The Efficacy of Intraartricular Botulinum A Injection in the Treatment of Knee Osteoarthritis

Year 2017, Volume: 9 Issue: 2, 84 - 89, 01.06.2017

Bora Uzuner Alper Kurt Fatih Özkan

Abstract

Osteoarthritis (OA) is a progressive joint disease
that affects all structures, especially cartilage. Knee pain caused by OA has
been shown to be one of the most common causes of physical impairment in the
elderly. Recently, articles on intra-articular botulinum toxin (BTX) injection
in patients with no palliation of pain with conventional treatment methods have
been reported frequently. In this case, we aimed to discuss whether
intra-articular BTX-A injection affects in patient with knee OA in which we can
not achieve a sufficient palliation of pain with conventional treatment modalities.

Keywords

Knee, Osteoarthritis, treatment, Botulinum

Diz Osteoartriti Tedavisinde Eklem İçi Botilinum A Enjeksiyonunun Etkinliği

Abstract

Osteoartrit (OA), başta kıkırdak olmak üzere eklemi
oluşturan bütün yapıları etkileyen ilerleyici bir eklem hastalığıdır. Özellikle
OA bağlı diz ağrısı yaşlılarda görülen fiziksel yetersizliğin en sık
nedenlerinden biri olduğu çalışmalarda gösterilmiştir.Konvansiyonel tedavi
yöntemleri ile ağrı palyasyonu sağlanamayan hastalarda intra-artiküler
botulinum toksin (BTX)  enjeksiyonu ile
ilgili yayınlara son zamanlarda daha sık rastlanmaktadır.Bu olgu sunumunda
geleneksel tedavi yöntemleri ile yeterli ağrıda azalma sağlayamadığımız diz OA
tanılı hastada eklem içi BTX-A enjeksiyonunun etkilerini tartışmayı  hedefledik. 

Keywords

Diz, osteoartrit, tedavi, Botulinum

References

• 1. Kaçar C, Gilgil E, Urhan S, Arikan V, Dündar U, Oksüz MC, et al. The prevalence of symptomatic knee and distal interphalangeal joint osteoarthritis in the urban population of Antalya, Turkey. Rheumatol Int. 2005;25:201-4.
• 2. Frank A, Wollheim A. Osteoarthritis.Curr Opin Rheumatol. 2002; 14:571-572.
• 3. Brooks PM. Impact of osteoarthritis on individuals and society: how much disability? Social consequences and health economic implications. Curr Opin Rheumatol. 2002; 14(5):573-577.
• 4. Sycha T, Kranz G, Auff E, Schnider P. Botulinum toxin in the treatment of rare head and neck pain syndromes: a systematic review of the literature. J Neurol. 2004; 251 (Suppl1): I19-30
• 5. Nguyen C, Rannou F.The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review. Expert Opin Drug Saf.2017;16(8):897-902
• 6. 11. National Institutes of Health (N1H) Consensus Conference. Clinical use of botulinum toxin. Connecticut Medicine. 1991: 55:471-7.
• 7. Borodic GE, Cheney M, McKenna M. Controlateral injection of botulinum A toxin for the treatment of hemifacial spasm to achieve increased facial symmetry. PlastReconstr Surg. 1992;90:972-7.
• 8. Arezzo JC. Possible mechanisms for the effects of botulinum toxin on pain. Clin J Pain. 2002;18(6 Suppl.):S125–32
• 9. Boon AJ, Smith J, Dahm DL, Sorenson EJ, Larson DR, Fitz-Gibbon PD, et al. Efficacy of intra-articular botulinum toxin type A in painful knee osteoarthritis: a pilot study. PMR. 2010;2:268–76.
• 10. Mahowald ML, Singh JA, Dykstra D. Long term effects of intra-articular botulinum toxin A for refractory joint pain. Neurotox Res. 2006;9:179–88.