life (Basel). 2021;11(3):259. Published 2021 Mar 21.
- Zhu C, Wu Y, Liu H, et al. Early pulmonary rehabilitation for SARS-CoV-2 pneumonia: Experience from an intensive care unit outside of the Hubei province in China. Heart Lung. 2020;49(5):449-450.
- Alhazzani W, Møller MH, Arabi YM, et al. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med. 2020;46(5):854-887.
- Yang LL, Yang T. Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19). Chronic Dis Transl Med.2020;6(2):79-86.
- Shah W, Hillman T, Playford ED, et al. Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline. BMJ. 2021;372:136.
- HAS. Rapid responses in the context of COVID-19-Management of post-COVID-19 patients in Physical Medicine and Rehabilitation units (MPR), in Follow-on Care and Rehabilitation units (SSR) and on return home. https://www.has-sante.fr/jcms/p_3179826/en/management-of-covid-patients-in-physical-medicine-and-rehabilitation-mpr-and-on-return-home. 16 April 2020’de basıldı. Erişim Tarihi:10.04.2022.
- Greenhalgh T, Knight M, A’Court C, et al. Management of post-acute covid-19 in primary care. BMJ. 2020; 370: m3026.
- 26.Inoue S, Hatakeyama J, Kondo Y, et al. Post-intensive care syndrome: its pathophysiology, prevention, and future directions. Acute Med Surg. 2019;6(3):233-246.
- Sheehy LM. Considerations for Postacute Rehabilitation for Survivors of COVID-19. JMIR Public Health Surveill. 2020;6(2):e19462.
- Solomen S, Aaron P. Breathing techniques-a review-25 different types breathing techniques-A review. International Journal of Physical Education, Sports and Health 2015;2(2):237-241.
- Muchiri WA, Olutende OM, Kweyu IW, et al. Meaning of Physical Activities for the Elderly: A Review. Am J Sports Sci Med. 2018;6:79-83.
- Lee PG, Jackson EA, Richardson CR. Exercise Prescriptions in Older Adults. Am Fam Physician. 2017; 95(7):425-432.
- Soygüden A, Cerit E. Yaşlılar İçin Egzersiz Uygulamalarının Önemi. Hitit Üniversitesi Sosyal Bilimler Enstitüsü Dergisi. 2015;8(1):197-224.
- Department of Health Australian Government. Recommendations on physical activity for health for older Australians. https://www1.health.gov.au/internet/main/publishing.nsf/Content/phd-physical-rec-older-guidelines. Published:07.05.2021. Erişim Tarihi: 06.04.2022.
- World Health Organization Guideline. Global Recommendations and Physical Activity for Health. Age Group 65 Years Old and Above. https://iris.who.int/bitstream/handle/10665/44399/9789241599979_eng.pdf?sequence=1 Published:2010. Erişim Tarihi:18.01.2024.
- Bao R, Chen ST, Wang Y, et al. Sedentary Behavior Research in the Chinese Population: A Systematic Scoping Review. Int J Environ Res Public Health. 2020;17(10):3576. Published 2020 May 20.
- Jiménez-Pavón D, Carbonell-Baeza A, Lavie CJ. Physical exercise as therapy to fight against the mental and physical consequences of COVID-19 quarantine: Special focus in older people. Prog Cardiovasc Dis. 2020;63(3):386-388.
- Salar S, Akel S. Covid-19 ve Ergoterapi: Salgın Hastalıklara Hızlı Cevap Verme ve Hazırlıklı Olma Boyutuyla Bir Gözden Geçirme Çalışması. Ergoterapi ve Rehabilitasyon Dergisi. 2020;8(2):161-174.
- Ceravolo MG, de Sire A, Andrenelli E, et al. Systematic rapid “living” review on rehabilitation needs due to COVID-19: update to March 31st, 2020. Eur J Phys Rehabil Med. 2020;56(3):347-353.
- Bostrom J, Sweeney G, Whiteson J, et al. Mobile health and cardiac rehabilitation in older adults. Clin Cardiol. 2020;43(2):118-126.
