Evaluation of Serum Biochemical Parameters Primarily Liver Functions in Smokers: A Case-control Study

Yıl 2024, Cilt: 13 Sayı: 3, 1125 - 1131, 26.09.2024

Yılmaz Sezgin , Sinan Becel , Abdurrahman Polat

https://doi.org/10.37989/gumussagbil.1460296

Cited By: 1

Öz

We investigated the effects of smoking on serum biochemical parameters primarily liver functions and metabolism.
This is a case-control study. The case and control groups were formed by clinical randomization by using the data obtained from the hospital information system and patient records, including age, gender, height, and weight. Smokers were identified as the case group, while non-smokers were identified as the control group. In the comparisons of rates Chi-square tests were used and in the comparisons of averages, independent sample t and MANCOVA tests were used.
When covariance factors such as age, gender, body mass index, and alcohol use were taken into consideration, it found that AST, ALT, and GGT were higher in smokers, whereas vitamin D, vitamin B12, and TSH were higher in non-smokers.
We found that smoking has a negative effect on liver and bile functions, and vitamin D values are affected secondary to this negative effect

Anahtar Kelimeler

Smoking tobacco, Biochemical parameters, Metabolism, Hepatotoxicity

Sigara İçenlerde Karaciğer Fonksiyonları Başta Olmak Üzere Serum Biyokimyasal Parametrelerinin Değerlendirilmesi: Bir Vaka-kontrol Çalışması

Öz

Sigaranın karaciğer fonksiyonları ve metabolizma başta olmak üzere serum biyokimyasal parametreleri üzerine etkilerini araştırdık.
Bu bir vaka kontrol çalışmasıdır. Olgu ve kontrol grupları hastane bilgi sistemi ve hasta kayıtlarından elde edilen yaş, cinsiyet, boy, kilo gibi veriler kullanılarak klinik randomizasyonla oluşturuldu. Sigara içenler vaka grubu, içmeyenler ise kontrol grubu olarak belirlendi. Oranların karşılaştırılmasında Ki-kare testi, ortalamaların karşılaştırılmasında ise bağımsız örneklem t ve MANCOVA testleri kullanıldı.
Yaş, cinsiyet, vücut kitle indeksi ve alkol kullanımı gibi kovaryans faktörleri dikkate alındığında sigara içenlerde AST, ALT ve GGT'nin, sigara içmeyenlerde ise D vitamini, B12 vitamini ve TSH'nin daha yüksek olduğu görüldü. .
Sigaranın karaciğer ve safra fonksiyonlarını olumsuz etkilediğini, bu olumsuz etkiye ikincil olarak D vitamini değerlerinin de etkilendiğini tespit ettik.

Anahtar Kelimeler

Sigara içmek, Biyokimyasal parametreler, Metabolizma, Hepatotoksisite

Etik Beyan

Etik Onay Belgesi eklenmiştir

Kaynakça

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