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B12 vitamini eksikliği olan çocuklarda Helicobacter pylori sıklığının araştırılması

Year 2015, Volume: 5 Issue: 4, 221 - 225, 21.02.2016

İshak Işık , Cahit Erdur , Ufuk Bozkurt Obuz Nur Arslan

Abstract

B12 vitamin eksikliğinin beslenme bozukluklarının yanı sıra, en önemli nedenlerinden biri malabsorpsiyondur. Helicobacter pylori (HP) bazı çalışmalarda B12 eksikliği ile ilişkili bulunmuştur. Bu çalışmanın amacı, B12 eksikliği saptanan çocuklarda HP sıklığının araştırılmasıdır.

Çalışmaya 24 hasta (ortalama yaş: 15.6 ± 1.3 yıl) dâhil edildi. B12 vitamini düzeyi elektrokemiluminesens immunoassay yöntemi ile ölçüldü. Tüm hastalara üst gastrointestinal sistem endoskopisi yapılarak hızlı üreaz testi yapıldı ve histopatolojik inceleme yapıldı.

Hastaların 15’i (%62.5) nörolojik bulgular ile başvururken, 6 (%25.0) hastada halsizlik ve yorgunluk şikâyetleri mevcuttu. Üç (%12.5) hasta ise başka nedenlerle tetkik edilirken B12 vitamini eksikliği saptanmıştı. Üç farklı tablo ile başvuran hastaların B12 vitamini düzeyleri arasında anlamlı fark saptanmadı (p=0.224). Hastaların 18’inde (%75) HP pozitif saptandı. HP pozitif hastaların ortalama B12 vitamini düzeyi 108.6 ± 31.1 pg/mL iken, HP negatif hastalarda 113.5 ± 41.2 pg/mL saptandı (p=973).

Sonuç olarak B12 vitamini eksikliği saptanan hastalarda, B12 vitamini eksikliğinin önemli bir nedeni olan HP enfeksiyonu araştırılmalı ve pozitif saptanan hastalar tedavi edilmelidir.

Keywords

B12 vitamini Helicobacter pylori çocuk

References

  • Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med 1996;100:125-175.
  • Rothenbacher D, Brenner H. Burden of helicobacter pylori and H.pylori –related diseases in developed countries: recent developments and future implications. Microbes Infect 2003;5:693-703.
  • Akçam M. Helicobacter pylori and micronutrients. Indian Pediatr 2010;47:119-126.
  • Ayesh MH, Jadalah K, Al Awadi E, Alawneh K, Khassawneh B. Association between vitamin B12 level and anti-parietal cells and anti-intrinsic factor antibodies among adult Jordanian patients with Helicobacter pylori infection. Braz J Infect Dis 2013;17:629-632.
  • Khedmat H, Amini M, Karbasi A, Azizi R. The effect of Helicobacter pylori on vitamin B 12 blood levels in chronic renal failure patients: a single blind control trial. Saudi J Kidney Dis Transpl 2013;24:7597-63.
  • Gowdappa HB, Mahesh M, Murthy KV, Narahari MG. Helicobacter pylori associated vitamin B12 deficiency, pernicious anaemia and subacute combined degeneration of the spinal cord. BMJ Case Rep 2013;2013. doi: 10.1136/bcr-2013-200380.
  • Taş DA, Yakar T, Sakalli H, Serin E. Impact of Helicobacter pylori on the clinical course of recurrent aphthous stomatitis. J Oral Pathol Med 2013;42:89-94.
  • Sarari AS, Farraj MA, Hamoudi W, Essawi TA. Helicobacter pylori, a causative agent of vitamin B12 deficiency. J Infect Dev Ctries 2008;2:346-349.
  • Akcam M, Ozdem S, Yilmaz A, Gultekin M, Artan R. Serum ferritin, vitamin B(12), folate, and zinc levels in children infected with Helicobacter pylori. Dig Dis Sci 2007;52:405-410.
  • Dali-Youcef N, Andre E. An update on cobalamin deficiency in adults. Q J Med 2009; 102:17–28.
  • Scott JM. Bioavailability of vitamin B12. Eur J Clin Nutr 1997;51(Suppl.):49-53.
  • O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients 2010;2:299-316.
  • Sobala GM, Crabtree JE, Dixon MF, Schorah CJ, Taylor JD, Rathbone BJ, et al. Acute Helicobacter pylori infection; clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentration. Gut 1991;32:1415–1418.
  • Veijola LI, Oksanen AM, Sipponen PI, Rautelin HI. Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection. World J Gastroenterol 2010;16:83-88.
  • Anitha P, Sasitharan R, Thambarasi T, Krithika P, Mohan M, Venkataraman P, et al. Vitamin B12 deficiency presenting as pancytopenia and retinopathy in a young boy-Helicobacter pylori, a novel causative agent. Australas Med J 2014;7:143-148.
  • Bay A, Coskun E, Leblebisatan G, Yalcin AS. Helicobacter pylori infection-related pancytopenia in a young boy. Pediatr Hematol Oncol 2011;28:733-735.
  • Thankachan P, Muthayya S, Sierksma A, Eilander A, Thomas T, Duchateau GS, et al. Helicobacter pylori infection does not influence the efficacy of iron and vitamin B(12) fortification in marginally nourished Indian children. Eur J Clin Nutr 2010;64:1101-1107.
  • Rasool S, Abid S, Iqbal MP, Mehboobali N, Haider G, Jafri W. Relationship between vitamin B12, folate and homocysteine levels and H. pylori infection in patients with functional dyspepsia: a cross-section study. BMC Res Notes 2012;5:206. doi: 10.1186/1756-0500-5-206.
  • Oussalah A, Besseau C, Chery C, Jeannesson E, Guéant-Rodriguez RM, Anello G, et al. Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G->A) and vitamin B-12 in Europe and West Africa. Am J Clin Nutr 2012;95:514-521.
  • Kaptan K, Beyan C, Ural AU, Cetin T, Avcu F, Gülşen M, et al. Helicobacter pylori--is it a novel causative agent in Vitamin B12 deficiency? Arch Intern Med 2000;160:1349-1353.
  • Tamura A, Fujioka T, Nasu M. Relation of Helicobacter pylori infection to plasma vitamin B12, folic acid, and homocysteine levels in patients who underwent diagnostic coronary arteriography. Am J Gastroenterol 2002;97:861-866.
  • Annibale B, Capurso G, Delle Fave G. Consequences of Helicobacter pylori infection on the absorption of micronutrients. Dig Liver Dis 2002;34(Suppl 2):72–77.

