BİYOAKTİF PEPTİTLERİN SAĞLIK ÜZERİNE ETKİLERİ

Year 2018, Volume: 43 Issue: 6, 930 - 942, 01.11.2018

Mustafa Ümit Ünal , Aysun Şener , Kardelen Cemek

https://doi.org/10.15237/gida.GD18048

Cited By: 1

Abstract

Biyoaktif peptitler aminoasitlerin peptit bağlarıyla
bağlanması sonucu oluşan, vücut fonksiyonlarına olumlu etkisi olan ve sağlığı
etkileyebilen spesifik protein parçalarıdır. Bazı biyoaktif peptitler doğal
kaynaklarında serbest olarak bulunurlar. Ancak, bilinen biyoaktif peptitlerin
büyük çoğunluğu ana proteinlerin yapısı içerisinde inaktif halde bulunurlar ve
proteolitik enzimlerle hidroliz veya fermantasyon sonucu serbest kalırlar.
Biyoaktif peptitler, sindirim, endokrin, kardiyovasküler, bağışıklık ve sinir
sistemini ve dolayısıyla insan sağlığını etkilerler. In vitro ve in
vivo çalışmalarda antimikrobiyal, antitrombotik, antihipertansif, opioid,
immünomodülatör, kolesterol düşürücü, mineral bağlayıcı ve antioksidatif
özellikler gösterdikleri ortaya konmuştur. Bu derlemede biyoaktif peptitlerin
tanımlanması, kaynakları, biyoaktif özellikleri ve sağlık üzerine etkileri ele
alınmıştır.

Keywords

Proteinler, Peptitler, Biyoaktivite, Biyoaktif Peptit Kaynakları, Sağlık

EFFECTS OF BIOACTIVE PEPTIDES ON HEALTH

Abstract

Bioactive peptides are formed by amino acids joined by peptide bonds and defined as specific protein fragments that have a positive impact on body functions, and may influence health. Some bioactive peptides exist free in its natural source. However,  the vast majority of known bioactive peptides are inactive within the structure of the parent proteins and are released by enzymic hydrolysis or fermentation. Bioactive peptides play a significant role in human health by affecting the digestive, endocrine, cardiovascular, immune, and nervous systems. In vitro and in vivo studies showed that bioactive peptides exhibited antimicrobial, antithrombotic, antihypertensive, opioid, immunomodulator, cholesterol lowering, mineral binding and antioxidant roperties. In this review, identification, sources, bioactive properties and health effects of bioactive peptides are addressed.

Keywords

Proteins, Peptides, Bioactivity, Bioactive Peptide Sources, Health

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