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EFFECTS OF VINEGAR ON HEALTH

Year 2019, , 1042 - 1058, 06.10.2019
https://doi.org/10.15237/gida.GD19079

Abstract

Health effects observed due to vinegar consumption date
back to about 10000 years ago. Firstly, as the founder of medicine, it was
stated by Hippocrates that the vinegar could be beneficial for health. Various
treatments for vinegar have been developed in the traditional medicine since
the Hippocrates. With the development of modern medicine and its practice
tools, various important studies carried out on consumption of vinegar and its
impacts on health. In this 
article,
scientific studies carried out between the period of 2009-2019 about the
effects of vinegar consumption on health were reviewed. In this context, the
glycemic effect of vinegar, its anti-diabetic effect, its effect on fat
metabolism, its effect on ulcerative colitis, its effect on cholesterol, its
effects on liver and function, its effect on oxidative stress, its effect on
cancer and its antimicrobial effect were investigated. As a result, vinegar
consumption is conceivable to have an important place in healthy nutrition.

References

  • Abe, K., Kushibiki, T., Matsue, H., Furukawa, K. I., & Motomura, S. (2007). Generation of antitumor active neutral medium-sized α-glycan in apple vinegar fermentation. Bioscience, Biotechnology, and Biochemistry, 71(9), 2124-2129.
  • Akbaş, M., & Cabaroğlu, T. (2010). Ülkemizde üretilen bazı üzüm sirkelerinin bileşimleri ve gıda mevzuatına uygunlukları üzerine bir araştırma. Gıda, 35(3), 183-188.
  • Ali, Z., Ma, H., Ayim, I., & Wali, A. (2018a). Efficacy of new beverage made of dates vinegar and garlic juice in improving serum lipid profile parameters and inflammatory biomarkers of mildly hyperlipidemic adults: A double-blinded, randomized, placebo-controlled study. Journal of Food Biochemistry, 42(5), e12545. doi:10.1111/jfbc.12545
  • Ali, Z., Ma, H., Wali, A., Ayim, I., Rashid, M. T., & Younas, S. (2018b). A double-blinded, randomized, placebo-controlled study evaluating the impact of dates vinegar consumption on blood biochemical and hematological parameters in patients with type 2 diabetes. Tropical Journal of Pharmaceutical Research, 17(12), 2463-2469. doi:http://dx.doi.org/10.4314/tjpr.v17i12.23
  • Ali, Z., Ma, H., Wali, A., Ayim, I., & Sharif, M. N. (2019). Daily date vinegar consumption improves hyperlipidemia, β- carotenoid and inflammatory biomarkers in mildly hypercholesterolemic adults. Journal of Herbal Medicine, 100265. doi:https://doi.org/10.1016/j.hermed.2019.100265
  • Altunbağ, E., & Zencir, E. (2018). Türk ve Akdeniz yemeklerinde sirke kullanımı. Journal of Gastronomy, Hospitality and Travel, 1(2), 45-54.
  • Anonim. (2009). Türkiye'de kanser kontrolü, Editör: A. Murat, Tuncer. Ankara, T.C. Sağlık Bakanlığı Kanserle Savaş Dairesi Başkanlığı. Retrieved from
  • Anonim. (2014). Türkiye kanser istatistikleri. Sağlık Bakanlığı, Türkiye Halk Sağlığı Kurumu, Ankara.
  • Atik, D., Atik, C. & Karatepe C. (2016). The effect of external apple vinegar application on varicosity symptoms, pain, and social appearance anxiety: A randomized controlled trial, Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 6473678, 8 pages. https://doi.org/10.1155/2016/6473678.
  • Baldas, B., & Altuner, E. M. (2018). The antimicrobial activity of apple cider vinegar and grape vinegar, which are used as a traditional surface disinfectant for fruits and vegetables. Commun. Fac. Sci. Univ. Ank. Series C, 27(1), 1-10. doi: 10.1501/commuc_0000000187