- Schumacher S, Kent N. Eight charts on internet use around the world as countries grapple with COVID-19. Pew Research Center. https://www.pewresearch.org/fact-tank/2020/04/02/8-charts-on-internet-use-around-the-world-as-countries-grapple-with-covid-19/ Published:02.04.2020 Erişim Tarihi:11.10.2023.
- Feng Z, Lugtenberg M, Franse C, et al. Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: A systematic review of longitudinal studies. PLoS One. 2017;12(6):e0178383.
- Hewitt J, Carter B, Vilches-Moraga A, et al. The effect of frailty on survival in patients with COVID-19 (COPE): A multicentre, European, observational cohort study. Lancet Public Health. 2020;5(8):e444-e451.
- Steinman MA, Perry L, Perissinotto CM. Meeting the Care Needs of Older Adults Isolated at Home During the COVID-19 Pandemic. JAMA Intern Med. 2020;180(6):819-820.
- Gropper S, Hunt D, Chapa DW. Sarcopenia and Psychosocial Variables in Patients in Intensive Care Units: The Role of Nutrition and Rehabilitation in Prevention and Treatment. Crit Care Nurs Clin North Am. 2019;31(4):489-499.
- Volkert D, Beck AM, Cederholm T, et al. Management of Malnutrition in Older Patients-Current Approaches, Evidence and Open Questions. J Clin Med. 2019;8(7):974.
- Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772.
- Cheng HM, Koutsidis G, Lodge JK, et al. Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence. Crit Rev Food Sci Nutr. 2019;59(1):141-158.
- Muir SW, Montero-Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: A systematic review and meta-analysis. J Am Geriatr Soc. 2011;59(12):2291-2300.
- Azzolino D, Damanti S, Bertagnoli L, et al. Sarcopenia and swallowing disorders in older people. Aging Clin Exp Res. 2019;31(6):799-805.
- Szanton S, Leff B, Wolff J, et al. Home-Based Care Program Reduces Disability and Promotes Aging In Place. Health Aff (Millwood). 2016;35(9):1558-1563.
- Said CM, Batchelor F, Duque G. Physical Activity and Exercise for Older People During and After the Coronavirus Disease 2019 Pandemic: A Path to Recovery. J Am Med Dir Assoc. 2020;21(7):977-979.
- Karadakovan A. Yaşlı Sağlığı ve Bakım. 1. Baskı. Ankara, Akademisyen Tıp Kitabevi, 2014, 340-359.
- Akarsu R, Bumin G. Ergoterapi Alanında Telerehabilitasyon Uygulamalarının Etkinliği. Türkiye Klinikleri Sağlık Bilimleri Dergisi. 2021;6(3):682-694.
- Hayes D. Telerehabilitation for Older Adults, Topics in Geriatric Rehabilitation. 2020;36(4):205-211.
- Cerqueira-Silva T, Oliveira VA, Boaventura VS, et al. Influence of age on the effectiveness and duration of protection of Vaxzevria and CoronaVac vaccines: A population-based study. The Lancet Regional Health-Americas. 2022;6:100154.
- Cohen SA, Kellogg C, Equils O. Neutralizing and cross-reacting antibodies: implications for immunotherapy and SARS-CoV-2 vaccine development. Human vaccines & immunotherapeutics, 2021;17(1), 84-87.
- Collier DA, Ferreira IATM, Kotagiri P, et al. Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature. 2021;596(7872):417-422.
- Mazagatos C, Monge S, Olmedo C, et al. Effectiveness of mRNA COVID-19 vaccines in preventing SARS-CoV-2 infections and COVID-19 hospitalisations and deaths in elderly long-term care facility residents, Spain, weeks 53 2020 to 13 2021. Euro Surveill. 2021;26(24):2100452.
