A speedy method for simultaneous determination in tablet active content by NIR and UV-Vis spectrophotometry: Comparison of PLS-1 and ICA-ANN models

Year 2021, Volume: 34 Issue: 2, 370 - 379, 01.06.2021

Ahmet Hakan Aktaş , Halil Orhun Şahin

https://doi.org/10.35378/gujs.752042

Abstract

In this study, the NIR and UV-Vis spectroscopy methods, which are frequently used in pharmaceutical industry, were applied to the environments where Paracetamol, Propyphenazone and Caffeine active substances are present, and the spectroscopic data obtained were evaluated comparatively with ICA-ANN and PLS-1, which are powerful chemometric methods. When using solid agents in NIR method, liquid solutions equivalent to them were used in UV-Vis method. Following the application of both methods, spectral data were evaluated as chemometrics and in both spectroscopic methods ICA-ANN method yielded more accurate results than PLS-1. High recovery rates and relatively low standard deviations were found in the applied methods and recommended for use in the pharmaceutical industry.

Keywords

Paracetamol, Caffeine, Propyphenazone, ICA -ANN

Supporting Institution

Süleyman Demirel Üniversitesi, BAP

Project Number

4626-YL1-16.

Thanks

The authors would like to thanks Süleyman Demirel University Scientific Research Project 4626-YL1-16.

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