Low plasminogen activator inhibitor-1 levels in thyroid carcinoma: uPA/PAI-1 paradox in cancer proggression

Year 2017, Volume: 7 Issue: 2, 120 - 125, 26.05.2017

Bekir Ucan , Muhammed Kizilgul , Mustafa Sahin , Mustafa Ozbek Seyda Ozdemir Erman Cakal

https://doi.org/10.16899/gopctd.316172

Abstract

Aim: Plasminogen activator inhibitor-1 (PAI-1) potently inhibits cell migration and apoptosis. Increased levels of PAI-1 were demonstrated in a great variety of cancers. Many studies demonstrated increased expression of PAI-1 in thyroid cancer and its relation to unfavorable clinical outcome. In this study, we aimed to investigate serum PAI-1 levels in patients with papillary thyroid carcinoma (PTC) as well as its effect in development and size of PTC.

Material and methods: Fifty-four papillary thyroid cancer patients (7 male, 47 female) and 24 healthy controls (6 male, 18 female) were enrolled in the study. Groups were compared by demographic, anthropometric, biochemical data, and by serum ghrelin levels. Serum PAI-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).

Results: Mean age were similar between PTC and control group (42.4 ± 10.1 to 42.5 ± 8.9, p:0.794). Serum PAI-1 levels were lower in patients with PTC when compared to healthy controls (241.34 ± 107.82 to 327.24 ± 138.51, p:0.011). BMI, Homa-IR and TSH, FT4, anti-TPO, anti-Tg, total cholesterol, triglyceride, HDL-Cholesterol, LDL-Cholesterol, calcium, phosphorus, 25-OH-VitD, parathormone, glucose, insülin concentrations were similar between groups (p>0.05). PAI-1 concentrations were not correlated with clinical, biochemical and hormonal parameters except parathormone (PTH) concentrations in PTC group (r:-0.446, p:0.0027).

Conclusions: Serum PAI-1 levels were lower in patients with papillary thyroid carcinoma. Our results might support the thesis of PAI-1 is expected to suppress cancer progression due to its ability to inhibit urokinase plasminogen activator activity.

Keywords

Plasminogen activator inhibitor-1, papillary thyroid carcinoma, urokinase plasminogen activator

Tiroid kanserinde düşük plazminojen aktivatör inhibitör-1 düzeyleri: Kanser gelişiminde uPA/PAI-1 paradoksu

Abstract

Amaç: Plazminojen aktivatör inhibitor-1 (PAI-1) hücre migrasyon ve apoptozisinin güçlü inhibitörüdür. Çoğu kanser türünde yüksek PAI-1 düzeyleri tespit edilmiştir. Bir çok çalışmada tiroid kanserlerinde artmış PAI-1 ekspresyonu ve bunun kötü klinik sonuçlarla ilişkili olduğu gösterilmiştir. Bu çalışmada papiller tiroid kanserlerinde(PTK) serum PAI-1 düzeylerini ve bunun PTK gelişimi ve boyutu üzerine etkisini araştırmak amaçlanmıştır.

Materyal ve Metod: Elli dört papiller tiroid kanser hastası (7 erkek, 47 kadın) ve 24 sağlıklı kontrol (6 erkek, 18 kadın) çalışmaya dahil edilmiştir.  Gruplar dermografik, antropometrik ve biyokimyasal veriler ile serum PAI-1 düzeyleri açısından  karşılaştırılmıştır. Serum PAI-1 düzeyleri enzim-bağlı immünabsorban kit (ELİZA) ile çalışılmıştır.

Results: Ortalama yaş PTK ve kontrol grubunda benzerdi (42.4 ± 10.1 ile 42.5 ± 8.9, p:0.794). Serum PAI-1 düzeyleri sağlıklı kontrollerle karşılaştırıldığında PTK hastalarında düşük olarak saptandı (241.34 ± 107.82 ile 327.24 ± 138.51, p:0.011). Vücut kitle indeksi (VKİ), Homa-IR, TSH, sT4, anti-TPO, anti-Tg, total kolesterol, trigliserid, HDL-kolesterol, LDL-kolesterol, kalsiyum, fosfor, 25-OH-VitD, parathormon, glukoz, insülin düzeyleri gruplar arasında benzer olarak bulundu (p>0.05). PTK hastalarında PAI-1 düzeyleri ile parathormon(PTH) dışında klinik, biyokimyasal ve hormonal parametreler arasında korelasyon bulunamadı (r:-0.446, p:0.0027).

Conclusions: Papiller tiroid kanserli hastalarda serum PAI-1 düzeyleri düşük olarak bulunmuştur. Bizim sonuçlarımız ürokinaz plazminojen aktivatör aktivitesini inhibisyon kapasitesinden dolayı kanser ilerlemesini baskılaması beklentisi tezini destekleyebilir.

Keywords

papiller tiroid kanseri, ürokinaz plazminojen aktivatörü, Plazminojen aktivatör inhibitor-1

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