  • Bayrak, M., E. 2014. Diyabette "Tıbbi Beslenme Tedavisi". Ekonomik Forum. 246, 34-35.
  • Beh, B. K., Mohamad, N. E., Yeap, S. K., Ky, H., Boo, S. Y., Chua, J. Y. H., Alitheen, N. B. (2017). Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice. Scientific Reports, 7(1), 6664. doi:10.1038/s41598-017-06235-7
  • Bozdemir, E., & Taşlı, M. (2018). Hastalık maliyet analizinin bibliyometrik ve doküman açısından incelemesi. Konuralp Tıp Dergisi, 10(3), 408-419.
  • Budak, H. N., & Güzel-Seydim, Z. B. (2010). Sirke üretimi ve bazı fonksiyonel özellikleri. Gıda Teknolojisi, 14(11), 85-88.
  • Budak, N. H., Aykin, E., Seydim, A. C., Greene, A. K., & Guzel-Seydim, Z. B. (2014). Functional properties of vinegar. Journal of Food Science, 79(5), R757-R764. doi: 10.1111/1750-3841.12434.
  • Budak, N. H., Kumbul Doguc, D., Savas, C. M., Seydim, A. C., Kok Tas, T., Ciris, M. I., & Guzel-Seydim, Z. B. (2011). Effects of apple cider vinegars produced with different techniques on blood lipids in high-cholesterol-fed rats. Journal of Agricultural and Food Chemistry, 59(12), 6638-6644. doi:10.1021/jf104912h
  • Bulutlar, O. N. (2015). Diyabet hastalarına beslenme açısından yaklaşım. Okmeydanı Tıp Dergisi, 31(Ek sayı), 39-44. doi:10.5222/otd.2015.039
  • Chen, H., Chen, T., Giudici, P., & Chen, F. (2016). Vinegar functions on health: Constituents, sources, and formation mechanisms. Comprehensive Reviews in Food Science and Food Safety, 15(6), 1124-1138. doi:10.1111/1541-4337.12228
  • Chen, J., Tian, J., Ge, H., Liu, R., & Xiao, J. (2017). Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells. Food and Chemical Toxicology, 109, 930-940. doi:https://doi.org/10.1016/j.fct.2016.12.017
  • Chou, C.-H., Liu, C.-W., Yang, D.-J., Wu, Y.-H. S., & Chen, Y.-C. (2015). Amino acid, mineral, and polyphenolic profiles of black vinegar, and its lipid lowering and antioxidant effects in vivo. Food Chemistry, 168, 63-69. doi:https://doi.org/10.1016/j.foodchem.2014.07.035
  • Doğer, L., & Armağan, E. (2014). Bizans döneminde Prousa (Bursa) ve çevresinde gündelik beslenme üzerine bir deneme. Sanat Tarihi Dergisi, 23(2), 13-48.
  • Ghazzi, M., Porto-Fett, A. C. S., Ayaz, N. D., Ozansoy, G., Çufaoğlu, G., Goncuoglu, M., Luchansky, J. B. (2018). Microbiological characterization of çiğ köfte sold at retail in Ankara, Turkey, and evaluation of selected antimicrobials as ingredients to control foodborne pathogens in çiğ köfte during refrigerated storage. Food Control, 84, 138-147. doi:https://doi.org/10.1016/j.foodcont.2017.04.033
  • Halima, B. H., Sonia, G., Sarra, K., Houda, B. J., Fethi, B. S., & Abdallah, A. (2018). Apple cider vinegar attenuates oxidative stress and reduces the risk of obesity in high-fat-fed male Wistar rats. Journal of Medicinal Food, 21(1), 70-80. https://doi.org/10.1089/jmf.2017.0039
  • Henley, S. C., Launchi, N., & Quinlan, J. J. (2018). Survival of Salmonella on raw poultry exposed to 10% lemon juice and vinegar washes. Food Control, 94, 229-232.
  • Ho, C. W., Lazim, A. M., Fazry, S., Zaki, U. K. H. H., & Lim, S. J. (2017). Varieties, production, composition and health benefits of vinegars: A review. Food Chemistry, 221, 1621-1630.
  • Kako, J., Kobayashi, M., Kanno, Y., & Tagami, K. (2017). Intranasal vinegar as an effective treatment for persistent hiccups in a patient with advanced cancer undergoing palliative care. Journal of Pain and Symptom Management, 54(2), e2-e4. doi:10.1016/j.jpainsymman.2017.02.011
