Virus Imaging Tools

Year 2020, Volume: 4 Issue: 2, 75 - 83, 29.08.2020

Beyhan Sareyyüpoğlu

Abstract

Viruses are very small physical particles that can not be observed with a normal microscope. Only the largest virus, the poxvirus can be seen in the light microscope. Other tools are required for a detailed examination of viruses in ultrastructural size. Especially for the last 20 years, these advanced and ongoing tools have been used in the investigation of the biological molecules and biological processes of viruses. With the help of virus imaging tools, viruses can be identified in clinical samples, thereby explaining the detailed life cycle of the virus. Thus, these tools help the creation of new and safe vaccines and antiviral medicine. In this review, electron microscopy (EM) tools were given as scanning electron microscopy (SEM), transmission electron microscopy (TEM), cryo-electron microscopy (Cryo-EM) since generally used tools based on EM. Besides EM-based tools, X-ray crystallography which is the basis for cryo-EM and atomic force microscopy (AFM) that is relatively economic and easy to apply compared to other microscopies were also described.

Keywords

virus, visualisation, equipments

Supporting Institution

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Project Number

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Thanks

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