Inherited Diseases of Holstein Cattle: Story So Far in Turkey

Year 2017, Volume: 1 Issue: 2, 40 - 46, 21.08.2017

Kozet Avanus , Ahmet Altınel

https://doi.org/10.30704/http-www-jivs-net.324403

Cited By: 5

Abstract

Inherited diseases are caused by recessive alleles proceed from increased inbreeding in Holstein cattle population. Bovine leucocyte adhesion deficiency (BLAD), deficiency of uridine monophosphate synthase enzyme (DUMPS), complex vertebral malformation (CVM), factor XI deficiency (FXID) and bovine citrulinaemia (BC) are the most frequent inherited diseases in Holstein cattle population. The prevalence for carriers of BLAD, DUMPS, CVM, FXID and BC diseases were reported highest in Denmark (21.5%), USA (1.2%), Japan (32.5%), Turkey (18%) and Australia (13%) respectively. Moreover the highest prevalence for carriers of BLAD, CVM and FXID were reported as 2.2%, 3.4%  and 18% respectively in Turkey so far. Neither DUMPS nor BC carriers were identified in Turkey so far. However further studies are required in order to identify the provinces that have risks for mutant alleles of inherited diseases in Turkey. Determining the carrier animals and exclude them from breeding is the only solution for eradication studies of inherited diseases.

 

