Assessment of Some Biochemistry Parameters in Hospitalized Patients Evaluated with CT and RT-PCR for The Diagnosis of Covid-19

Year 2022, Volume: 11 Issue: 1, 95 - 104, 19.03.2022

Ayşegül Sümer , Lütfiye Nur Uzun

Abstract

Aralık 2019’da Wuhan, Hubei Çin’de arda arda görülen pnömoni vakalarının sebebinin yeni bir tip koronovirus (2019-nCoV) olduğu bildirilmiştir. Bu çalışmada COVID-19 tanısı RT-PCR testi ile doğrulanmış veya BT görüntülemesinde buzlu cam alanları tespit edilmiş hastaların laboratuar bulgularının değerlendirilmesi amaçlanmıştır. Tek merkezli retrospektif olarak planlanan çalışmaya çeşitli dışlama kriterleri ile 51 kişi dahil edilmiştir. Karşılaştırma, RT-PCR testi yapılan, bilgisayarlı akciğer tomografisi yapılan ve sonuçlarına göre dört gruba ayrılan hastaların laboratuvar bulguları ölçülerek yapıldı. Tüm verilere elektronik sağlık kayıtları aracılığıyla erişildi. İstatistiksel analiz yöntemi olarak yüzde ve frekanslara ek olarak Fisher Exact Test, Tek Yönlü ANOVA, Kruskall Wallis Testi, post-hoc düzeltilmiş Bonferonni testi kullanıldı. Laboratuvar bulgularında WBC, NEU, EOS, Protrombin zamanı, INR ve Troponin seviyelerinde COVID-19 lehine önemli veriler elde edildi. Hastanın kliniğe kabulünde laboratuvar bulgularının ön tanı olarak kullanılabileceği, ayrıca hastalığın klinik şiddetini belirlemeye ve prognozu öngörmeye yardımcı olabileceği sonucuna varıldı.

Keywords

covid 19, Klinik özellikler, laboratuvar bulguları

Assessment of Some Biochemistry Parameters in Hospitalized Patients Evaluated with CT and RT-PCR for The Diagnosis of Covid-19

Abstract

It was reported that a new type of coronavirus (2019-nCoV) was the cause of repeated pneumonia cases in Wuhan, Hubei Province, China in December 2019. The aim of this study was to evaluate the laboratory results of the patients diagnosed with COVID-19 as confirmed by RT-PCR test or presence of ground-glass opacities on CT imaging. 51 people with various exclusion criteria were included in the single-center study planned retrospectively. Comparison was made by measuring the laboratory findings of the patients who underwent RT-PCR test, who underwent computed lung tomography and who were divided into four groups according to their results. All data were accessed via electronic health records. Fisher Exact Test, One Way ANOVA, Kruskall Wallis Test were used as statistical analysis method in addition to percentages and frequencies and adjusted Bonferonni test were used for post-hoc analysis. In laboratory findings, significant data were obtained in favor of COVID-19 at WBC, NEU, EOS, Prothrombin time, INR and Troponin levels. It was concluded that laboratory findings can be used as a preliminary diagnosis in the admission of the patient to the clinic, and also help to determine the clinical severity of the disease and predict the prognosis.

Keywords

covid 19, Clinical characteristics, Laboratory findings

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