Zencefilin Eczacılıktaki Yeri ve Antitümör Etkisi
Year 2018,
Volume: 38 Issue: 2, 76 - 84, 15.06.2018
Ş.rumeysa Osmanlıoğlu-dağ
Ayşe Kuruüzüm-uz
Abstract
Zencefil (Zingiber officinale Roscoe, Zingiberaceae) tüm dünyada yaygın olarak tüketilen geleneksel tıbbi bir bitkidir. Genellikle gıda/baharat amaçlı tüketilmesine rağmen, tedavi amacıyla da birçok hasta tarafından tüketilmektedir. İçerisindeki aktif bileşenler, güçlü etkilere sahip gingeroller ve şogaollerdir. Son zamanlarda zencefilin antikanser etkisi üzerinde yapılan çalışmalar artmıştır. Zencefilde bulunan bazı bileşenlerin güçlü antioksidan ve antienflamatuvar etkileri vardır ve bunların bazıları deneysel karsinogenezde anti-tümör aktivite göstermişlerdir. Bu çalışmada zencefilin eczacılıktaki yeri ve çeşitli kanser türleri üzerindeki etkisi ile ilgili bilimsel araştırmalar derlenmiştir.
References
- 1. Zingiberis rhizoma, ESCOP Monographs 2nd ed.Suppl. 2009: pp
289-303.
- 2. Baytop AT: Farmasötik Botanik Ders Kitabı. İ.Ü. Basımevi ve Film
Merkezi; İstanbul, Türkiye, 1996.
- 3. Farnsworth RF, Fong HHS, Mahady GB. Zingiber officinale. In:
WHO Monographs on Selected Medicinal Plants Volume 1, WHO
Publications; Geneva, Switzerland. 1999: pp 277-287.
- 4. Rahmani AH, Al Shabrmi FM, Aly SA: Active ingredients of ginger
as potential candidates in the prevention and treatment of diseases
via modulation of biological activities. International Journal of
Physiology Pathophysiology and Pharmacology 2014, 6(2):125-136.
- 5. Kaplan H: Zencefilin (Zingiber Officinale Roscoe) Bitkisel Özellikleri
ve Yetiştiriciliği. Derim dergisi 2005, 22(2):1-9.
- 6. Bode AM, Dong Z. Chapter 7-The Amazing and Mighty Ginger. In:
Benzie IFF, Wachtel-Galor S (eds), Herbal Medicine: Biomolecular
and Clinical Aspects 2nd edition. CRC Press/Taylor & Francis; Boca
Raton, Florida. 2011: pp 131-156.
- 7. http://myherbsweblog.blogspot.com.tr/2010/11/ginger-plant-is-that.
html.
8. Surh YJ, Lee E, Lee JM: Chemoprotective properties of some pungent
ingredients present in red pepper and ginger. Fundamental and
Molecular Mechanisms of Mutagenesis 1997, 402 (1998):259–267.
- 9. Choudhury D, Das A, Bhattacharya A, Chakrabarti G: Aqueous
extract of ginger shows antiproliferative activity through disruption
of microtubule network of cancer cells. FoodChem. Toxicol. 2010,
48(10):2872–2880.
- 10. Manju V, Nalini N: Chemopreventive efficacy of ginger, a naturally
occurring anticarcinogen during the initiation, post-initiation stages
of 1,2 dimethylhydrazine-induced colon cancer. Clin. Chim. Acta
2005, 358(1-2):60–67.
- 11. Park KK, Chun KS, Lee JM, Lee SS, Surh J: Inhibitoryeffects of
6-gingerol, a major pungent principle of ginger, on phorbol ester-induced
inflammation, epidermal ornithine decarboxylase activity and
skin tumor promotion in ICR mice. Cancer Lett. 1998,129(2):139–
144.
- 12. Prasad S, Tyagi AK: Ginger and Its Constituents: Role in prevention
and treatment of gastrointestinal cancer. Gastroenterology Research
and Practice 2015,1-11.