  • Karim, N., Jeenduang, N., & Tangpong, J. (2018). Anti-glycemic and anti-hepatotoxic effects of Mangosteen vinegar rind from garcinia mangostana against HFD/STZ-induced type II diabetes in mice. Pol. J. Food Nutr. Sci, 68(2), 163. doi:https://doi.org/10.1515/pjfns-2017-0018
  • Kausar, S., Abbas, M., A., Ahmad H., Yousef N., Ahmed Z., Humayun N., Ashfaq H. & Humayun, A. (2019). Effect of Apple Cider Vinegar in Type 2 Diabetic Patients with Poor Glycemic Control: A Randomized Placebo Controlled Design. International Journal of Medical Research & Health Sciences, 8(2): 149-159
  • Khezri, S. S., Saidpour, A., Hosseinzadeh, N., & Amiri, Z. (2018). Beneficial effects of apple cider vinegar on weight management, visceral adiposity index and lipid profile in overweight or obese subjects receiving restricted calorie diet: A randomized clinical trial. Journal of Functional Foods, 43, 95-102. doi:https://doi.org/10.1016/j.jff.2018.02.003
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  • Merdol, T. K. (2016). Beslenme ve diyetetik biliminin dünü, bugünü ve geleceği. İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 1(1), 1-5.
  • Mitrou, P., Petsiou, E., Papakonstantinou, E., Maratou, E., Lambadiari, V., Dimitriadis, P., Dimitriadis, G. (2015). The role of acetic acid on glucose uptake and blood flow rates in the skeletal muscle in humans with impaired glucose tolerance. European Journal Of Clinical Nutrition, 69, 734. doi:10.1038/ejcn.2014.289
  • Mohamad, N. E., Yeap, S. K., Abu, N., Lim, K. L., Zamberi, N. R., Nordin, N., Alitheen, N. B. (2019). In vitro and in vivo antitumour effects of coconut water vinegar on 4T1 breast cancer cells. Food & Nutrition Research, 63(1616). doi:https://doi.org/10.29219/fnr.v63.1616
  • Mohamad, N. E., Yeap, S. K., Beh, B.-K., Ky, H., Lim, K. L., Ho, W. Y., Alitheen, N. B. (2018). Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice. BMC Complementary and Alternative Medicine, 18(1), 195. doi:10.1186/s12906-018-2199-4
  • Mohammadghasemi, F., Abbasi, M., Rudkhaneei, K., & Aghajany-Nasab, M. (2018). Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease. Andrologia, 50(8), e13065. doi:10.1111/and.13065
  • Mota, A. C., Castro, R. D., Araújo Oliveira, J. & Oliveira Lima, E. (2015), Antifungal activity of apple cider vinegar on candida species ınvolved in denture stomatitis. Journal of Prosthodontics, 24: 296-302. doi:10.1111/jopr.12207
  • Öztürk, S. (2015). Kara havuçtan sirke üretimi üzerine araştırma. (Yüksek Lisans Tezi), Ankara Üniversitesi, Ankara
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  • Seydim, A. C., Guzel-Seydim, Z. B., Doguc, D. K., Savas, M. C., & Budak, H. N. (2016). Effects of grape wine and apple cider vinegar on oxidative and antioxidative status in high cholesterol-fed rats. Functional Foods in Health and Disease, 6(9), 569-577.
  • Shen, F., Feng, J., Wang, X., Qi, Z., Shi, X., An, Y., Liu, B. (2016). Vinegar treatment prevents the development of murine experimental colitis via inhibition of inflammation and apoptosis. Journal of Agricultural and Food Chemistry, 64(5), 1111-1121. doi:10.1021/acs.jafc.5b05415
  • Shields, L. B. E., Rolf, C. M., & Hunsaker, J. C. (2016). Sudden death due to forced ingestion of vinegar. Forensic Science International, 266, e23-e26. doi:https://doi.org/10.1016/j.forsciint.2016.06.031
  • Shishehbor, F., Mansoori, A., & Shirani, F. (2017). Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials. Diabetes Research and Clinical Practice, 127, 1-9. doi:https://doi.org/10.1016/j.diabres.2017.01.021
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SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ

Year 2019, , 1042 - 1058, 06.10.2019
https://doi.org/10.15237/gida.GD19079

Abstract

Sirke tüketimine bağlı olarak gözlemlenen olumlu sağlık
etkileri yaklaşık 10 bin yıl öncesine kadar dayanmaktadır. İlk defa, tıbbın
kurucusu olarak atfedilen Hipokrat tarafından sirkenin sağlığa faydalı
olabileceği belirtilmiştir. Hipokrat döneminden bu yana geleneksel tıpta,
sirkeye bağlı uygulanan çeşitli tedaviler geliştirilmiştir. Modern tıbbın ve
uygulama araçlarının gelişmesi ile sirke tüketiminin sağlık üzerine olan
etkileri hakkında çeşitli önemli çalışmalar yürütülmüştür. Yapılan bu derleme
çalışmasında, 2009-2019 yılları arasında sirke tüketiminin sağlık üzerine
etkileri konusunda gerçekleştirilmiş araştırmalar sunulmuştur. Bu kapsamda,
sirkenin glisemik, anti-diyabetik, yağ metabolizması üzerine, ülseratif-kolit üzerine,
kolestrol üzerine, karaciğer ve fonksiyonları üzerine, oksidatif stres,
anti-kanserojen ve antimikrobiyel etkileri incelenmiştir. Sonuç olarak, sirke
tüketiminin sağlıklı beslenme anlayışı içinde önemli bir yerinin bulunduğu
düşünülmektedir.

