Reduction Behavior of Moxifloxacin Hydrocholaride and Its Analysis in Spiked Human Urine and Dosage Form by Voltammetry

Year 2019, , 153 - 156, 30.06.2019

Burcu Tepeli Selehattin Yilmaz Sultan Yagmur

https://doi.org/10.17350/HJSE19030000141

Cited By: 2

Abstract

A voltammetric method was developed to analyze moxifloxacin hydrochloride MoxHCl in pharmaceutical preparations and spiked human urine. The experimental measurements were completed using different buffer systems pH 0.50- 12.05 on Glassy Carbon Electrode GCE with differential pulse voltammetry DPV and Cyclic Voltammetry CV methods. The effect of pH on the peak current and potential were determined. Britton-Robinson BR buffer pH 7.00 was used for analysis. The peak was established to be diffusion-controlled based on the nature of electrode. Calibration plots were prepared for the concentration range from 3×10-4 M to 1.1×10-3 M with DPV. Limits of detection LOD and quantification LOQ were calculated as 5.1×10-5 M and 2.30×10-4 M, respectively. The validation of the applied methods was completed. Electroreduction mechanism was proposed

Keywords

Moxifloxacin hydrochloride, Reduction, Pharmaceutical Preparations, Human urine, Voltammetry.

References

• 1. Zhou Q, Long L, Liu L, Zhai H, Zhu M. Electrochemical determination of moxifloxacin hydrochloride based on molecularly imprinted polymer modified carbon paste electrode. Int. J. Electrochem. Sci. 10 (2015) 5069-5076.
• 2. Khan W, Sullivan KL, McCann JW, Gonsalves CF, Sato T. Moxifloxacin Prophylaxis for Chemoembolization or Embolization in Patients With Previous Biliary Interventions: A Pilot Study, AJR. Am J Roentgenol 197 (2011) 343-345.
• 3. Gyssens I.C, Dryden M, Kujath P, Nathwani D, Schaper N, Hampel B. J. Antimicrob Chemother 66 (2011) 2632-2642.
• 4. Xu YH, Li D, Liu XY, Li YZ, Lu J. Journal of Chromatography B 878 (2010) 3437-3341.
• 5. Hemanth A, Kumar K, Sudha V, Srinivasan R, Ramachandran G. Simple and rapid liquid chromatography method for determination of moxifloxacin in saliva. Journal of Chromatography B 879 (2011) 3663-3667.
• 6. Ulu S.T. Journal of Pharm. And Biomed. A. 43 (2007) 320-323.
• 7. Upadhyay SS, Kalambate PK, Srivastava AK. Enantioselective analysis of Moxifloxacin hydrochloride enantiomers with graphene-β-Cyclodextrin-nanocomposite modified carbon paste electrode using adsorptive stripping differential pulse voltammetry. Electrochimica Act. 248 (2017) 258-269.
• 8. Radi AE,Wahdan T, Anwar Z, Mostafa H. Electrochemical and spectroscopic studies on the Interaction of Gatifloxacin, Moxifloxacin and sparfloxacin with DNA and their analytical applications. Electroanalysis 22 (2010) 2665-2671.
• 9. Erk N. Voltammetric Behaviour And Determination Of Moxifloxacin In Pharmaceutical Products And Human Plasma. Anal Bioanal.Chem. 378 (2004) 1351-1356.
• 10. Long N, Zhu M, Yan Z. Anodic Adsorptive Voltammetric Determination of Moxifloxacin Hydrochloride. Physical Testing and Chemical Analysis (Part B: Chemical Analysis. R914;O657.14, 2012.
• 11. Trindade MAG, Da Silva GM, Ferreira VS. Interaction study of moxifloxacin with Cu(II) ion using square-wave voltammetry and its application in the determination in tablets. Microchemical Journal 81(2005) 209-216.
• 12. Abdel Ghani NT, El-Ries MA, El-Shall MA. Validated polarographic methods for the determination of certain antibacterial drugs. Analytical Sciences, 23 (2007) 1053-1058.
• 13. İnam R, Mercan H , Yılmaz E, Uslu B. Differential Pulse Polarographic Determination of Co(II) Using Moxifloxacine. Analytical Letters 40 (2007) 529-546.
• 14. Skrzypek S, Ciesielski W, Sokolowski A,Yılmaz S, Kazmiercak D. Square wave adsorptive stripping voltammetric determination of famotidine in urine. Talanta 66 (2005) 1146-1151.
• 15. Çıtak M,Yılmaz S, Dilgin Y,Türker G,Yağmur S, Erdugan H. Osteryoung Square Wave Voltammetric Determination of Phenazopyridine Hydrochloride in Human Urine and Tablet Dosage Forms Based on Electrochemical Reduction at Carbon Paste Electrode. Curr. Pharm. Anal. 3 (2007)141-145.
• 16. Yağmur S,Yılmaz S, Sadıkoğlu M, Saglıkoğlu G, Yıldız M, Yengin Ç, Kılınç E. Electrooxidation of Phenazopyridine Hydrochloride and its Voltammetric and HPLC Determination in Human Urine and Tablet Dosage Form. Int. J. Electrochem. Sci. 8 (2013) 6818-6828.