- 13. Sang S, Hong J, Wu H, Liu J, Yang CS, Pan M, Badmaev V, Ho
CT: Increased growth inhibitory effects on human cancer cells and
anti-Inflammatory potency of shogaols from Zingiber officinale
relative to gingerols. Journal of Agricultural and Food Chemistry
2009, 57(22):10645–10650.
- 14. Lin CB, Lin CC, Tsay GJ: 6-Gingerol inhibits growth of colon cancer
cell LoVo via induction of G2/M Arrest. Evidence-Based Complementary
and Alternative Medicine 2012, 1-7.
- 15. Radhakrishnan EK, Bava SV, Narayanan SS, Nath LR, Thulasidasan
AKT, Soniya EV, Anto RJ: [6]-Gingerol induces Caspase-dependent
apoptosis and prevents PMA-induced proliferation in colon cancer
cells by Inhibiting MAPK/AP-1 Signaling. PLoS ONE 2014, 9(8):1-
13.
- 16. Wee LH, Morad NA, Aan GJ, Makpol S, Ngah WZW, Yusof YAM:
Mechanism of Chemoprevention against colon cancer cells using
combined gelam honey and ginger extract via mTOR and Wnt/β-catenin
pathways. Asian Pacific Journal of Cancer Prevention 2015,
16(15):6549-6556.
- 17. Park GH, Park JH, Song HM, Eo HJ, Kim MK, Lee JW, Lee MH, Cho
KH, Lee JR, Cjo HJ, Jeong JB: Anti-cancer activity of Ginger (Zingiber
officinale) leaf through the expression of activating transcription
factor 3 in human colorectal cancer cells. BMC Complementary and
Alternative Medicine 2014, 14(408):1-8.
- 18. Zick SM, Turgeon DK, Vareed SK, Ruffin MT, Litzinger AJ, Wright
BD, Alrawi S , Normolle DP, Djuric Z, Brenner DE: Phase II Study
of the effects of ginger root extract on eicosanoids in colon mucosa
in people at normal risk for colorectal cancer, Cancer Prevention
Research 2011, 4(11):1929–1937.
- 19. Jiang Y, Turgeon DK, Wright BD, Sidahmed E, Ruffin MT, Brenner
DE, Sen A, Zick SM: Effect of ginger root on cyclooxygenase-1
and 15hydroxyprostaglandin dehydrogenase expression in colonic
mucosa of humans at normal and increased risk of colorectal cancer.
Eur J Cancer Prev. 2013, 22(5):455–460.
- 20. Citronberg J, Bostick R, Ahearn T, Turgeon DK, Ruffin MT, Djuric
Z, Sen A, Dean E. Brenner DE, Zick SM: Effects of ginger supplementation
on cell cycle biomarkers in the normal-appearing colonic
mucosa of patients at increased risk for colorectal cancer: Results
from a Pilot, Randomized, Controlled Trial. Cancer Prevention
Research 2013, 6(4):271–281.
- 21. Plengsuriyakarn T, Viyanant V, Eursitthichai V, Tesana S, Chaijaroenkul
W, Itharat A, Na-Bangchang K: Cytotoxicity, toxicity, and
anticancer activity of zingiber officinale Roscoe Against Cholangiocarcinoma.
Asian Pacific Journal of Cancer Prevention 2012,
13(9):4597-4606.
- 22. Yue Zhou Y, Li Y, Zhou T, Zheng J, Li S, Li HB: Dietary natural
products for prevention and treatment of liver cancer. Nutrients
2016, 8(3):156.
- 23. Mansour MA, Bekheet SA, Al-Rejaie SS, Al-Shabanah OA,
Al-Howiriny TA, Al-Rikabi AC, Abdo AA: Ginger ingredients inhibit
the development of diethylnitrosoamine induced premalignant
phenotype in rat chemical hepatocarcinogenesis model. Biofactors
2010, 36(6):483–490.
- 24. Habib SH, Makpol S, Abdul HN, Das S, Ngah WZ, Yusof YA:
Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory
effects on ethionine-induced hepatoma rats. Clinics 2008,
63(6):807–813.
