Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma

Bahar Çuhacı Çakır; Ceyda Tuna Kırsaçlıoğlu; Emine Kaygı Tartıcı; Fatma Demirel

doi:10.16899/gopctd.317677

Research Article

Transient hyperphosphatasemia in infants and children: a retrospective study of 43 cases

Year 2017, Volume: 7 Issue: 2, 138 - 142, 31.05.2017

Bahar Çuhacı Çakır , Ceyda Tuna Kırsaçlıoğlu , Emine Kaygı Tartıcı Fatma Demirel

https://doi.org/10.16899/gopctd.317677

Abstract

Objective: To describe the prevalence and clinical characteristics of elevated plasma ALP levels during a period of 3 years at our clinic.

Material and Methods: We reviewed 533 children, retrospectively, to investigate the frequency, seasonal fluctuation, age distribution, and sex differences of the patients with the elevated ALP levels in younger than 5 years old children.

Results: Twenty-four of the patients were girls (55.8%), and the mean age of the patients was 7.48±12.77 (1-60) months. The mean serum alkaline phosphatase (ALP) level was 1402.23 ± 440.4 U/L (1038-3135 U/L) and it was 3.33±1.04 (2.47-7.46) fold above upper range. Their ALP levels returned to normal in a mean period of 2.5 ± 1.1 (1 to 5) months.

Conclusion: Early recognition of this benign entity, should help to avoid unnecessary tests.

Keywords

hyperphosphatasemia, infancy, children

References

1. Tolaymat N, de Melo MC. Benign transient hyperphosphatasemia of infancy and childhood. South Med J 2000; 93: 1162-64.
2. Behúlová D, Bzdúch V, Holesová D, et al. Transient hyperphosphatasemia of infancy and childhood: study of 194 cases. Clin Chem 2000; 46: 1868-69.
3. Kraut JR, Metrick M, Maxwell NR, et al: Isoenzyme studies in transient hyperphosphatasemia of infancy. ten new cases and a review of the literature. Am J Dis Child 1985; 139:736-740
4. Huh SY, Feldman HA, et al. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009; 124: 703-9.
5. Teitelbaum JE, Laskowski A, Barrows FP. Benign transient hyperphosphatasemia in infants and children: a prospective cohort. J Pediatr Endocrinol Metab 2011; 24: 351-3.
6. Carroll AJ, Coakley JC. Transient hyperphosphatasaemia: an important condition to recognize. J Paediatr Child Health 2001; 37: 359-62.
7. Otero JL, González-Peralta RP, Andres JM, et al. Elevated alkaline phosphatase in children: An algorithm to determine when a "Wait and See" approach is optimal. Clin Med Insights Pediatr 2011; 5: 15-8.
8. Gualco G, Lava SA, Garzoni L, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr 2013; 57: 167-71.
9. Lo SF. Reference Intervals for Laboratory Tests and Procedures. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics, 19th ed. Philadelphia: WB Saunders, 2011: 2466.
10. Kutilek S, Cervickova B, Bebova P, et al. Normal bone turnover in transient hyperphosphatasemia. J Clin Res Pediatr Endocrinol 2012; 4: 154-6.
11. Stein P, Rosalki SB, Foo AY, et al. Transient hyperphosphatasemia of infancy and early childhood: clinical and biochemical features of 21 cases and literature review. Clin Chem 1987; 33: 313-8.
12. Eymann A, Cacchiarelli N, Alonso G, et al. Benign transient hyperphosphatasemia of infancy. A common benign scenario, a big concern for a pediatrician. J Pediatr Endocrinol Metab 2010; 23: 927-30.
13. Turan S, Topcu B, Gökçe İ, et al. Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets. J Clin Res Pediatr Endocrinol 2011; 3: 7-11.
14. Suzuki M, Okazaki T, Nagai T, et al. Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol 2002; 33: 215-8.

Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma

Year 2017, Volume: 7 Issue: 2, 138 - 142, 31.05.2017

Bahar Çuhacı Çakır , Ceyda Tuna Kırsaçlıoğlu , Emine Kaygı Tartıcı Fatma Demirel

https://doi.org/10.16899/gopctd.317677

Abstract

Amaç: Kliniğimizde 3 yıllık bir süre boyunca yüksek plazma ALP düzeylerinin prevalansını ve klinik özelliklerini tanımlamak.

Gereç ve Yöntem: artmış ALP düzeyleri olan 5 yaşın altındaki 533 çocuğunu geriye dönük olarak taradık ve frekans, mevsimsel dalgalanma, yaş dağılımı ve cinsiyet farklılıklarını araştırdık.

Bulgular: Yirmi dört hasta (% 55.8) kızdı ve yaş ortalaması 7.48 ± 12.77 (1-60) ay idi. Ortalama alkalin fosfataz (ALP) düzeyi 1402.23 ± 440.4 U / L (1038-3135 U / L) ve üst aralıktan 3.33 ± 1.04 (2.47-7.46) kat daha yüksekti. ALP seviyeleri, ortalama 2.5 ± 1.1 (1-5) aylık bir süre içinde normale döndü.

