Development of a Controlled Released System Based on IPN Types Hydrogel for Cartilage Repair

Year 2024, , 576 - 591, 01.06.2024

Evrim Sever , Mehlika Pulat

https://doi.org/10.35378/gujs.1295326

Abstract

The purpose of this study is to develop a controlled Fluconazole and Naproxen releasing system for cartilage repair. Interpenetrating polymer network (IPN) type of hydrogels were prepared by using different ratios of 2-Hydroxyethyl methacrylate (HEMA) and gelatin. The hydrogels were synthesized by using ammonium persulfate (APS) and sodium metabisulfite (SBS) as initiator pair and ethylene glycol dimethacrylate (EGDMA) and glutaraldehyde (GA) as cross linkers. The prepared hydrogels were characterized via hydrogel formation and swelling/degradation measurements, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscope (SEM) analysis. From swelling tests, it is observed that semi-IPN hydrogels swell much more than full-IPNs which crosslinked by two agents, EGDMA and GA. The higher ratios of HEMA/gelatin negatively affect swelling values. In general, the IPN hydrogel discs were not affected by the variation of temperature. The release studies of Fluconazole and Naproxen were performed at 37 ⁰C and it is found that the swelling and releasing profiles were similar to each other. The releases of drugs increase rapidly at first and then complies nearly 36 h-48 h. Because of the looser and porous structure, semi-IPN hydrogels have higher release values than full-IPNs.

Keywords

Hydrogel, Gelatin, Cartilage, 2-Hydroxyethyl methacrylate, Controlled drug release

Supporting Institution

Gazi Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

FDK-6920

Thanks

The financial and technical support of the research from Gazi University Scientific Research Projects Unit (Project Code: FDK-2021-6920).

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