References

  • Abe, K., Kushibiki, T., Matsue, H., Furukawa, K. I., & Motomura, S. (2007). Generation of antitumor active neutral medium-sized α-glycan in apple vinegar fermentation. Bioscience, Biotechnology, and Biochemistry, 71(9), 2124-2129.
  • Akbaş, M., & Cabaroğlu, T. (2010). Ülkemizde üretilen bazı üzüm sirkelerinin bileşimleri ve gıda mevzuatına uygunlukları üzerine bir araştırma. Gıda, 35(3), 183-188.
  • Ali, Z., Ma, H., Ayim, I., & Wali, A. (2018a). Efficacy of new beverage made of dates vinegar and garlic juice in improving serum lipid profile parameters and inflammatory biomarkers of mildly hyperlipidemic adults: A double-blinded, randomized, placebo-controlled study. Journal of Food Biochemistry, 42(5), e12545. doi:10.1111/jfbc.12545
  • Ali, Z., Ma, H., Wali, A., Ayim, I., Rashid, M. T., & Younas, S. (2018b). A double-blinded, randomized, placebo-controlled study evaluating the impact of dates vinegar consumption on blood biochemical and hematological parameters in patients with type 2 diabetes. Tropical Journal of Pharmaceutical Research, 17(12), 2463-2469. doi:http://dx.doi.org/10.4314/tjpr.v17i12.23
  • Ali, Z., Ma, H., Wali, A., Ayim, I., & Sharif, M. N. (2019). Daily date vinegar consumption improves hyperlipidemia, β- carotenoid and inflammatory biomarkers in mildly hypercholesterolemic adults. Journal of Herbal Medicine, 100265. doi:https://doi.org/10.1016/j.hermed.2019.100265
  • Altunbağ, E., & Zencir, E. (2018). Türk ve Akdeniz yemeklerinde sirke kullanımı. Journal of Gastronomy, Hospitality and Travel, 1(2), 45-54.
  • Anonim. (2009). Türkiye'de kanser kontrolü, Editör: A. Murat, Tuncer. Ankara, T.C. Sağlık Bakanlığı Kanserle Savaş Dairesi Başkanlığı. Retrieved from
  • Anonim. (2014). Türkiye kanser istatistikleri. Sağlık Bakanlığı, Türkiye Halk Sağlığı Kurumu, Ankara.
  • Atik, D., Atik, C. & Karatepe C. (2016). The effect of external apple vinegar application on varicosity symptoms, pain, and social appearance anxiety: A randomized controlled trial, Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 6473678, 8 pages. https://doi.org/10.1155/2016/6473678.
  • Baldas, B., & Altuner, E. M. (2018). The antimicrobial activity of apple cider vinegar and grape vinegar, which are used as a traditional surface disinfectant for fruits and vegetables. Commun. Fac. Sci. Univ. Ank. Series C, 27(1), 1-10. doi: 10.1501/commuc_0000000187
  • Bayrak, M., E. 2014. Diyabette "Tıbbi Beslenme Tedavisi". Ekonomik Forum. 246, 34-35.
  • Beh, B. K., Mohamad, N. E., Yeap, S. K., Ky, H., Boo, S. Y., Chua, J. Y. H., Alitheen, N. B. (2017). Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice. Scientific Reports, 7(1), 6664. doi:10.1038/s41598-017-06235-7
  • Bozdemir, E., & Taşlı, M. (2018). Hastalık maliyet analizinin bibliyometrik ve doküman açısından incelemesi. Konuralp Tıp Dergisi, 10(3), 408-419.
  • Budak, H. N., & Güzel-Seydim, Z. B. (2010). Sirke üretimi ve bazı fonksiyonel özellikleri. Gıda Teknolojisi, 14(11), 85-88.
  • Budak, N. H., Aykin, E., Seydim, A. C., Greene, A. K., & Guzel-Seydim, Z. B. (2014). Functional properties of vinegar. Journal of Food Science, 79(5), R757-R764. doi: 10.1111/1750-3841.12434.
  • Budak, N. H., Kumbul Doguc, D., Savas, C. M., Seydim, A. C., Kok Tas, T., Ciris, M. I., & Guzel-Seydim, Z. B. (2011). Effects of apple cider vinegars produced with different techniques on blood lipids in high-cholesterol-fed rats. Journal of Agricultural and Food Chemistry, 59(12), 6638-6644. doi:10.1021/jf104912h
  • Bulutlar, O. N. (2015). Diyabet hastalarına beslenme açısından yaklaşım. Okmeydanı Tıp Dergisi, 31(Ek sayı), 39-44. doi:10.5222/otd.2015.039
  • Chen, H., Chen, T., Giudici, P., & Chen, F. (2016). Vinegar functions on health: Constituents, sources, and formation mechanisms. Comprehensive Reviews in Food Science and Food Safety, 15(6), 1124-1138. doi:10.1111/1541-4337.12228
  • Chen, J., Tian, J., Ge, H., Liu, R., & Xiao, J. (2017). Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells. Food and Chemical Toxicology, 109, 930-940. doi:https://doi.org/10.1016/j.fct.2016.12.017
  • Chou, C.-H., Liu, C.-W., Yang, D.-J., Wu, Y.-H. S., & Chen, Y.-C. (2015). Amino acid, mineral, and polyphenolic profiles of black vinegar, and its lipid lowering and antioxidant effects in vivo. Food Chemistry, 168, 63-69. doi:https://doi.org/10.1016/j.foodchem.2014.07.035
  • Doğer, L., & Armağan, E. (2014). Bizans döneminde Prousa (Bursa) ve çevresinde gündelik beslenme üzerine bir deneme. Sanat Tarihi Dergisi, 23(2), 13-48.
  • Ghazzi, M., Porto-Fett, A. C. S., Ayaz, N. D., Ozansoy, G., Çufaoğlu, G., Goncuoglu, M., Luchansky, J. B. (2018). Microbiological characterization of çiğ köfte sold at retail in Ankara, Turkey, and evaluation of selected antimicrobials as ingredients to control foodborne pathogens in çiğ köfte during refrigerated storage. Food Control, 84, 138-147. doi:https://doi.org/10.1016/j.foodcont.2017.04.033
  • Halima, B. H., Sonia, G., Sarra, K., Houda, B. J., Fethi, B. S., & Abdallah, A. (2018). Apple cider vinegar attenuates oxidative stress and reduces the risk of obesity in high-fat-fed male Wistar rats. Journal of Medicinal Food, 21(1), 70-80. https://doi.org/10.1089/jmf.2017.0039
  • Henley, S. C., Launchi, N., & Quinlan, J. J. (2018). Survival of Salmonella on raw poultry exposed to 10% lemon juice and vinegar washes. Food Control, 94, 229-232.
  • Ho, C. W., Lazim, A. M., Fazry, S., Zaki, U. K. H. H., & Lim, S. J. (2017). Varieties, production, composition and health benefits of vinegars: A review. Food Chemistry, 221, 1621-1630.
  • Kako, J., Kobayashi, M., Kanno, Y., & Tagami, K. (2017). Intranasal vinegar as an effective treatment for persistent hiccups in a patient with advanced cancer undergoing palliative care. Journal of Pain and Symptom Management, 54(2), e2-e4. doi:10.1016/j.jpainsymman.2017.02.011
  • Karim, N., Jeenduang, N., & Tangpong, J. (2018). Anti-glycemic and anti-hepatotoxic effects of Mangosteen vinegar rind from garcinia mangostana against HFD/STZ-induced type II diabetes in mice. Pol. J. Food Nutr. Sci, 68(2), 163. doi:https://doi.org/10.1515/pjfns-2017-0018
  • Kausar, S., Abbas, M., A., Ahmad H., Yousef N., Ahmed Z., Humayun N., Ashfaq H. & Humayun, A. (2019). Effect of Apple Cider Vinegar in Type 2 Diabetic Patients with Poor Glycemic Control: A Randomized Placebo Controlled Design. International Journal of Medical Research & Health Sciences, 8(2): 149-159
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There are 62 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Çağlar Gökırmaklı