- 25. Vijaya PV, Arul DCS, Ramkuma KM: Induction of apoptosis by
ginger in HEp-2 cell line is mediated by reactive oxygen species.
Basic Clin. Pharmacol. Toxicol. 2007, 100(5):302–307.
- 26. Weng CJ, Wu CF, Huang HW, Ho CT, Yen GC: Anti-invasion
effects of 6-shogaol and 6-gingerol, two active components in ginger,
on human hepatocarcinoma cells. Mol. Nutr. Food Res. 2010,
54(11):1618–1627.
- 27. Yusof YAM, Ahmad N, Das S, Sulaiman S, Murad NA: Chemopreventive
efficacy of ginger (Zingiber officinale) in ethionine induced
rat hepatocarcinogenesis. African Journal of Traditional, Complementary
and Alternative Medicines 2009, 6(1):87-93.
- 28. Akimoto M, Iizuka M, Kanematsu R, Yoshida M, Takenaga K:
Anticancer effect of ginger extract against pancreatic cancer cells
mainly through reactive oxygen Species-mediated autotic cell death.
Plos One 2015, 10(5):1-22.
- 29. Karna P, Chagani S, Gundala SR, Rida PCG, Asif G, Sharma V,
Gupta MV, Aneja R: Benefits of whole ginger extract in prostate
cancer. Br J Nutr 2012, 107(4):473–484.
- 30. Elkady AI, Abuzinadah OA, Baeshen NA, Rahmy TR: Differential
control of growth, apoptotic activity, and gene expression in human
breast cancer cells by extracts derived from medicinal herbs Zingiber
officinale. Journal of Biomedicine and Biotechnology 2012,1-
- 31. Ray A, Vasudevan S, Sengupta S: 6-Shogaol inhibits breast cancer
cells and stem cell-like spheroids by modulation of Notch Signaling
Pathway and induction of autophagic cell death. PLoSONE 2015,
10(9):1-22.
- 32. Rastogi N, Duggal S, Singh SK, Porwal K, Srivastava VK, Maurya
R, Bhatt MLB, Mishra DP: Proteasome inhibition mediates p53
reactivation and anticancer activity of 6-Gingerol in cervical cancer
cell. Onkotarget 2015, 6(41):43310-25.
- 33. Rhode J, Fogoros S, Zick S, Wahl H, Griffith KA, Huang J, Liu JR:
Ginger inhibits cell growth and modulates angiogenic factors in ovarian
cancer cells. BMC Complementary and Alternative Medicine
2007, 7(44):1-9.
- 34. Cheng Yao C, Oh JH, Oh IG, Park CH, Chung JH: [6]-Shogaol
inhibits melanogenesis in B16 mouse melanoma cells through
activation of the ERK pathway. Acta Pharmacologica Sinica 2013,
34 (2013):289–294.
- 35. Huang HC, Chang SJ, Wu CY, Ke HJ, Chang TM: [6]-Shogaol
Inhibits 𝛼-MSH-Induced Melanogenesis through the acceleration of
ERK and PI3K/Akt-mediated MITF degradation. BioMed Research
International 2014, 1-9.
- 36. Liu Q, Peng YB, Zhou P, Qi LW, Zhang M, Gao N, Liu EH, Li P:
6-Shogaol induces apoptosis in human leukemia cells through a
process involving caspase-mediated cleavage of eIF2α. Molecular
Cancer 2013, 12(135):1-12.
- 37. Lee DH, Kimb DV, Jungc CH, Leea YJ, Parkd D: Gingerol sensitizes
TRAIL-induced apoptotic cell death of glioblastoma cells. Toxicol
Appl Pharmacol 2014, 279(3): 253–265.
- 38. Liu Y, Whelan RJ, Pattnaik BR, Ludwig K, Subudhi E, Rowland H,
Claussen N, Zucker N, Uppal S, Kushner DM, Felder M, Patankar
MS, Kapur A: Terpenoids from Zingiber officinale (Ginger) induce
apoptosis in endometrial cancer cells through the activation of p53.
PLoS ONE 2012, 7(12):1-10.