Geriatric Rehabilitation in the COVID-19 Pandemic
Year 2024,
, 51 - 67, 30.04.2024
Aynur Cin
,
Sevilay Hintistan
Abstract
Aging, defined as a chronic condition characterized by physiological changes and a decrease in functions in organs/systems, a decrease in reserve capacities, and the occurrence of certain pathological conditions and diseases, is a natural process that necessitates geriatric rehabilitation. The COVID-19 pandemic, which has taken over the world, has had the most adverse effects on the elderly. Due to the pandemic, it has been difficult to reach the geriatric population, and rehabilitation programs have not been carried out to the desired extent. During the pandemic, the elderly have faced various issues requiring rehabilitation, including pulmonary, cardiac, and psychological problems, as well as malnutrition, sarcopenia, home accidents, and difficulties accessing preventive health services. Therefore, geriatric rehabilitation has gained significant importance globally during the COVID-19 pandemic. This article comprehensively addresses the issues related to geriatric rehabilitation for the geriatric population.
Ethical Statement
Since this study is a review article, ethics committee approval was not required and the rules of the Declaration of Helsinki were followed in conducting this study.
Supporting Institution
There are no institutions that support our work.
Thanks
Because of her academic and humanitarian support, thanks to my consultant Prof. Dr. Sevilay HİNTİSTAN.
References
- Özgüç S, Kaplan Serin E, Tanriverdi D. Death anxiety associated with coronavirus (COVID-19) disease: A systematic review and meta-analysis. Omega(Westport). 2024; 88(3):824.
- Klanidhi KB, Bhavesh M, Ranjan P, et al. Health care of the elderly during Covid-19 pandemic-All a family physician should know. J Family Med Prim Care. 2021;10(3):1077.
- Central for Diseases Control and Prevention. Risk for COVID-19 Infection, Hospitalization, and Death By Age Group (2022). https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-discovery/hospitalization-death-by-age.html. Erişim tarihi: 18.09.2023.
- Zhu W, Xie K, Lu H, et al. Initial clinical features of suspected coronavirus disease 2019 in two emergency departments outside of Hubei, China. J Med Virol. 2020;92(9):1525-1532.
- Rees EM, Nightingale ES, Jafari Y, et al. COVID-19 length of hospital stay: a systematic review and data synthesis. BMC Med. 2020;18(1):270.
- Arentz M, Yim E, Klaff L, et al. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State. JAMA. 2020;323(16): 1612-1614.
- Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020;34:101623.
- Defi IR, Nirmala E, Thaharoh YA. Geriatric rehabilitation during COVID-19: a lesson learned. Journal of Gerontology and Geriatrics. 2022;70:59-65.
- De Biase S, Cook L, Skelton DA, et al. The COVID-19 rehabilitation pandemic. Age and ageing. 2020;49(5): 697.
- Liu K, Chen Y, Lin R, et al. Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. J Infect. 2020;80(6):e14-e18.
- Wang L, He W, Yu X, et al. Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. J Infect. 2020;80(6):639-645.
- Werner C, Scullen T, Mathkour M, et al. Neurological Impact of Coronavirus Disease of 2019: Practical Considerations for the Neuroscience Community. World Neurosurg. 2020;139:344-354.
- Huang C, Soleimani J, Herasevich S, et al. Clinical Characteristics, Treatment, and Outcomes of Critically Ill Patients With COVID-19: A Scoping Review. Mayo Clin Proc. 2021;96(1):183-202.
- Grund S, Gordon AL, van Balen R, et al. European consensus on core principles and future priorities for geriatric rehabilitation: consensus statement. Eur Geriatr Med. 2020;11(2):233-238.
- Xu H, Huang S, Qiu C, et al. Monitoring and Management of Home-Quarantined Patients With COVID-19 Using a WeChat-Based Telemedicine System: Retrospective Cohort Study. J Med Internet Res. 2020;22(7): e19514.
- Ye Z, Zhang Y, Wang Y, et al. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol. 2020;30(8):4381-4389.
- Kurtaiş Aytür Y, Köseoğlu BF, Özyemişçi Taşkıran Ö, et al. Pulmonary rehabilitation principles in sARs-COV-2 infection (COVID-19): the revised guideline for the acute, subacute, and post-COVID-19 rehabilitation. Turk J Phys Med Rehabil. 2021;67(2):129-45.
