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Acetaminophen Toxicosis in a Cat

Year 2017, Volume: 1 Issue: 1, 1 - 4, 13.04.2017
https://doi.org/10.30704/http-www-jivs-net.295062

Abstract

Acetaminophen causes serious problems as toxication in cats in spite of being an effective and reliable analgesic and antipyretic in humans. A six months-old female cat suffering from cough was presented to examination to International Pet Hospital/Tirana/Albania when no result was obtained after one  acetaminophen tablet had been administered in order to heal the disease. Depression, grey and cyanotic mucous membranes and tongue, tachypnea, tachycardia, hypothermia were primary clinical signs. The color of blood and urine were darkened. On the basis of anamnesis and clinical findings,  a definitive diagnosis of acetaminophen toxicosis was made. Therapeutic protocol contained blood transfusion, N-Acetylcysteine, ascorbic acid, cimeditine and IV fluid therapy. Patient's blood samples were collected for haemogram and serum analyses with regular intervals was cured with appropriate treatment.

References

  • Allen, A. L. (2003). The diagnosis of acetaminophe toxicosis in a cat. Canadian Veterinary Journal, 44, 509-510.
  • Anvik, J. O. (1984). Acetaminophen toxicosis in a cat. Canadian Veterinary Journal, 25, 445-447.
  • Denzoin Vulcano, L. A., Confalonieri, O., Franci, R.,  Tapia, M. O., & Soraci, A .L. (2013). Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Veterinary Journal, 3(1). 56-63.
  • Ettinger, S. J. & Feldman, E. C. (2010). Textbook of veterinary internal medicine vol 2.  Philadelphia, US: W.B. Saunders.
  • Khan, S. A. (2016). Analgesics (Toxicity). In S. E. Aiello, & M. A. Moses (Eds), The Merck Veterinary Manual 11th ed. Retrieved from http://www.merckvetmanual.com/toxicology/toxicities-from-human-drugs/analgesics-toxicity.
  • Landin, J. S., Cohen, S. D. & Khairallah, E. A. (1996). Identification of a54-kDa mitochondrial acetaminophen-binding protein as aldehydedehydrogenase. Toxicology and Applied Pharmacology, 141(1), 299-307.
  • McConkey, S. E., Grant, D. M., & Cribb, A. E. (2009). The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats. Journal of Veterinary Pharmacology and Therapeutics, 32(6), 585-95.
  • Plunkett, S. J. (2001). Emergency procedures for the small animal veterinarian 2nd ed. London, W.B. Saunders.
  • Richardson, J. A. (2000). Management of acetaminophen and ibufrofen toxicoses in dogs and cats. Journal of Veterinary Emergency and Critical Care, 10(4), 285-291.
  • Sellon, R. K. (2013). Acetaminophen, In M. E. Peterson & A. P. Talcott (Ed). Small animal toxicology 3rd ed. (pp. 423-429). St Louis, US: W.B. Saunders.
  • Steenbergen, V. (2003). Acetaminophen and Cats. Retrieved from: http://aspcapro.org/sites/pro/files/a-vettech_0103_0.pdf Tennant, B. (2005). BSWA Small Animal Formulary 5th ed. Wetherby (Leeds), UK: Veterinary Publishing Company.

Acetaminophen Toxicosis in a Cat

Year 2017, Volume: 1 Issue: 1, 1 - 4, 13.04.2017
https://doi.org/10.30704/http-www-jivs-net.295062

Abstract

Acetaminophen causes serious problems as toxication in cats in spite of being an effective and reliable analgesic and antipyretic in humans. A six months-old female cat suffering from cough was presented to examination to International Pet Hospital/Tirana/Albania when no result was obtained after one  acetaminophen tablet had been administered in order to heal the disease. Depression, grey and cyanotic mucous membranes and tongue, tachypnea, tachycardia, hypothermia were primary clinical signs. The color of blood and urine were darkened. On the basis of anamnesis and clinical findings,  a definitive diagnosis of acetaminophen toxicosis was made. Therapeutic protocol contained blood transfusion, N-Acetylcysteine, ascorbic acid, cimeditine and IV fluid therapy. Patient's blood samples were collected for haemogram and serum analyses with regular intervals was cured with appropriate treatment.



 

References

  • Allen, A. L. (2003). The diagnosis of acetaminophe toxicosis in a cat. Canadian Veterinary Journal, 44, 509-510.
  • Anvik, J. O. (1984). Acetaminophen toxicosis in a cat. Canadian Veterinary Journal, 25, 445-447.
  • Denzoin Vulcano, L. A., Confalonieri, O., Franci, R.,  Tapia, M. O., & Soraci, A .L. (2013). Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Veterinary Journal, 3(1). 56-63.
  • Ettinger, S. J. & Feldman, E. C. (2010). Textbook of veterinary internal medicine vol 2.  Philadelphia, US: W.B. Saunders.
  • Khan, S. A. (2016). Analgesics (Toxicity). In S. E. Aiello, & M. A. Moses (Eds), The Merck Veterinary Manual 11th ed. Retrieved from http://www.merckvetmanual.com/toxicology/toxicities-from-human-drugs/analgesics-toxicity.
  • Landin, J. S., Cohen, S. D. & Khairallah, E. A. (1996). Identification of a54-kDa mitochondrial acetaminophen-binding protein as aldehydedehydrogenase. Toxicology and Applied Pharmacology, 141(1), 299-307.
  • McConkey, S. E., Grant, D. M., & Cribb, A. E. (2009). The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats. Journal of Veterinary Pharmacology and Therapeutics, 32(6), 585-95.
  • Plunkett, S. J. (2001). Emergency procedures for the small animal veterinarian 2nd ed. London, W.B. Saunders.
  • Richardson, J. A. (2000). Management of acetaminophen and ibufrofen toxicoses in dogs and cats. Journal of Veterinary Emergency and Critical Care, 10(4), 285-291.
  • Sellon, R. K. (2013). Acetaminophen, In M. E. Peterson & A. P. Talcott (Ed). Small animal toxicology 3rd ed. (pp. 423-429). St Louis, US: W.B. Saunders.
  • Steenbergen, V. (2003). Acetaminophen and Cats. Retrieved from: http://aspcapro.org/sites/pro/files/a-vettech_0103_0.pdf Tennant, B. (2005). BSWA Small Animal Formulary 5th ed. Wetherby (Leeds), UK: Veterinary Publishing Company.
There are 11 citations in total.

Details

Subjects Veterinary Surgery
Journal Section Case reports
Authors

Burçak Özkan

Publication Date April 13, 2017
Published in Issue Year 2017 Volume: 1 Issue: 1

Cite

APA Özkan, B. (2017). Acetaminophen Toxicosis in a Cat. Journal of Istanbul Veterinary Sciences, 1(1), 1-4. https://doi.org/10.30704/http-www-jivs-net.295062

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