- 39. Rahman S, Salehin F, Asif I: In vitro antioxidant and anticancer
activity of young Zingiber officinale against human breast carcinoma
cell lines. BMC Complementary and Alternative Medicine 2011,
11(76):1-7.
Ginger’s Place in Pharmacy and Antitumor Effect
Year 2018,
Volume: 38 Issue: 2, 76 - 84, 15.06.2018
Ş.rumeysa Osmanlıoğlu-dağ
Ayşe Kuruüzüm-uz
Abstract
Ginger (Zingiber officinale Roscoe, Zingiberaceae) is a traditional medical plant which is commonly consumed throughout the world. Although often used for food/spice, it is also taken by many patients for treatment. Its the most active ingredients are gingerols and shogaol which have strong effects. Research interest has recently increase on the anti-cancer effects of ginger. Some of the constituents present in ginger have potent antioxidant and anti-inflammatory effects while some others exhibit antitumor activity in experimental carcinogenesis. In this study, scientific researches on the place of ginger in pharmacy and its effect on various cancer types have been reviewed.
References
- 1. Zingiberis rhizoma, ESCOP Monographs 2nd ed.Suppl. 2009: pp
289-303.
- 2. Baytop AT: Farmasötik Botanik Ders Kitabı. İ.Ü. Basımevi ve Film
Merkezi; İstanbul, Türkiye, 1996.
- 3. Farnsworth RF, Fong HHS, Mahady GB. Zingiber officinale. In:
WHO Monographs on Selected Medicinal Plants Volume 1, WHO
Publications; Geneva, Switzerland. 1999: pp 277-287.
- 4. Rahmani AH, Al Shabrmi FM, Aly SA: Active ingredients of ginger
as potential candidates in the prevention and treatment of diseases
via modulation of biological activities. International Journal of
Physiology Pathophysiology and Pharmacology 2014, 6(2):125-136.
- 5. Kaplan H: Zencefilin (Zingiber Officinale Roscoe) Bitkisel Özellikleri
ve Yetiştiriciliği. Derim dergisi 2005, 22(2):1-9.
- 6. Bode AM, Dong Z. Chapter 7-The Amazing and Mighty Ginger. In:
Benzie IFF, Wachtel-Galor S (eds), Herbal Medicine: Biomolecular
and Clinical Aspects 2nd edition. CRC Press/Taylor & Francis; Boca
Raton, Florida. 2011: pp 131-156.
- 7. http://myherbsweblog.blogspot.com.tr/2010/11/ginger-plant-is-that.
html.
8. Surh YJ, Lee E, Lee JM: Chemoprotective properties of some pungent
ingredients present in red pepper and ginger. Fundamental and
Molecular Mechanisms of Mutagenesis 1997, 402 (1998):259–267.
- 9. Choudhury D, Das A, Bhattacharya A, Chakrabarti G: Aqueous
extract of ginger shows antiproliferative activity through disruption
of microtubule network of cancer cells. FoodChem. Toxicol. 2010,
48(10):2872–2880.
- 10. Manju V, Nalini N: Chemopreventive efficacy of ginger, a naturally
occurring anticarcinogen during the initiation, post-initiation stages
of 1,2 dimethylhydrazine-induced colon cancer. Clin. Chim. Acta
2005, 358(1-2):60–67.
- 11. Park KK, Chun KS, Lee JM, Lee SS, Surh J: Inhibitoryeffects of
6-gingerol, a major pungent principle of ginger, on phorbol ester-induced
inflammation, epidermal ornithine decarboxylase activity and
skin tumor promotion in ICR mice. Cancer Lett. 1998,129(2):139–
144.
- 12. Prasad S, Tyagi AK: Ginger and Its Constituents: Role in prevention
and treatment of gastrointestinal cancer. Gastroenterology Research
and Practice 2015,1-11.
- 13. Sang S, Hong J, Wu H, Liu J, Yang CS, Pan M, Badmaev V, Ho
CT: Increased growth inhibitory effects on human cancer cells and
anti-Inflammatory potency of shogaols from Zingiber officinale
relative to gingerols. Journal of Agricultural and Food Chemistry
2009, 57(22):10645–10650.
