Synthesis of Some Novel Isoxazolidine Derivatives via 1,3-Dipolar Cycloaddition and Their Biological Evaluation

Year 2019, Volume: 32 Issue: 1, 78 - 89, 01.03.2019

Volkan Yanmaz Ali Dıslı , Serkan Yavuz , Hatice Ogutcu , Gulay Dılek

Abstract

A series of novel substituted isoxazolidine
derivatives were synthesized by 1,3-dipolar cycloaddition reaction. The
structures of the synthesized compounds were characterized using spectroscopic
methods. All the synthesized compounds were screened for their antibacterial
activities against Gram-positive and Gram-negative bacteria and for their
antifungal activities against a yeast strain. The results show that all the
synthesized compounds displayed significant activity against S. epidermis, M. luteus, B. cereus, B. abortus and C. albicans when compared to standard drugs. 

Keywords

Isoxazolidine, Nitrone, 1-3 Dipolar cycloaddition reaction, Antimicrobial activity

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