Lead Nitrate Induced Oxidative Stress in Brain Tissues of Rats: Protective Effect of Sodium Selenite

Year 2014, Volume: 27 Issue: 3, 883 - 889, 28.04.2014

Suna Kalender , Fatma Apaydın Filiz Demir Hatice Baş

Abstract

Lead used in many industrial applications and it has been recognized as a toxic metal. The aim of this study is to investigate the effects of lead nitrate on brain tissues of diabetic and non-diabetic rats and the protective role of sodium selenite. Four weeks later, changes in antioxidant enzyme activities and MDA levels determined in the brain tissues. At the end of the study, we showed that lead nitrate causes oxidative stress in diabetic and non-diabetic rat brain and the sodium selenite can ameliorate this toxicity, but not protect completely.

Keywords

Lead Nitrate, Sodium selenite, Antioxidant Enzymes, Oxidative stress, Brain

References

• Al-Attar, A.M., “Vitamin E attenuates liver injury induced by exposure to lead, mercury, cadmium and copper in albino mice”, Saudi J. Biol. Sci. 18: 395-401 (2011).
• Pan, T., Wang, P., Al-Suwayeh, S.A., Chen, C., Fang, Y., “Skin toxicology of lead species evaluated by their
• comparison of organic and inorganic lead”, Toxicology Lett. 197: 19–28 (2010). proteomic profiles:
• A Narayana, K., Al-Bader, M., “Ultrastructural and DNA damaging effects of lead nitrate in the liver”, Exp. Toxicol. Pathol. 63: 43-51 (2011).
• Suematsu, N., Hosoda, M., Fujimori, K., “Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells”, Neurosci. Lett. 504: 223-227 (2011).
• Aydın, M., Çelik, S., “Effects of lycopene on plasma glucose, insulin levels, oxidative stress, and body weights of streptozotocin-induced diabetic rats”, Turk J. Med. Sci. 42: 1406-1413 (2012).
• Kalender, S., Uzun, F.G., Demir, F., Uzunhisarcıklı, M.,
• testicular toxicity in rats and the protective role of sodium selenite and vitamin E”, Food Chem. Toxicol. 55: 456-462 (2013).
• chloride-induced [7] Bhutada, P., Mundhada, Y., Bansod, K., Bhutada, C., Tawari, S., Dixit, P., Mundhada, D., “Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced
• Learn. Mem. 94: 293-302 (2010). rats”, Neurobiol. and antioxidant defense under
• lead [12] Schmatz, R., Mazzanti, C.M., Spanevello, R., Stefanello, N., Gutierres, J., Corrêa, M., Melgarejo da Rosa, M., Rubin, M.A., Schetinger, M.R.C., Morsch, V.M., “Resveratrol prevents memory deficits and the increase
• streptozotocin-induced
• Pharmacol. 610: 42-48 (2009). activity in J. diabetic rats”, Eur.
• Ohkawa, H., Ohishi, N., Yagi, K., “Assay for lipid peroxides in animal tissues by thiobarbituric acid rection”, Anal. Biochem, 95: 351-358 (1979).
• Marklund, S., Marklund, G., “Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase”, Eur. J. Biochem. 47: 469-474 (1974).
• Aebi, H., “Catalase in vitro”, Method Enzymol. 105: 121-126 (1984).
• Paglia, D.E., Valentine, W.N., “Studies on the quantative
• glutathione peroxidase”, J. Labor. Med. 70: 158-165 (1987). characterization
• of Habig, W.H., Pabst, M.J., Jakoby, W.B., “Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation”, J. Biol. Chem. 249: 7130- 7139 (1974).
• Pande, M., Flora, S.J.S., “Lead induced oxidative damage and its response to combined administration of α-lipoic acid and succimers in rats”, Toxicology 177: 187-196 (2002).
• Kojima, M., Masui, T., Nemoto, K., Degawa, M., “Lead
• hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis”, Toxicology Lett. 154: 35-44 (2004).
• Dana Devi, K., Saleha Banu, B., Grover, P., Jamil, K., “Genotoxic effect of lead nitrate on mice using SCGE (comet assay)”, Toxicology 145: 195-201 (2000).
• Abdallah, G.M., El-Sayed, E.S.M., Abo-Salem, O.M., “Effect of lead toxicity on coenzyme Q levels in rat tissues” Food Chem. Toxicol. 48: 1753-1756 (2010).
