Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Year 2018, Volume: 31 Issue: 2, 399 - 406, 01.06.2018

Fatma Gökçe Apaydın , Kaan Kaltalıoğlu , Barbaros Balabanlı , Şule Coskun Cevher

Abstract

In this study, we investigated that the histopathological
changes of rat kidney and liver tissues after cisplatin administration and potential
beneficial effects of morin and hesperidin administration. Wistar rats were
randomly divided in 7 groups: control, morin (M), hesperidin (H), cisplatin
(CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H), cisplatin+morin+hesperidin
(CP+M+H). Kidney and liver tissues were collected at the end of the experiment
and were evaluated histopathological changes. Various histopathological changes
in kidney and liver tissues of cisplatin-induced group were revealed. However, pre-
and co-treatment of morin and/or hesperidin partially prevented these
hepatotoxic and nephrotoxic changes in cisplatin-induced groups.

Keywords

Cisplatin, Hepatotoxicity, Hesperidin, Histopathology, Morin

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