Year 2015, Volume: 5 Issue: 4, 221 - 225, 21.02.2016

İshak Işık , Cahit Erdur , Ufuk Bozkurt Obuz Nur Arslan

Abstract

References

  • Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med 1996;100:125-175.
  • Rothenbacher D, Brenner H. Burden of helicobacter pylori and H.pylori –related diseases in developed countries: recent developments and future implications. Microbes Infect 2003;5:693-703.
  • Akçam M. Helicobacter pylori and micronutrients. Indian Pediatr 2010;47:119-126.
  • Ayesh MH, Jadalah K, Al Awadi E, Alawneh K, Khassawneh B. Association between vitamin B12 level and anti-parietal cells and anti-intrinsic factor antibodies among adult Jordanian patients with Helicobacter pylori infection. Braz J Infect Dis 2013;17:629-632.
  • Khedmat H, Amini M, Karbasi A, Azizi R. The effect of Helicobacter pylori on vitamin B 12 blood levels in chronic renal failure patients: a single blind control trial. Saudi J Kidney Dis Transpl 2013;24:7597-63.
  • Gowdappa HB, Mahesh M, Murthy KV, Narahari MG. Helicobacter pylori associated vitamin B12 deficiency, pernicious anaemia and subacute combined degeneration of the spinal cord. BMJ Case Rep 2013;2013. doi: 10.1136/bcr-2013-200380.
  • Taş DA, Yakar T, Sakalli H, Serin E. Impact of Helicobacter pylori on the clinical course of recurrent aphthous stomatitis. J Oral Pathol Med 2013;42:89-94.
  • Sarari AS, Farraj MA, Hamoudi W, Essawi TA. Helicobacter pylori, a causative agent of vitamin B12 deficiency. J Infect Dev Ctries 2008;2:346-349.
  • Akcam M, Ozdem S, Yilmaz A, Gultekin M, Artan R. Serum ferritin, vitamin B(12), folate, and zinc levels in children infected with Helicobacter pylori. Dig Dis Sci 2007;52:405-410.
  • Dali-Youcef N, Andre E. An update on cobalamin deficiency in adults. Q J Med 2009; 102:17–28.
  • Scott JM. Bioavailability of vitamin B12. Eur J Clin Nutr 1997;51(Suppl.):49-53.
  • O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients 2010;2:299-316.
  • Sobala GM, Crabtree JE, Dixon MF, Schorah CJ, Taylor JD, Rathbone BJ, et al. Acute Helicobacter pylori infection; clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentration. Gut 1991;32:1415–1418.
  • Veijola LI, Oksanen AM, Sipponen PI, Rautelin HI. Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection. World J Gastroenterol 2010;16:83-88.
  • Anitha P, Sasitharan R, Thambarasi T, Krithika P, Mohan M, Venkataraman P, et al. Vitamin B12 deficiency presenting as pancytopenia and retinopathy in a young boy-Helicobacter pylori, a novel causative agent. Australas Med J 2014;7:143-148.
  • Bay A, Coskun E, Leblebisatan G, Yalcin AS. Helicobacter pylori infection-related pancytopenia in a young boy. Pediatr Hematol Oncol 2011;28:733-735.
  • Thankachan P, Muthayya S, Sierksma A, Eilander A, Thomas T, Duchateau GS, et al. Helicobacter pylori infection does not influence the efficacy of iron and vitamin B(12) fortification in marginally nourished Indian children. Eur J Clin Nutr 2010;64:1101-1107.
  • Rasool S, Abid S, Iqbal MP, Mehboobali N, Haider G, Jafri W. Relationship between vitamin B12, folate and homocysteine levels and H. pylori infection in patients with functional dyspepsia: a cross-section study. BMC Res Notes 2012;5:206. doi: 10.1186/1756-0500-5-206.
  • Oussalah A, Besseau C, Chery C, Jeannesson E, Guéant-Rodriguez RM, Anello G, et al. Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G->A) and vitamin B-12 in Europe and West Africa. Am J Clin Nutr 2012;95:514-521.
  • Kaptan K, Beyan C, Ural AU, Cetin T, Avcu F, Gülşen M, et al. Helicobacter pylori--is it a novel causative agent in Vitamin B12 deficiency? Arch Intern Med 2000;160:1349-1353.
  • Tamura A, Fujioka T, Nasu M. Relation of Helicobacter pylori infection to plasma vitamin B12, folic acid, and homocysteine levels in patients who underwent diagnostic coronary arteriography. Am J Gastroenterol 2002;97:861-866.
  • Annibale B, Capurso G, Delle Fave G. Consequences of Helicobacter pylori infection on the absorption of micronutrients. Dig Liver Dis 2002;34(Suppl 2):72–77.
There are 22 citations in total.

