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Nadir Bir Olgu: Nikolay Sendromu

Year 2024, Volume: 4 Issue: 2, 70 - 73, 22.08.2024
https://doi.org/10.58961/hmj.1496765

Abstract

Nikolay Sendromu, ilk olarak sifiliz tedavisi için bismuth enjeksiyonu yapılan hastalarda gözlemlenmiştir. Çeşitli ilaçların enjeksiyonu sonrasında görülebilir. Enjeksiyon yerinde ağrı, ödem ve renk değişikliği ile ilerleyen bu durum, farkında olunmadığı ve zamanında uygun şekilde tedavi edilmediği takdirde hasta açısından geri dönüşümü olmayan ciddi sonuçlar doğurabilir. Olgumuzda diklofenak sodyumun intramuskuler kullanımının ardından görülmüştür. Nadir görülmesi ve farkındalığın artırılması için olgumuzu sunmak istedik.

References

  • Sasmal PK, Sahoo A, Singh PK, VS V. Nicolau Syndrome: An Unforeseen Yet Evadable Consequence of Intramuscular Injection. Surg J. 2021;07(02):e62–5.
  • Phiri W, Musonda MS, Kyakilika K, Miyoba MH, Malumani M. Nicolau syndrome following intramuscular benzathine penicillin injection: a case report. Pan Afr Med J. 2020;37(276):276.
  • Demircan C, Akdogan N, Elmas L. Nicolau Syndrome Secondary to Subcutaneous Glatiramer Acetate Injection. Int J Low Extrem Wounds. 2020;1–3.
  • Tabor D, Bertram CG, Williams AJK, Mathers ME, Biswas A. Nicolau Syndrome (Embolia Cutis Medicamentosa): A rare and poorly recognized iatrogenic cause of cutaneous thrombotic vasculopathy. Am J Dermatopathol. 2018;40(3):212–5.
  • Qureshi I, Pathan SA, Qureshi RS, Thomas SH. Intramuscular versus oral diclofenac for acute pain in adults with acute musculoskeletal injuries presenting to the ED setting: A prospective, double-blind, double-dummy, randomised controlled trial. Emerg Med J. 2019;36(7):401–6.
  • Moore N, Duong M, Gulmez SE, Blin P, Droz C. Pharmacoepidemiology of non-steroidal anti-inflammatory drugs. Therapie [Internet]. 2019;74(2):271–7. Available from: https://doi.org/10.1016/j.therap.2018.11.002
  • Probst M, Kühn J-P, Modeß C, Scheuch E, Seidlitz A, Hosten N, et al. Muscle Injury After Intramuscular Administration of Diclofenac: A Case Report Supported by Magnetic Resonance Imaging. Drug Saf - Case Reports. 2017;4(1):4–8.
  • Mishra P, Stringer MD. Sciatic nerve injury from intramuscular injection: A persistent and global problem. Int J Clin Pract. 2010;64(11):1573–9.
  • Aktas H, Yılmaz OE, Ertugrul G, Terzi E. Intramuscular diclofenac is a cause of Nicolau syndrome in obese women: An observational study of consecutive ten patients. Dermatol Ther. 2020;33(3):2–4.
  • Killedar RS, Gupta S, Shindhe P. Ayurveda management of Nicolau syndrome W.S.R to Kotha – a case report. J Ayurveda Integr Med [Internet]. 2021;12(1):165–8. Available from: https://doi.org/10.1016/j.jaim.2020.07.004
  • Bhanja DB, Sil A, Chakraborty S. Intramuscular diclofenac-induced iatrogenic cutaneous necrosis. Postgrad Med J. 2020;96(1135):298–9. Chen Z, Zhang B, Wu D et al. Characteristics of predominantly right-sided colonic diverticulitis without need for colectomy. BMC Surg. 2020 Sep 14;20(1):202.
  • Pavlidis ET, Pavlidis TE. Current aspects on the management of perforated acute diverticulitis: A narrative review. Cureus. 2022 Aug 26;14(8):e28446.

