Fungal Biotransformation of Cedryl Formate

Year 2023, Volume: 51 Issue: 3, 283 - 287, 16.07.2023

Özge Özşen Batur , İsmail Kıran , Kemal Hüsnü Can Başer , Fatih Demirci

https://doi.org/10.15671/hjbc.1244894

Abstract

Cedryl formate is a synthetic fragrance compound, which is an ester derivative of the sesquiterpenoid cedrol, found in different parts of the cedar tree/cedarwood with a characteristic fragrance. Cedryl formate is used in cosmetics and personal care products like fragrances, perfumes, as well as in the chemical and agriculture industries in various forms. In the present work, the microbial transformation of the formate was evaluated by 13 fungal cultures to produce new derivatives. Among the evaluated, the plant pathogenic fungus Aspergillus niger NRRL 326, biotransformed to the metabolite 8-cedren-3β-ol derivative with 6.2% yield. The structure of the chromatographically purified metabolite was elucidated by NMR and spectroscopic methods.

Keywords

Aspergillus niger, Biotransformation, Cedrol, Fragrance compounds

Supporting Institution

Scientific and Technological Research Council of Turkey

Project Number

Grant no: 00530.STZ.2010-1

Thanks

The authors would like to thank to the Turkish Ministry of Science, Industry and Technology (Grant no: 00530.STZ.2010-1) for partial financial support. The authors would like to dedicate this work for the 75th birthday of Prof. Dr. Yoshiaki NOMA a master of biotransformations.

Sedril Formatın Mikrobiyal Dönüşümü

Abstract

Sedril format sedrol molekülünün sentetik esteri olan bir koku bileşiğidir. Sedrol sedir ağacının uçucu yağı dahil farklı bulunan bir seskiterpen aromatik bileşiktir. Sedirin karakteristik kokusunu vermektedir. Sedril format, parfüm ve kozmetik gibi kişisel bakım ürünleri ile kimya, ve hatta tarım endüstrisi gibi alanlarda kullanılmaktadır. Bu çalışmada format substratı farklı 13 fungal kültür ile türevlendirilmesi incelenmiştir. Sonuçlar arasında, bitki patojeni olan Aspergillus niger NRRL 326, substratı %6.2 verimle 8-cedren-3β-ol metabolitine biyolojik olarak ilk defa dönüştürülmüştür. Kromatografik yöntemlerle saflaştırılan metabolitin yapısı NMR ve spektroskopik metodlar kullanılarak aydınlatılmıştır.

Keywords

Aspergillus niger, Biyotransformasyon, Sedrol, Koku bileşikleri

Project Number

Grant no: 00530.STZ.2010-1

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