Zeynep Banu Guzel-seydim

Havva Nilgün Budak This is me

Publication Date October 6, 2019
Published in Issue Year 2019

Cite

APA Gökırmaklı, Ç., Guzel-seydim, Z. B., & Budak, H. N. (2019). SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ. Gıda, 44(6), 1042-1058. https://doi.org/10.15237/gida.GD19079
AMA Gökırmaklı Ç, Guzel-seydim ZB, Budak HN. SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ. GIDA. October 2019;44(6):1042-1058. doi:10.15237/gida.GD19079
Chicago Gökırmaklı, Çağlar, Zeynep Banu Guzel-seydim, and Havva Nilgün Budak. “SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ”. Gıda 44, no. 6 (October 2019): 1042-58. https://doi.org/10.15237/gida.GD19079.
EndNote Gökırmaklı Ç, Guzel-seydim ZB, Budak HN (October 1, 2019) SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ. Gıda 44 6 1042–1058.
IEEE Ç. Gökırmaklı, Z. B. Guzel-seydim, and H. N. Budak, “SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ”, GIDA, vol. 44, no. 6, pp. 1042–1058, 2019, doi: 10.15237/gida.GD19079.
ISNAD Gökırmaklı, Çağlar et al. “SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ”. Gıda 44/6 (October 2019), 1042-1058. https://doi.org/10.15237/gida.GD19079.
JAMA Gökırmaklı Ç, Guzel-seydim ZB, Budak HN. SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ. GIDA. 2019;44:1042–1058.
MLA Gökırmaklı, Çağlar et al. “SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ”. Gıda, vol. 44, no. 6, 2019, pp. 1042-58, doi:10.15237/gida.GD19079.
Vancouver Gökırmaklı Ç, Guzel-seydim ZB, Budak HN. SİRKENİN SAĞLIK ÜZERİNE ETKİLERİ. GIDA. 2019;44(6):1042-58.

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