The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Year 2019, Volume: 9 Issue: 1, 9 - 14, 27.03.2019

Davut Bozkaya , Ebru Ergenekon Aysegul Yucel Sengul Ozdek İbrahim Hirfanoglu Ozden Turan , Canan Turkyilmaz Esra Onal Esin Koc , Yıldız Atalay

https://doi.org/10.16899/gopctd.535602

Abstract

Introduction:
Most important factors in retinopathy of prematurity (ROP) are prematurity and
oxygen toxicity although blood transfusions, insulin like growth factor-1 (
IGF-1), insulin like growth factor binding protein 3 (IGFBP-3) and vascular
endothelial growth factor (VEGF) also have important roles.

The
objectives of this study were, to measure IGF-1 and IGFBP-3 levels in preterm
newborns before and after blood transfusion and assess if the effect of
transfusion in development of ROP is via these mediators, and to investigate
whether IGF-1 and IGFBP-3 levels measured at 32 and 33 gestational age (GA)
were different in preterm newborns with and without ROP.

Material
and Methods: Preterm newborns with gestational age ≤34 weeks were included and
blood samples were obtained before and after red blood cell (RBC) transfusion.

Results:
Thirty newborns were included, 17 of whom had ROP ( stage 1: n=11, stage 2:
n=5, stage 3: n=1). IGF-1 and IGFBP-3 levels did not change after RBC
tranfusion. Excluding the patient with stage 3 ROP all ROP patients were
referred as mild ROP. No difference was observed between IGF-1 and IGFBP-3
levels of the patients with and without mild ROP. Patients with mild ROP had
significantly more number of transfusions.

Conclusions:
Erythrocyte transfusion increased the frequency of ROP, whereas IGFBP-3 and
IGF-1 were not associated of ROP.

Keywords

Retinopathy of prematurity, IGF-1, IGFBP-3

References

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