• Isik, I., Celik, I., “Acute effects of methyl parathion and diazinon as inducers for oxidative stress on certain biomarkers in various tissues of rainbowtrout (Oncorhynchus mykiss)”, Pestic. Biochem. Physiol. 92: 38-42 (2008).
• Durak, D., Kalender, S., Uzun, F.G., Demir, F., Kalender, Y., “Mercury chloride-induced oxidative stress and the protective effect of vitamins C and E in human erythrocytes in vitro”, Afr. J. Biotechnol. 9(4): 488-495 (2010).
• Khalaf, A.A., Moselhy, W.A., Abdel-Hamed, M.I., “The protective effect of green tea extract on lead induced oxidative and DNA damage on rat brain”, NeuroToxicology 33: 280-289 (2012).
• Antonio-García, M., Massó-Gonzalez, E.L., “Toxic effects of perinatal lead exposure on the brain of rats: Involvement of oxidative stress and the beneficial role of antioxidants”, Food Chem.Toxicol. 46: 2089-2095 (2008). [26]
• Marchlewicz, M., Marchetti, C., Kurzawski, M., Dziedziejko, V., Kolasa, A., Olszewska, M., Rybicka, M., Safranow, K., Nowacki, P., Wiszniewska, B., Chlubek, D., “Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead”, Brain Res. 1435: 56-71 (2012).
• I., Mansour, S.A., Mossa, A.H., “Lipid peroxidation and oxidative stress in rat erythrocytes induced by chlorpyrifos and the protective effect of zinc”, Pestic. Biochem. Physiol. 93: 34-39 (2009).
• Aly, H.A.A., Domènech, O., Banjar, Z.M., “Effect of nonylphenol on male reproduction: Analysis of rat epididymal biochemical markers and antioxidant defense enzymes”, Toxicol. Appl. Pharmacol. 261: 134-141 (2012).
• Jaya Prasanthi, R.P., Bhuvaneswari Devi, C., Chand Basha, D., Saya Reddy, N., Rajarami Reddy, G., “Calcium and zinc supplementation protects lead (Pb)- induced perturbations in antioxidant enzymes and lipid peroxidation in developing mouse brain”, Int. J. Devl Neurosci. 28: 161-167 (2010).
• Uzun, F.G., Kalender, Y., “Chlorpyrifos induced hepatotoxicity in rats and the protective role of quercetin and catechin”, Food Chem.Toxicol. 55: 549- 556 (2013).
• Demir, F., Uzun, F.G., Durak, D., Kalender, Y., “Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin”, Pestic. Biochem. Phys. 99: 77-81 (2011).
• Yavuz, O., Cam, M., Bukan, N., Guven, A., Silan, F., “Protective effect of melatonin on β-cell damage in streptozotocin-induced
• Histochem. 105: 261-266. (2003). in rats”,
• Acta [33] Cho, S.Y., Park, J.Y., Park, E.M., Choi, M.S., Lee, M.K., Jeon, S.M., Jang, M.K., Kim, M.J., Park, Y.B., “Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract” Clin. Chem. Acta, 317: 109-117 (2002).
• Baydas, G., Canatan, H., Turkoglu, A., “Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus”, J. Pineal Res. 32: 225-230 (2002).
• Shanmugam, K.R., Mallikarjuna, K., Nishanth, K., Kuo, C.H., Reddy, K.S., “Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues”, Food Chem. 124: 1436-1442 (2011).
• Suresh, S., Prithiviraj, E., Lakshmi, N.V., Ganesh, M.K., Ganesh, L., Prakash, S., “Effect of Mucuna pruriens (Linn.) on mitochondrial dysfunction and DNA damage in epididymal sperm of streptozotocin induced diabetic rat”, J. Ethnopharmacol. 145: 32-41 (2013).
• Orun, I., Selamoglu Talas, Z., Ozdemir, I., Alkan, A., Erdogan, K., “Antioxidative role of selenium on some tissues of (Cd2+, Cr3+)-induced rainbow trout”, Ecotox. Environ. Safe. 71: 71-75 (2008).
• El-Demerdash, F.M., “Effects of selenium and mercury on the enzymatıc activities and lipid peroxidation in Brain, liver, and blood of rats”, J. Environ. Sci. Health, B36(4): 489-499 (2001).
• Grosicki, A., Kowalski, B., “Lead, cadmium and mercury influence on selenium fate in rats”, Bull. Vet. Inst. Pulawy 46: 337-343 (2002).