Sonuç: Bu iyi huylu antitenin erken tanınması, gereksiz testlerden kaçınmaya yardımcı ollabilir

Keywords

hiperfosfatazemi, bebeklik, çocuklar

References

1. Tolaymat N, de Melo MC. Benign transient hyperphosphatasemia of infancy and childhood. South Med J 2000; 93: 1162-64.
2. Behúlová D, Bzdúch V, Holesová D, et al. Transient hyperphosphatasemia of infancy and childhood: study of 194 cases. Clin Chem 2000; 46: 1868-69.
3. Kraut JR, Metrick M, Maxwell NR, et al: Isoenzyme studies in transient hyperphosphatasemia of infancy. ten new cases and a review of the literature. Am J Dis Child 1985; 139:736-740
4. Huh SY, Feldman HA, et al. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009; 124: 703-9.
5. Teitelbaum JE, Laskowski A, Barrows FP. Benign transient hyperphosphatasemia in infants and children: a prospective cohort. J Pediatr Endocrinol Metab 2011; 24: 351-3.
6. Carroll AJ, Coakley JC. Transient hyperphosphatasaemia: an important condition to recognize. J Paediatr Child Health 2001; 37: 359-62.
7. Otero JL, González-Peralta RP, Andres JM, et al. Elevated alkaline phosphatase in children: An algorithm to determine when a "Wait and See" approach is optimal. Clin Med Insights Pediatr 2011; 5: 15-8.
8. Gualco G, Lava SA, Garzoni L, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr 2013; 57: 167-71.
9. Lo SF. Reference Intervals for Laboratory Tests and Procedures. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics, 19th ed. Philadelphia: WB Saunders, 2011: 2466.
10. Kutilek S, Cervickova B, Bebova P, et al. Normal bone turnover in transient hyperphosphatasemia. J Clin Res Pediatr Endocrinol 2012; 4: 154-6.
11. Stein P, Rosalki SB, Foo AY, et al. Transient hyperphosphatasemia of infancy and early childhood: clinical and biochemical features of 21 cases and literature review. Clin Chem 1987; 33: 313-8.
12. Eymann A, Cacchiarelli N, Alonso G, et al. Benign transient hyperphosphatasemia of infancy. A common benign scenario, a big concern for a pediatrician. J Pediatr Endocrinol Metab 2010; 23: 927-30.
13. Turan S, Topcu B, Gökçe İ, et al. Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets. J Clin Res Pediatr Endocrinol 2011; 3: 7-11.
14. Suzuki M, Okazaki T, Nagai T, et al. Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol 2002; 33: 215-8.

There are 14 citations in total.

Details

Subjects	Health Care Administration
Journal Section	Original Research
Authors	Bahar Çuhacı Çakır Ceyda Tuna Kırsaçlıoğlu Emine Kaygı Tartıcı This is me Fatma Demirel This is me
Publication Date	May 31, 2017
Acceptance Date	April 22, 2017
Published in Issue	Year 2017 Volume: 7 Issue: 2

Cite

APA	Çuhacı Çakır, B., Tuna Kırsaçlıoğlu, C., Tartıcı, E. K., Demirel, F. (2017). Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma. Çağdaş Tıp Dergisi, 7(2), 138-142. https://doi.org/10.16899/gopctd.317677
AMA	Çuhacı Çakır B, Tuna Kırsaçlıoğlu C, Tartıcı EK, Demirel F. Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma. J Contemp Med. June 2017;7(2):138-142. doi:10.16899/gopctd.317677
Chicago	Çuhacı Çakır, Bahar, Ceyda Tuna Kırsaçlıoğlu, Emine Kaygı Tartıcı, and Fatma Demirel. “Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma”. Çağdaş Tıp Dergisi 7, no. 2 (June 2017): 138-42. https://doi.org/10.16899/gopctd.317677.
EndNote	Çuhacı Çakır B, Tuna Kırsaçlıoğlu C, Tartıcı EK, Demirel F (June 1, 2017) Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma. Çağdaş Tıp Dergisi 7 2 138–142.
IEEE	B. Çuhacı Çakır, C. Tuna Kırsaçlıoğlu, E. K. Tartıcı, and F. Demirel, “Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma”, J Contemp Med, vol. 7, no. 2, pp. 138–142, 2017, doi: 10.16899/gopctd.317677.
ISNAD	Çuhacı Çakır, Bahar et al. “Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma”. Çağdaş Tıp Dergisi 7/2 (June 2017), 138-142. https://doi.org/10.16899/gopctd.317677.
JAMA	Çuhacı Çakır B, Tuna Kırsaçlıoğlu C, Tartıcı EK, Demirel F. Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma. J Contemp Med. 2017;7:138–142.
MLA	Çuhacı Çakır, Bahar et al. “Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma”. Çağdaş Tıp Dergisi, vol. 7, no. 2, 2017, pp. 138-42, doi:10.16899/gopctd.317677.
Vancouver	Çuhacı Çakır B, Tuna Kırsaçlıoğlu C, Tartıcı EK, Demirel F. Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma. J Contemp Med. 2017;7(2):138-42.