- 14. Lin CB, Lin CC, Tsay GJ: 6-Gingerol inhibits growth of colon cancer
cell LoVo via induction of G2/M Arrest. Evidence-Based Complementary
and Alternative Medicine 2012, 1-7.
- 15. Radhakrishnan EK, Bava SV, Narayanan SS, Nath LR, Thulasidasan
AKT, Soniya EV, Anto RJ: [6]-Gingerol induces Caspase-dependent
apoptosis and prevents PMA-induced proliferation in colon cancer
cells by Inhibiting MAPK/AP-1 Signaling. PLoS ONE 2014, 9(8):1-
13.
- 16. Wee LH, Morad NA, Aan GJ, Makpol S, Ngah WZW, Yusof YAM:
Mechanism of Chemoprevention against colon cancer cells using
combined gelam honey and ginger extract via mTOR and Wnt/β-catenin
pathways. Asian Pacific Journal of Cancer Prevention 2015,
16(15):6549-6556.
- 17. Park GH, Park JH, Song HM, Eo HJ, Kim MK, Lee JW, Lee MH, Cho
KH, Lee JR, Cjo HJ, Jeong JB: Anti-cancer activity of Ginger (Zingiber
officinale) leaf through the expression of activating transcription
factor 3 in human colorectal cancer cells. BMC Complementary and
Alternative Medicine 2014, 14(408):1-8.
- 18. Zick SM, Turgeon DK, Vareed SK, Ruffin MT, Litzinger AJ, Wright
BD, Alrawi S , Normolle DP, Djuric Z, Brenner DE: Phase II Study
of the effects of ginger root extract on eicosanoids in colon mucosa
in people at normal risk for colorectal cancer, Cancer Prevention
Research 2011, 4(11):1929–1937.
- 19. Jiang Y, Turgeon DK, Wright BD, Sidahmed E, Ruffin MT, Brenner
DE, Sen A, Zick SM: Effect of ginger root on cyclooxygenase-1
and 15hydroxyprostaglandin dehydrogenase expression in colonic
mucosa of humans at normal and increased risk of colorectal cancer.
Eur J Cancer Prev. 2013, 22(5):455–460.
- 20. Citronberg J, Bostick R, Ahearn T, Turgeon DK, Ruffin MT, Djuric
Z, Sen A, Dean E. Brenner DE, Zick SM: Effects of ginger supplementation
on cell cycle biomarkers in the normal-appearing colonic
mucosa of patients at increased risk for colorectal cancer: Results
from a Pilot, Randomized, Controlled Trial. Cancer Prevention
Research 2013, 6(4):271–281.
- 21. Plengsuriyakarn T, Viyanant V, Eursitthichai V, Tesana S, Chaijaroenkul
W, Itharat A, Na-Bangchang K: Cytotoxicity, toxicity, and
anticancer activity of zingiber officinale Roscoe Against Cholangiocarcinoma.
Asian Pacific Journal of Cancer Prevention 2012,
13(9):4597-4606.
- 22. Yue Zhou Y, Li Y, Zhou T, Zheng J, Li S, Li HB: Dietary natural
products for prevention and treatment of liver cancer. Nutrients
2016, 8(3):156.
- 23. Mansour MA, Bekheet SA, Al-Rejaie SS, Al-Shabanah OA,
Al-Howiriny TA, Al-Rikabi AC, Abdo AA: Ginger ingredients inhibit
the development of diethylnitrosoamine induced premalignant
phenotype in rat chemical hepatocarcinogenesis model. Biofactors
2010, 36(6):483–490.
- 24. Habib SH, Makpol S, Abdul HN, Das S, Ngah WZ, Yusof YA:
Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory
effects on ethionine-induced hepatoma rats. Clinics 2008,
63(6):807–813.
- 25. Vijaya PV, Arul DCS, Ramkuma KM: Induction of apoptosis by
ginger in HEp-2 cell line is mediated by reactive oxygen species.
Basic Clin. Pharmacol. Toxicol. 2007, 100(5):302–307.