- Pan Y, Guan H, Zhou S, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China. Eur Radiol. 2020;30(6):3306-3309.
- Calabrese M, Garofano M, Palumbo R, et al. Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art. Life (Basel). 2021;11(3):259. Published 2021 Mar 21.
- Zhu C, Wu Y, Liu H, et al. Early pulmonary rehabilitation for SARS-CoV-2 pneumonia: Experience from an intensive care unit outside of the Hubei province in China. Heart Lung. 2020;49(5):449-450.
- Alhazzani W, Møller MH, Arabi YM, et al. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med. 2020;46(5):854-887.
- Yang LL, Yang T. Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19). Chronic Dis Transl Med.2020;6(2):79-86.
- Shah W, Hillman T, Playford ED, et al. Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline. BMJ. 2021;372:136.
- HAS. Rapid responses in the context of COVID-19-Management of post-COVID-19 patients in Physical Medicine and Rehabilitation units (MPR), in Follow-on Care and Rehabilitation units (SSR) and on return home. https://www.has-sante.fr/jcms/p_3179826/en/management-of-covid-patients-in-physical-medicine-and-rehabilitation-mpr-and-on-return-home. 16 April 2020’de basıldı. Erişim Tarihi:10.04.2022.
- Greenhalgh T, Knight M, A’Court C, et al. Management of post-acute covid-19 in primary care. BMJ. 2020; 370: m3026.
- 26.Inoue S, Hatakeyama J, Kondo Y, et al. Post-intensive care syndrome: its pathophysiology, prevention, and future directions. Acute Med Surg. 2019;6(3):233-246.
- Sheehy LM. Considerations for Postacute Rehabilitation for Survivors of COVID-19. JMIR Public Health Surveill. 2020;6(2):e19462.
- Solomen S, Aaron P. Breathing techniques-a review-25 different types breathing techniques-A review. International Journal of Physical Education, Sports and Health 2015;2(2):237-241.
- Muchiri WA, Olutende OM, Kweyu IW, et al. Meaning of Physical Activities for the Elderly: A Review. Am J Sports Sci Med. 2018;6:79-83.
- Lee PG, Jackson EA, Richardson CR. Exercise Prescriptions in Older Adults. Am Fam Physician. 2017; 95(7):425-432.
- Soygüden A, Cerit E. Yaşlılar İçin Egzersiz Uygulamalarının Önemi. Hitit Üniversitesi Sosyal Bilimler Enstitüsü Dergisi. 2015;8(1):197-224.
- Department of Health Australian Government. Recommendations on physical activity for health for older Australians. https://www1.health.gov.au/internet/main/publishing.nsf/Content/phd-physical-rec-older-guidelines. Published:07.05.2021. Erişim Tarihi: 06.04.2022.
- World Health Organization Guideline. Global Recommendations and Physical Activity for Health. Age Group 65 Years Old and Above. https://iris.who.int/bitstream/handle/10665/44399/9789241599979_eng.pdf?sequence=1 Published:2010. Erişim Tarihi:18.01.2024.
- Bao R, Chen ST, Wang Y, et al. Sedentary Behavior Research in the Chinese Population: A Systematic Scoping Review. Int J Environ Res Public Health. 2020;17(10):3576. Published 2020 May 20.
- Jiménez-Pavón D, Carbonell-Baeza A, Lavie CJ. Physical exercise as therapy to fight against the mental and physical consequences of COVID-19 quarantine: Special focus in older people. Prog Cardiovasc Dis. 2020;63(3):386-388.
- Salar S, Akel S. Covid-19 ve Ergoterapi: Salgın Hastalıklara Hızlı Cevap Verme ve Hazırlıklı Olma Boyutuyla Bir Gözden Geçirme Çalışması. Ergoterapi ve Rehabilitasyon Dergisi. 2020;8(2):161-174.
- Ceravolo MG, de Sire A, Andrenelli E, et al. Systematic rapid “living” review on rehabilitation needs due to COVID-19: update to March 31st, 2020. Eur J Phys Rehabil Med. 2020;56(3):347-353.
