The effect of coenzyme Q10 on blood plasma nitric oxide and total antioxidant capacity levels in hypothyroidism-induced rats

Year 2021, Volume: 5 Issue: 1, 19 - 26, 30.04.2021

Cemşah Yazıcı , Tufan Keçeci , Durmuş Hatipoğlu

https://doi.org/10.30704/http-www-jivs-net.851210

Cited By: 1

Abstract

In this study, the effect of coenzyme Q10 (CoQ10) on nitric oxide (NO) and total antioxidant (TAS) capacity in rats for which experimentally hypothyroidism was induced through PTU was investigated. A total of 32 healthy male Wistar Albino rats weighing 300-350g, approximately 12 weeks old, were used as animal material in the study. . Rats were divided into 4 experimental groups as control (K), Coenzyme Q10 (C), Hypothyroidism (H), and Coenzyme Q10 + Hypothyroidism (CH). During the trial period of three weeks, 3mg CoQ10 (10mg/kg/day) was dissolved in 0.3 ml of maize oil and intraperitoneally administered for each animal in group C. In group H, PTU has added to drinking water daily at a weight/volume (w/v) ratio of %0.05. In the HC group, coenzyme Q10 was administered intraperitoneally and PTU was administered with drinking water at a rate of %0.05. TT4, TT3, and TSH levels were determined in serum samples and NO and TAS levels in plasma samples. In the present study; the highest plasma NO level among the groups was determined in group H (p<0.05) and there was no significant difference between other groups (H, C, HC) (p>0.05). The plasma TAS value of group H was found to be significantly higher than the same value in the K, C and HC groups (p<0.05). The plasma TAS level in group C had no difference from the same value in the HC group (p>0.05), although it was higher than the same value of group K (p<0.05). As a result, it was found to cause oxidative stress in hypothyroidism-induced rats with a particular increase in plasma NO levels, and CoQ10 was found to be effective in normalizing the increased plasma NO level due to hypothyroidism.

Keywords

hypothyroidism, coenzyme q10, nitric oxide, total antioxidant capacity, rats

Supporting Institution

BAP

Project Number

19202014

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