Keywords

Holstein, inherited disease, BLAD, DUMPS, CVM, FXID, BC

References

• Adamov, N., Mitrov, D., Esmerov, I., & Dovc, P. (2014). Detection of recessive mutations (BLAD and CVM ) in Holstein-Friesian cattle population in Republic of Macedonia. Macedonian Veterinary Review, 37(1), 61–68. http://doi.org/10.14432/j.macvetrev.2013.11.005
• Agerholm, J. S., Bendixen, C., Andersen, O., & Arnbjer, J. (2001). Complex vertebral malformation in Holstein calves. J Vet Diagn Invest, 13,283–289.
• Agerholm, J. S., Bendixen, C., Arnbjerg, J., & Andersen, O. (2004). Morphological variation of “complex vertebral malformation” in Holstein calves. J Vet Diagn Invest, 16,548-553.
• Akyüz, B. (2013). Türkiye’deki iki farkli işletmede yetiştirilen Holştayn boğalarda faktör XI yetmezliği (FXID) allel frekansının belirlenmesi. Kafkas Universitesi Veteriner Fakultesi Dergisi, 19(1), 127–131. http://doi.org/10.9775/kvfd.2012.7354
• Akyüz, B., Bayram, D., Ertuğrul, O., & İşcan, K. M. (2008). Türkiye’de yetiştirilen Holştayn ve bazı yerli sığır ırklarında Citrullinemia allelinin belirlenmesi. J Fac Vet Med Univ Erciyes, 5(1), 17–20.
• Akyüz, B., & Ertuğrul, O. (2006). Detection of bovine leukocyte adhesion deficiency (BLAD) in Turkish native and Holstein cattle. Acta Veterinaria Hungarica, 54(2), 173–178. http://doi.org/10.1556/AVet.54.2006.2.4
• Akyüz, B., & Ertuğrul, O. (2008). Türkiye’de Holştayn ve yerli sığırlarda üridin monofosfat senteaz eksikliğinin (DUMPS) belirlenmesi. Ankara Üniv Vet Fak Derg, 55, 57–60.
• Akyüz, B., & Kul, B. Ç. (2009). Türkiye’deki holştayn ineklerde üridin monofosfat senteaz eksikliğinin (DUMPS) belirlenmesi. Ankara Üniv Vet Fak Derg, 56, 231–232.
• Akyüz, B, Sarıözkan, S, Bayram D: Factor XI mutation in normally fertile and repeat breeding Holstein cows in the Middle Anatolian region of Turkey: A financial approach. Anim Prod Sci, 52, 1042-1045, 2012.
• Akyüz, B., Sarıözkan, S., & Bayram, D. (2015). The prevalence of BLAD and comparison of some production parameters in carrier and non-carrier Holstein cows in Kayseri province, Turkey. J Fac Vet Med Univ Erciyes, 12(1), 31–35.
• Avanus, K., & Altınel, A. (2016a). Identification of allele frequency of factor XI deficiency (FXID) in Holstein cows reared in Thrace region of Turkey. J. Fac. Vet. Med. Istanbul Univ, 42(2), 190–193. http://doi.org/10.16988/iuvfd.2016.53309
• Avanus, K., & Altınel, A. (2016b, June, 1-4). Identification of Allele Frequency of SLC35A3 Gene Causing Complex Vertebral Malformation (CVM) in Holstein Cows Reared in Thrace Region and Comparing Three Methods Use in Determination of Carriers. Paper presented at VI. Ulusal Veteriner Zootekni Kongresi, Nevşehir, Turkey.
• Berglund, B., Persson, A., & Stalhammar, H. (2004). Effects of complex vertebral malformation on fertility in Swedish Holstein cattle. Acta Vet Scand, 45,161-165.
• Biochard, D., Coquereau, J. A., & Amiques, Y. (1995, Sep, 4-7) Effect of bovine leukocyte adhesion deficiency genetic defect in Holstein cattle under farm condition. Paper presented at 46th Annual Meeting of the European Association for Animal Production, Prague, Czech Republic.
• Citek, J., Rehout V., Hajkova, J., & Pavkova, J. (2006). Monitoring of the genetic health of cattle in the Czech Republic. Vet Med, 51, 333–339.
• Citek, J., Rehout, V., Hanusova, L., & Vrabcova, P. (2008). Sporadic incidence of factor XI deficiency in Holstein cattle. Journal of the Science of Food and Agriculture, 88, 2069–2072.
• Czarnik, U., Zabolewicz, T., Galinski, M., Pareek, C. S., & Walawski, K. (2004).Silent point mutation polymorphism of the bovine CD18 encoding gene. Journal of Applied Genetics, 45, 73–76.
• Fesüs, L., Zsolnai, A., Anton, I., Barany, I., & Bozo, S. (1999). BLAD genotypes and cow production traits in Hungarian Holsteins. Journal of Animal Breeding and Genetics, 116, 169-174.
• Ghanem, M. E., Nishibori, M., Nakao, T., Nakatani, K., & Akita, M. (2005). Factor XI mutation in a Holstein cow with repeat breeding in Japan. Journal of Veterinary Medical Science, 67, 713–715.
• Ghanem, M. E., Akita, M., Suzuki, T., Kasuga, A., & Nishibori, M. (2008). Complex vertebral malformation in Holstein cows in Japan and its inheritance to crossbred F1 generation. Anim Reprod Sci, 103, 348-354.
• Grupe, S., Dietle, G., & Schwerin, M. (1996). Population survey of citrullinaemia on German Holsteins. Livestock Production Science, 45, 35-38.
• Hagemoser, W. A., Roth, J. A., Löfsted, J., & Fagerland, J. A. (1983). Granulocytopathy in a Holstein heifer. J Am Vet Med Assoc, 183, 1093-1094.
• Healy, P. J, Dennis, J. A., Camilleri, L. M., Robinson, J. L., Stell, A. L., & Shanks, R. D. (1991). Bovine citrullinemia traced to sire of Linrnack Kriss King. Australian Veterinary Journal, 1(68), 155.