- Bostrom J, Sweeney G, Whiteson J, et al. Mobile health and cardiac rehabilitation in older adults. Clin Cardiol. 2020;43(2):118-126.
- Schumacher S, Kent N. Eight charts on internet use around the world as countries grapple with COVID-19. Pew Research Center. https://www.pewresearch.org/fact-tank/2020/04/02/8-charts-on-internet-use-around-the-world-as-countries-grapple-with-covid-19/ Published:02.04.2020 Erişim Tarihi:11.10.2023.
- Feng Z, Lugtenberg M, Franse C, et al. Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: A systematic review of longitudinal studies. PLoS One. 2017;12(6):e0178383.
- Hewitt J, Carter B, Vilches-Moraga A, et al. The effect of frailty on survival in patients with COVID-19 (COPE): A multicentre, European, observational cohort study. Lancet Public Health. 2020;5(8):e444-e451.
- Steinman MA, Perry L, Perissinotto CM. Meeting the Care Needs of Older Adults Isolated at Home During the COVID-19 Pandemic. JAMA Intern Med. 2020;180(6):819-820.
- Gropper S, Hunt D, Chapa DW. Sarcopenia and Psychosocial Variables in Patients in Intensive Care Units: The Role of Nutrition and Rehabilitation in Prevention and Treatment. Crit Care Nurs Clin North Am. 2019;31(4):489-499.
- Volkert D, Beck AM, Cederholm T, et al. Management of Malnutrition in Older Patients-Current Approaches, Evidence and Open Questions. J Clin Med. 2019;8(7):974.
- Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772.
- Cheng HM, Koutsidis G, Lodge JK, et al. Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence. Crit Rev Food Sci Nutr. 2019;59(1):141-158.
- Muir SW, Montero-Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: A systematic review and meta-analysis. J Am Geriatr Soc. 2011;59(12):2291-2300.
- Azzolino D, Damanti S, Bertagnoli L, et al. Sarcopenia and swallowing disorders in older people. Aging Clin Exp Res. 2019;31(6):799-805.
- Szanton S, Leff B, Wolff J, et al. Home-Based Care Program Reduces Disability and Promotes Aging In Place. Health Aff (Millwood). 2016;35(9):1558-1563.
- Said CM, Batchelor F, Duque G. Physical Activity and Exercise for Older People During and After the Coronavirus Disease 2019 Pandemic: A Path to Recovery. J Am Med Dir Assoc. 2020;21(7):977-979.
- Karadakovan A. Yaşlı Sağlığı ve Bakım. 1. Baskı. Ankara, Akademisyen Tıp Kitabevi, 2014, 340-359.
- Akarsu R, Bumin G. Ergoterapi Alanında Telerehabilitasyon Uygulamalarının Etkinliği. Türkiye Klinikleri Sağlık Bilimleri Dergisi. 2021;6(3):682-694.
- Hayes D. Telerehabilitation for Older Adults, Topics in Geriatric Rehabilitation. 2020;36(4):205-211.
- Cerqueira-Silva T, Oliveira VA, Boaventura VS, et al. Influence of age on the effectiveness and duration of protection of Vaxzevria and CoronaVac vaccines: A population-based study. The Lancet Regional Health-Americas. 2022;6:100154.
- Cohen SA, Kellogg C, Equils O. Neutralizing and cross-reacting antibodies: implications for immunotherapy and SARS-CoV-2 vaccine development. Human vaccines & immunotherapeutics, 2021;17(1), 84-87.
- Collier DA, Ferreira IATM, Kotagiri P, et al. Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature. 2021;596(7872):417-422.
- Mazagatos C, Monge S, Olmedo C, et al. Effectiveness of mRNA COVID-19 vaccines in preventing SARS-CoV-2 infections and COVID-19 hospitalisations and deaths in elderly long-term care facility residents, Spain, weeks 53 2020 to 13 2021. Euro Surveill. 2021;26(24):2100452.