- 26. Weng CJ, Wu CF, Huang HW, Ho CT, Yen GC: Anti-invasion
effects of 6-shogaol and 6-gingerol, two active components in ginger,
on human hepatocarcinoma cells. Mol. Nutr. Food Res. 2010,
54(11):1618–1627.
- 27. Yusof YAM, Ahmad N, Das S, Sulaiman S, Murad NA: Chemopreventive
efficacy of ginger (Zingiber officinale) in ethionine induced
rat hepatocarcinogenesis. African Journal of Traditional, Complementary
and Alternative Medicines 2009, 6(1):87-93.
- 28. Akimoto M, Iizuka M, Kanematsu R, Yoshida M, Takenaga K:
Anticancer effect of ginger extract against pancreatic cancer cells
mainly through reactive oxygen Species-mediated autotic cell death.
Plos One 2015, 10(5):1-22.
- 29. Karna P, Chagani S, Gundala SR, Rida PCG, Asif G, Sharma V,
Gupta MV, Aneja R: Benefits of whole ginger extract in prostate
cancer. Br J Nutr 2012, 107(4):473–484.
- 30. Elkady AI, Abuzinadah OA, Baeshen NA, Rahmy TR: Differential
control of growth, apoptotic activity, and gene expression in human
breast cancer cells by extracts derived from medicinal herbs Zingiber
officinale. Journal of Biomedicine and Biotechnology 2012,1-
- 31. Ray A, Vasudevan S, Sengupta S: 6-Shogaol inhibits breast cancer
cells and stem cell-like spheroids by modulation of Notch Signaling
Pathway and induction of autophagic cell death. PLoSONE 2015,
10(9):1-22.
- 32. Rastogi N, Duggal S, Singh SK, Porwal K, Srivastava VK, Maurya
R, Bhatt MLB, Mishra DP: Proteasome inhibition mediates p53
reactivation and anticancer activity of 6-Gingerol in cervical cancer
cell. Onkotarget 2015, 6(41):43310-25.
- 33. Rhode J, Fogoros S, Zick S, Wahl H, Griffith KA, Huang J, Liu JR:
Ginger inhibits cell growth and modulates angiogenic factors in ovarian
cancer cells. BMC Complementary and Alternative Medicine
2007, 7(44):1-9.
- 34. Cheng Yao C, Oh JH, Oh IG, Park CH, Chung JH: [6]-Shogaol
inhibits melanogenesis in B16 mouse melanoma cells through
activation of the ERK pathway. Acta Pharmacologica Sinica 2013,
34 (2013):289–294.
- 35. Huang HC, Chang SJ, Wu CY, Ke HJ, Chang TM: [6]-Shogaol
Inhibits 𝛼-MSH-Induced Melanogenesis through the acceleration of
ERK and PI3K/Akt-mediated MITF degradation. BioMed Research
International 2014, 1-9.
- 36. Liu Q, Peng YB, Zhou P, Qi LW, Zhang M, Gao N, Liu EH, Li P:
6-Shogaol induces apoptosis in human leukemia cells through a
process involving caspase-mediated cleavage of eIF2α. Molecular
Cancer 2013, 12(135):1-12.
- 37. Lee DH, Kimb DV, Jungc CH, Leea YJ, Parkd D: Gingerol sensitizes
TRAIL-induced apoptotic cell death of glioblastoma cells. Toxicol
Appl Pharmacol 2014, 279(3): 253–265.
- 38. Liu Y, Whelan RJ, Pattnaik BR, Ludwig K, Subudhi E, Rowland H,
Claussen N, Zucker N, Uppal S, Kushner DM, Felder M, Patankar
MS, Kapur A: Terpenoids from Zingiber officinale (Ginger) induce
apoptosis in endometrial cancer cells through the activation of p53.
PLoS ONE 2012, 7(12):1-10.
- 39. Rahman S, Salehin F, Asif I: In vitro antioxidant and anticancer
activity of young Zingiber officinale against human breast carcinoma
cell lines. BMC Complementary and Alternative Medicine 2011,
11(76):1-7.