• Hemati, B., Fazeli, M. H., Namvar, Z., & Ranji, M. (2015). Investigation of bovine leukocyte adhesion deficiency (BLAD) and complex vertebral malformation (CVM) in a population of Iranian Holstein cows. Iranian Journal of Applied Animal Science, 5(1), 69–72.
• Jorgensen, C. B., Agerholm, J. S., Pedersen, J., & Thomsen, P. D. (1993). Bovine leukocyte adhesion deficiency in Danish Holstein-Friesian cattle: PCR screening and allele frequency estimation. Acta Vet Scand, 34, 231–236.
• Kamiñski, S., Grzybowski, G., Prusak, B., & Rusc, A. (2005). No incidence of DUMPS carriers in Polish dairy cattle. J Appl Genet, 46, 395–397.
• Karslı, T., Şahin, E., Argun Karslı, B., Alkan, S., & Balcıoğlu, S. M. (2011). Identification of alleles for factor XI ( FXID ) and uridine monophosphate synthase (DUMPS ) deficiencies in Holstein cows reared in Antalya. Kafkas Universitesi Veteriner Fakultesi Dergisi, 17(3), 503–505.
• Kaya, M., Meydan, H., Kıyma, Z., Alan, M., & Yildiz, M. A. (2016). Screening for bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, bovine citrullinaemia and factor XI deficiency in Holstein cattle. Indian Journal of Animal Sciences, 86(8), 900–903.
• Kehrli, M. E., Schmalstieg, C., Anderson, D. C., Van Der Maaten, M. J., Hughes, B. J., Akermann, M. R., Wilhemsen, C. L., Brown, G. B., Stevens, M. G., & Whetstone, C. A. (1990). Molecular definition of the bovine granulocytopathy syndrome: Identification of deficiency of the Mac-1 (CD11b/CD18) glycoprotein. Am J Vet Res, 51, 1826-1836.
• Kepenek, E. Ş. (2007). Polymorphism of prolactin (PRL), diacylglycerol acyltransferase (DGAT-1) and bovine solute carrier family 35 member 3 (SLC35A3) genes in native cattle breeds and its implication for Turkish cattle breeding. Master Thesis, Middle East Technical University, Ankara, Turkey.
• Konersmann, Y., Wemheuer, W., & Brenig, B. (2003). Herkunft, verbreitung und bedeutung des CVM gendefekts in der Holstein Friesian population. Züchtungskd, 75, 9-15.
• Korkmaz Ağaoğlu, Ö., Ağaoğlu, A. R., & Saatci, M. (2015). Estimating allele frequencies of some hereditary diseases in Holstein cattle reared in Burdur province, Turkey. Turkish Journal of Veterinary and Animal Sciences, 39(3), 338–342. http://doi.org/10.3906/vet-1412-13.
• Kulaklı, G. N., & Akyüz, B. (2011). Kayseri bölgesinde yetiştirilen Holştayn sığırlarında kompleks vertebral malformasyon hastalığı geninin allel frekansının belirlenmesi. J Fac Vet Med Univ Erciyes, 8(2), 69–74.
• Li, J., Wang, H., Zhang, Y., Hou, M., Zhong, J., & Zhang, Y. (2011). Identification of BLAD and citrullinemia carriers in Chinese Holstein cattle. Anim Sci Pap Rep, 29, 37–42.
• Marron, B. M., Robinson, J. L., Gentry, P. A., & Beever, J. E. (2004). Identification of a mutation associated with factor XI deficiency in Holstein cattle. Animal Genetics, 35, 454–56.
• Meydan, H., Yildiz, M. a, Ozdil, F., Gedik, Y., & Ozbeyaz, C. (2009). Identification of factor XI deficiency in Holstein cattle in Turkey. Acta Veterinaria Scandinavica, 51, 5. http://doi.org/10.1186/1751-0147-51-5
• Meydan, H., Yildiz, M. A., & Agerholm, J. S. (2010). Screening for bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, complex vertebral malformation, bovine citrullinaemia, and factor XI deficiency in Holstein cows reared in Turkey. Acta Veterinaria Scandinavica, 52, 56. http://doi.org/10.1186/1751-0147-52-56
• Nagahata, H., Noda, H., Takahashi, K., Kurosawa, T., & Sonoda, M. (1987). Bovine granulocytopathy syndrome, neutrophil dysfunction in Holstein Friesian calves. J Vet Med, 34, 445-451.
• Nagahata, H., Nochi, H., Tamto, K., Tani, Yama, H., Noda, H., Morita, M., Kanamaki, M., & Kociba, G. J. (1993). Bovine leukocyte adhesion deficiency in Holstein cattle. Can J Vet Res, 55, 40–48.
• Nagahata, H., Oota, H., Nitanai, A., Oikawa, S., Higushi, H., Nakade, T., Kurosawa, T., Morita, M., Ogawa, H. (2002). Complex vertebral malformation in a stillborn Holstein calf in Japan. J Vet Med Sci, 64, 1107-1112.
• Nasreen, F., Altaf, M. N., Naeem, R. M., & Anver, Q. J. (2009). Detection and screening of bovine leukocyte adhesion deficiency in Pakistan using molecular methods. Hereditas, 146(2), 74-78.
• Natonek, M. (2000). Identification of BLAD mutation in cattle with PCR-RFLP method. Biuletyn Informacyjny Instytutu Zootechniki, 38, 29–33.
• Norouzy, A., Nassiry, M. R., Eftekhari, S. F., Javadmanesh, A., Mohammad, A. M. R., & Sulimova, G. E. (2005). Identification of bovine leukocyte adhesion deficiency (BLAD) carriers in Holstein and Brown Swiss AI bulls in Iran. Russian Journal of Genetics, 41, 1409–1413.
