Metastatik kemik sarkomlu hastalarda albumin-alkalen fosfataz oranının sağ kalıma etkisi

Year 2024, Volume: 6 Issue: 1, 71 - 78, 26.02.2024

Emel Mutlu , Oktay Bozkurt , Mevlüde İnanç , Metin Ozkan , Sedat Tarık Fırat , Ramazan Coşar , İrfan Buğday , Muhammet Cengiz , Ahmet Kürşad Dişli , Murat Eser

https://doi.org/10.52827/hititmedj.1389249

Abstract

Amaç: Metastatik kemik sarkomu hastalarında albümin-alkalen fosfataz oranının (AALPO) sağ kalıma etkisini araştırmak.
Hasta ve Yöntem: Çalışmaya metastatik evrede olan 60 kemik sarkomu hastası dahil edildi. Kemoterapi öncesi bakılan AALPO ile genel sağkalım (GS) ve progresyonsuz sağkalım (PS) arasındaki ilişki Cox regresyonu multivariate analizi ile değerlendirildi.
Bulgular: Çalışmaya alınan hastaların 25 (%58.3)’i osteosarkom, 16 (%26.7)’si Ewing sarkomu, 5(%8.3)’ü kondrosarkom ve 4 (%6.7)’ü dev hücreli kemik tümörüydü. ROC analizi ile elde edilen AALPO değeri 0.039 olarak bulundu. AALPO ≥ 0,039 grubundaki medyan PS ve GS, <0,039 olan gruba göre istatistiksel olarak anlamlı derecede yüksekti (p=0.006, p=0.003). AALPO <0.039 (HR=1.778, %95 Cl, 1.211-1.912, p=0.023) olması düşük genel GS ile ilişkili ve (HR=4.782, %95 Cl, 1.963-11.647, p=0.001) olması düşük PS ile ilişkili bulundu.
Sonuç: Çalışmamızda metastatik kemik sarkomlu hastalarda kemoterapi öncesi düşük AALPO değeri, kötü GS ve PS ile ilişkili bulunmuştur. Daha önce birçok kanser türünde düşük AALPO kötü GS ve PS ile ilişkili bulunmuştur ancak daha önce kemik kanseri hastalarında AALPO’nun sağ kalım ile ilişkisi değerlendirilmemiştir. Çalışmamız literatürde bu konuyu araştıran ilk çalışmadır. AALPO, hastaların prognozunu değerlendirmede ucuz ve basit bir belirteç olarak kullanılabilir. Ancak daha kesin sonuçlar söylemek için daha fazla hasta sayısı ile yapılacak çalışmalara ihtiyaç vardır.

Keywords

kemik kanseri, osteosarkom, nötrofil lenfosit oranı, albumin alkalen fosfataz oranı

The effect of albumin to alkaline phosphatase ratio on survival in patients with metastatic bone sarcomas

Abstract

Objective: To investigate the effect of albumin to alkaline phosphatase ratio (AALPR) at survival in patients with metastatic bone sarcomas.
Patients and Methods: 60 patients with metastatic bone sarcomas were included in the study. The relationship between AALPR before chemotherapy and overal survival (OS) and progression free survival (PFS) was evaluated with Cox regression multivariate analysis.
Results: Of the patients in the study, 25 (58.3%) were osteosarcoma, 16 (26.7%) Ewing's sarcoma, 5 (8.3%) chondrosarcoma and 4 (6.7%) giant cell bone tumor. AALPR was 0.039 obtained in ROC analysis. The median PFS and OS at AALPR ≥ 0.039 group was statistically significantly higher than the group with <0.039 (p=0.006, p=0.003). AALPR <0.039 was found to be associated with poor OS and PFS (OS, HR=1.778, 95% CI, 1.211-1.912, p=0.023 - PFS, HR=4.782, 95% CI, 1.963-11,647, p=0.001 ).
Conclusion: In our study, low AALPR value before chemotherapy was associated with poor OS and PFS in patients with metastatic bone sarcoma. Low AALPR has been associated with poor OS and PFS in many cancer types, but the association of AALPR with survival at bone sarcoma patients has not been evaluated previously. Our study is the first in the literature to investigate this issue. AALPR can be used as an inexpensive and simple marker to evaluate the prognosis of patients. However, studies with larger number of patients are needed to give more precise results.

Keywords

Bone cancer, osteosarcoma, albumin to alkaline phosphatase ratio, neutrophil to lymphocyte ratio

Ethical Statement

The study was carried out with the permission of Erciyes University Medical Faculty Clinical Researches Ethics Committee (Date:28.09.2022 Decision No:2022/675).

Supporting Institution

The authors did not receive support from any organization for the submitted work.

Thanks

The authors did not receive support from any organization for the submitted work.

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