Osteoporoz için Çeşitli İlaçlı Tedavi Seçeneklerinin Etkinliği Üzerine Bir Meta-analiz

Year 2023, Volume: 12 Issue: 3, 1131 - 1140, 26.09.2023

Nurmuhammet Taş

https://doi.org/10.37989/gumussagbil.1346550

Abstract

Bu meta-analizin amacı, osteoporoz için farklı tedavi seçeneklerini gözden geçirmek ve değerlendirmek, etkinliklerini incelemektir. Özellikle, osteoporoz tedavisinde D vitamini, bifosfonatlar, odanacatib, neridronat, teriparatid ve raloksifenin kullanımının tedavi sürecindeki etkinliği araştırılmaktadır. Bu amaçla mevcut araştırmaların harmanlanarak yorumlanmasına olanak sunan meta-analiz yöntemi kullanılmıştır. Çalışmaya 10 birincil çalışma dâhil edilmiştir. Çalışma, osteoporoz ilaçlarının serum phosphate, sCTX ve Serum 25(OH)D değerleri üzerindeki etkisini değerlendirmeyi amaçlamıştır. Bulgularımız, osteoporoz ilaçlarının bu parametreler üzerinde genel bir etkiye sahip olduğunu göstermektedir. Osteoporoz ilaçlarının birleştirilmiş etki büyüklüğü -1,53 (CI: -3,00 ila -0,07) olarak hesaplanmıştır. Serum phosphate, sCTX ve Serum 25(OH)D değerleri için ayrı ayrı yapılan analizlerde de bu ilaçların olumlu etkileri tespit edilmiştir.

Keywords

Bifosfonat, D Vitamini, Odanacatib, Osteoporoz tedavisi, Teriparatid

A Meta-analysis on the Efficacy of Various Medicated Treatment Options for Osteoporosis

Abstract

This meta-analysis aims to review and evaluate different osteoporosis treatment options and examine their efficacy. In particular, the effectiveness of vitamin D, bisphosphonates, odanacatib, neridronate, teriparatide, and raloxifene in the treatment of osteoporosis is investigated. For this purpose, the meta-analysis method, which allows the existing studies to be collated and interpreted, was used. Ten primary studies were included in the study. The study aimed to evaluate the effect of osteoporosis drugs on serum phosphate, sCTX, and serum 25(OH)D values. Our findings show that osteoporosis drugs have an overall effect on these parameters. The pooled effect size of osteoporosis drugs was calculated as-1.53 (CI: -3,00 to -0,07). Separate analyses for serum phosphate, sCTX, and serum 25(OH)D values also showed positive effects of these drugs.

Keywords

Bisphosphonate, Odanacatib, Osteoporosis treatment, Teriparatide, Vitamin D

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