Details

Primary Language Turkish
Journal Section Original Research
Authors

İshak Işık

Cahit Erdur

Ufuk Bozkurt Obuz This is me

Nur Arslan

Publication Date February 21, 2016
Published in Issue Year 2015 Volume: 5 Issue: 4

Cite

APA Işık, İ., Erdur, C., Bozkurt Obuz, U., Arslan, N. (2016). B12 vitamini eksikliği olan çocuklarda Helicobacter pylori sıklığının araştırılması. Çağdaş Tıp Dergisi, 5(4), 221-225. https://doi.org/10.16899/ctd.77646
AMA Işık İ, Erdur C, Bozkurt Obuz U, Arslan N. B12 vitamini eksikliği olan çocuklarda Helicobacter pylori sıklığının araştırılması. J Contemp Med. February 2016;5(4):221-225. doi:10.16899/ctd.77646
Chicago Işık, İshak, Cahit Erdur, Ufuk Bozkurt Obuz, and Nur Arslan. “B12 Vitamini eksikliği Olan çocuklarda Helicobacter Pylori sıklığının araştırılması”. Çağdaş Tıp Dergisi 5, no. 4 (February 2016): 221-25. https://doi.org/10.16899/ctd.77646.
EndNote Işık İ, Erdur C, Bozkurt Obuz U, Arslan N (February 1, 2016) B12 vitamini eksikliği olan çocuklarda Helicobacter pylori sıklığının araştırılması. Çağdaş Tıp Dergisi 5 4 221–225.
IEEE İ. Işık, C. Erdur, U. Bozkurt Obuz, and N. Arslan, “B12 vitamini eksikliği olan çocuklarda Helicobacter pylori sıklığının araştırılması”, J Contemp Med, vol. 5, no. 4, pp. 221–225, 2016, doi: 10.16899/ctd.77646.
ISNAD Işık, İshak et al. “B12 Vitamini eksikliği Olan çocuklarda Helicobacter Pylori sıklığının araştırılması”. Çağdaş Tıp Dergisi 5/4 (February 2016), 221-225. https://doi.org/10.16899/ctd.77646.
JAMA Işık İ, Erdur C, Bozkurt Obuz U, Arslan N. B12 vitamini eksikliği olan çocuklarda Helicobacter pylori sıklığının araştırılması. J Contemp Med. 2016;5:221–225.
MLA Işık, İshak et al. “B12 Vitamini eksikliği Olan çocuklarda Helicobacter Pylori sıklığının araştırılması”. Çağdaş Tıp Dergisi, vol. 5, no. 4, 2016, pp. 221-5, doi:10.16899/ctd.77646.
Vancouver Işık İ, Erdur C, Bozkurt Obuz U, Arslan N. B12 vitamini eksikliği olan çocuklarda Helicobacter pylori sıklığının araştırılması. J Contemp Med. 2016;5(4):221-5.