• Oner, Y., Keskin, A., & Elmaci, C. (2010). Identification of BLAD, DUMPS, citrullinamia and FXI deficiency in Holstein cattle in Turkey. Asian Journal of Animal and Veterinary Advances, 5, 60–65.
• Padeeri, M., Vijaykumar, K., Grupe, S., Narayan, M. P., Schwerin, M., & Kumar, M. H. (1999). Incidence of hereditary citrullinaemia and bovine leucocyte adhesion deficiency syndrome in Indian dairy cattle (Bos taurus, Bos indicus) and buffalo (Bubalus Bubalis) population. Arch. Tierz. 42, 347-352.
• Patel, M., Patel, R. K., Singh, K. M., Rank, D. N., Thakur, M. C., & Khan, A. (2011). Detection of genetic polymorphism in CD18 gene in cattle by PCR-RFLP. Wayamba Journal of Animal Science, 11, 110-111.
• Patel, R. K., Singh, K. M., Soni, K. J., Chauhan, J. B., & Sambasiva, Rao K. R. S. (2006). Lack of carriers of citrullinaemia and DUMPS in Indian Holstein cattle. Journal of Applied Genetics, 47(3), 239-242.
• Patel, R. K., Singh, K. M., Soni, K. J., Chauhan, J. B., & Sambasiva, Rao K. R. S. (2007). Low incidence of bovine leukocyte adhesion deficiency (BLAD) carriers in Indian cattle and buffalo breeds. Journal of Applied Genetics, 48(2),153-155.
• Poli, M. A., Dewey, R., Semorile, L., Lozano, M. E., Albarino, C. G.,Romanowski, V. & Grau, O. (1996). PCR screening for carriers of bovine leukocyte adhesion deficiency (BLAD) and uridine monophosphate synthase (DUMPS) in Argentine Holstein cattle. Journal of Veterinary Medicine Series, 43, 163–168.
• Powell, R. L., Norman, H. D., & Cowan, C. M. (1996). Relationship of bovine leukocyte adhesion deficiency with genetic merit for performance traits. Journal of Dairy Science, 79, 895-899.
• Rajesh, K. P., Kalpesh, J. S., Jenabhai, B. C., Krishna, M. S., Krothapalli, R. S., & Sambasiva, R. (2007) Factor XI deficiency in Indian Bos taurus, Bos indicus, Bos taurus × Bos indicus crossbreds and Bubalus bubalis. Genet Mol Biology, 30(3), 580-583.
• Riberio, A. L., Baron, E. E., Martinez, M. L. & Coutinho, L. L. (2000). PCR screening and allele frequency estimation of bovine leukocyte adhesion deficiency in Holstein and Gir cattle in Brazil. Genetics and Molecular Biology, 23, 831–834.
• Riojas-Valdes, V. M., Carballo-Garcia, B., Rodriguez-Tovar, L. E., Garza-Zermeno, M. V., Ramirez-Romero, R., Zarate-Ramos, J., Avalos-Ramirez, R., & Davalos-Aranda, G. (2009). Absence of bovine leukocyte adhesion deficiency (BLAD) in Holstein cattle from Mexico. Journal of Animal and Veterinary Advances, 8(9), 1870-1872.
• Robinson, J. L., Burns, J. L., Magura, C. E., & Shanks, R. D. (1993). Low incidence of citrullinemia carriers among dairy cattle of the United States. Journal of Dairy Science, 76 (3), 853–858.
• Rusc, A., & Kaminski, S. (2007). Prevalence of complex vertebral malformation carriers among Polish Holstein-Friesian bulls. J Appl Genet, 48, 247-252. DOI:10.1007/BF03195219
• Shanks, R. D., & Robinson, J. (1990). Deficiency of uridine monophosphate synthase among Holstein cattle. The Cornell Veterinarian, 80, 119–22.
• Shuster, D. E., Kehrli, M. E. Jr, Ackermann, M. R., & Gilbert, R. O. (1992). Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle. Proc Natl Acad Sci, 89, 9225–9229.
• Schütz, E., Scharfenstein, M., & Brenig, B. (2008). Implication of complex vertebral malformation and bovine leukocyte adhesion deficiency DNA-based testing on disease frequency in the Holstein population. Journal of Dairy Science, 91(12), 4854–9. http://doi.org/10.3168/jds.2008-1154
• Şahin, E., Karslı, T., Galiç, A., & Balcıoğlu, M. S. (2013). Identification of bovine leukocyte adhesion deficiency (BLAD) and bovine citrullinaemia (BC) alleles in Holstein cows reared in Antalya region. Journal of Applied Animal Research, 41(1), 56–60. http://doi.org/10.1080/09712119.2012.738221
• Tainturier, D., Grobet, L., Brouwers, B., Bruyas, J. F., Fieni, F., Battut, I., Lecoanet, J., Douart, A., Breyton, I., & Duclos, P. (1995). Observations on three cases of bovine leukocyte adhesion deficiency (BLAD). Revue-de Medecine Veterinaire, 146(3), 189-195.
• Thomsen, B., Horn, P., Panitz, F., Bendixen, E., Petersen, A. H., Holm, L. E., Nielsen, V. H., Agerholm, J. S., Arnbjerg, J., & Bendixen, C. (2006). A missense mutation in the bovine SLC35A3 gene, encoding a UDP-Nacetylglucosamine transporter, causes complex vertebral malformation. Genome Reserch, 16, 97–105.
• Utami, M. (2015). Identification of complex vertebral malformation (CVM) of dairy cattle in Enrekang regency. PhD thesis, Hasanuddin University, Makkasar, Indonesia.
• Yaşar, G., & Akyüz, B. (2012). Kayseri civarında yetiştirilen Holştayn ineklerde kalıtsal faktör XI yetmezliği geninin allel frekansının belirlenmesi. Erciyes Üniv Vet Fak Derg, 9(91), 7–12.