A Rare Case: Nicolau Syndrome

Year 2024, Volume: 4 Issue: 2, 70 - 73, 22.08.2024
https://doi.org/10.58961/hmj.1496765

Abstract

Nikolay Syndrome was first observed in patients who received bismuth injection for the treatment of syphilis. It can be seen after the injection of various drugs. This condition, which progresses with pain, edema and discoloration at the injection site, can have serious, irreversible consequences for the patient if not aware of it and not treated appropriately in a timely manner. In our case, it occurred after the intramuscular use of diclofenac sodium. We wanted to present our case so that is rare and raises awareness.

References

  • Sasmal PK, Sahoo A, Singh PK, VS V. Nicolau Syndrome: An Unforeseen Yet Evadable Consequence of Intramuscular Injection. Surg J. 2021;07(02):e62–5.
  • Phiri W, Musonda MS, Kyakilika K, Miyoba MH, Malumani M. Nicolau syndrome following intramuscular benzathine penicillin injection: a case report. Pan Afr Med J. 2020;37(276):276.
  • Demircan C, Akdogan N, Elmas L. Nicolau Syndrome Secondary to Subcutaneous Glatiramer Acetate Injection. Int J Low Extrem Wounds. 2020;1–3.
  • Tabor D, Bertram CG, Williams AJK, Mathers ME, Biswas A. Nicolau Syndrome (Embolia Cutis Medicamentosa): A rare and poorly recognized iatrogenic cause of cutaneous thrombotic vasculopathy. Am J Dermatopathol. 2018;40(3):212–5.
  • Qureshi I, Pathan SA, Qureshi RS, Thomas SH. Intramuscular versus oral diclofenac for acute pain in adults with acute musculoskeletal injuries presenting to the ED setting: A prospective, double-blind, double-dummy, randomised controlled trial. Emerg Med J. 2019;36(7):401–6.
  • Moore N, Duong M, Gulmez SE, Blin P, Droz C. Pharmacoepidemiology of non-steroidal anti-inflammatory drugs. Therapie [Internet]. 2019;74(2):271–7. Available from: https://doi.org/10.1016/j.therap.2018.11.002
  • Probst M, Kühn J-P, Modeß C, Scheuch E, Seidlitz A, Hosten N, et al. Muscle Injury After Intramuscular Administration of Diclofenac: A Case Report Supported by Magnetic Resonance Imaging. Drug Saf - Case Reports. 2017;4(1):4–8.
  • Mishra P, Stringer MD. Sciatic nerve injury from intramuscular injection: A persistent and global problem. Int J Clin Pract. 2010;64(11):1573–9.
  • Aktas H, Yılmaz OE, Ertugrul G, Terzi E. Intramuscular diclofenac is a cause of Nicolau syndrome in obese women: An observational study of consecutive ten patients. Dermatol Ther. 2020;33(3):2–4.
  • Killedar RS, Gupta S, Shindhe P. Ayurveda management of Nicolau syndrome W.S.R to Kotha – a case report. J Ayurveda Integr Med [Internet]. 2021;12(1):165–8. Available from: https://doi.org/10.1016/j.jaim.2020.07.004
  • Bhanja DB, Sil A, Chakraborty S. Intramuscular diclofenac-induced iatrogenic cutaneous necrosis. Postgrad Med J. 2020;96(1135):298–9. Chen Z, Zhang B, Wu D et al. Characteristics of predominantly right-sided colonic diverticulitis without need for colectomy. BMC Surg. 2020 Sep 14;20(1):202.
  • Pavlidis ET, Pavlidis TE. Current aspects on the management of perforated acute diverticulitis: A narrative review. Cureus. 2022 Aug 26;14(8):e28446.
There are 12 citations in total.

Details

Primary Language Turkish
Subjects Pathology
Journal Section Case Report / Case Series
Authors

Gülden Taşova Yılmaz 0000-0001-8921-3704

Filiz Özyiğit 0000-0002-0062-4281

Publication Date August 22, 2024
Submission Date June 6, 2024
Acceptance Date July 3, 2024
Published in Issue Year 2024 Volume: 4 Issue: 2

Cite

Vancouver Taşova Yılmaz G, Özyiğit F. Nadir Bir Olgu: Nikolay Sendromu. HMJ. 2024;4(2):70-3.

e-ISSN: 2791-9935