Arnebia Forssk. Türlerinin Kullanışları ve Biyolojik Aktiviteleri

Year 2012, Issue: 1, 91 - 106, 01.01.2012

Merve Yüzbaşıoğlu Ayşe Kuruüzüm-uz

Abstract

Boraginaceae familyasında yer alan Arnebia Forssk. cinsi ülkemizde biri endemik 5 tür ile temsil edilmektedir. Halk arasında eyilik otu, kırmızı kök, eğnik, enlik, havaciva olarak da bilinmektedirler. Çalışmamızda, Arnebia türlerinin ve bu türlerden elde edilen bileşiklerin daha önce yapılan çalışmalarda belirtilen antitümoral, antienflamatuvar, prostaglandin sentez inhibitörü, antimikrobiyal, antiviral, platelet agregasyonunu inhibe edici, yara iyi edici ve kontraseptif etkileri derlenmiştir.

Keywords

Arnebia Forssk., Boraginaceae, Biyolojik Aktivite, Naftokinonlar

Usage and Biological Activities of Arnebia Forssk. species

Abstract

The genus Arnebia, which belongs to Boraginaceae is represented by 5 species in Turkey as well as one of them is an endemic plant. The roots of this plant were known as “eyilik otu, kırmızı kök, eğnik, enlik, havaciva” in Turkey. In our study; antitumoral, antiinflammatory, prostaglandin synthesis inhibitory, antimicrobial, antiviral, platelet agregation inhibitory, wound healing and contraceptive effects indicated in the previous studies of Arnebia species and compounds isolated from this species have been compiled.

Keywords

Arnebia Forssk., Boraginaceae, Biological Activity, Naphthoquinones

References

• Edmondson, J.R., “Arnebia Forssk.” P. H. Davis (Ed.). Flora of Turkey and the Aegean Islands, Edinburgh, Edinburgh University Press, (1978), Cilt VI.
• Sümbül, S.E.H., “Arnebia purpurea” P. H. Davis, Mill R.R. ve Tan K (Eds.). Flora of Tur- key and the East Aegean Islands, Edinburgh, Edinburgh University Press, (1988), Cilt X.
• Baytop, T. Türkiye’de Bitkiler ile Tedavi (Geçmişte ve Bugün), (2. bs), İstanbul, Nobel Tıp Kitap Evleri, (1999).
• Baytop, T., Türkçe Bitki Adları Sözlüğü, Ankara, Atatürk Kültür, Dil Ve Tarih Yüksek Kurumu, (1994).
• Shen, C.C., Syu, W.J., Li, S.Y., Lin, C.H., Lee, G.H.,Sun, C.M.: Antimicrobial activities of naphthazarins from Arnebia euchroma, J. Nat. Prod., 65 (12), 1857-1862, (2002).
• Salim, M.L., Ammar, H.A.,Oriquat, G.A.: Isolation and structure elucidation of 3,6-di- hydroxy-2-isovaleryl-1,4 benzoquinone from the roots of Arnebia decumbens (Boragi- naceae), Bull Fac Sci Cairo Univ, 34, 231-234, (1996)
• Ramachandrum, R., Ali, M.,Mir, S.R.: Andromedane-type derivatives from roots of Ar- nebia nobilis, Orient J Chem, 23, 533-540, (2007).
• Xu, X., Wang, B., Sun, Z., Zhang, J., Zhang, H.: Chemical constituents from root of Arnebia euchroma (Royle) Johnst., Jilin Daxue Xuebao, 48 319-322 (2010).
• Jain, S.C., Jain, R., Singh, B.: Antimicrobial principles from Arnebia hispidissima, Pharm Biol, 41, 231-233, (2003)
• Hamdard, M.E., Badar, Y., Khan, M.S., Shamsi, M.A.: Revised phytochemical study of Arnebia hispidissima, Pak J Pharm Sci, 1988; 1:19-20. Ref: C.A. 109:146300 (1988).
• Sezik, E., Tabata, M., Yesilada, E., Honda, G., Goto, K.,Ikeshiro, Y.: Traditional Medi- cine in Turkey .1. Folk Medicine in Northeast Anatolia., J. Ethnopharmacol, 35(2), 191- 196, (1991).
• Sezik, E., Yesilada, E., Tabata, M., Honda, G., Takaishi, Y., Fujita, T. ve diğerleri: Tra- ditional medicine in Turkey .8. Folk medicine in east Anatolia; Erzurum, Erzincan, Agri, Kars, Igdir provinces, Econ. Bot, 51(3), 195-211, (1997).
• Khatoon, S., Mehrotra, B.N.,Mehrotra, S.: Pharmacognostic evaluation of ratanjot- Arnebia nobilis Rech. F., Natural Product Sciences, 9 (4), 286-290 (2003).. Ref: C.A. 140:258797 (2004).
• Singh, H.: Importance of local names of some useful plants in ethnobotanical study, Indian J. Tradit. Know., 7(2), 365-370, (2008).
• Kunwar, R., Nepal, B., Kshhetri, H., Rai, S.,Bussmann, R.: Ethnomedicine in Himala- ya: a case study from Dolpa, Humla, Jumla and Mustang districts of Nepal. J. Ethno- biology Ethnomedicine, 2(1), 27, (2006).
• Kashiwada, Y., Bastow, K.F.,Lee, K.-H.: Novel lignan derivatives as selective inhibitors of DNA topoisomerase II, Bioorg. Med. Chem. Lett., 5(8), 905-908, (1995).
• Cui, X.-R., Tsukada, M., Suzuki, N., Shimamura, T., Gao, L., Koyanagi, J. ve diğerleri: Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones, Eur. J. Med. Chem., 43(6), 1206-1215, (2008).
• Xiong, W., Luo, G., Zhou, L., Zeng, Y., Yang, W.: In vitro and in vivo antitumor effects of acetylshikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspen- sion cultures, Chin. Med., 4, 14, (2009).
• Wassel, G., El-Menshawi, B., Saeed, A., Mahran, G.,El-Merzabani, M.: Screening of se- lected plants for pyrrolizidine alkaloids and antitumor activity, Pharmazie, 42(10), 709, (1987).
• Gupta, S.K., Mathur, I.S.: Effect of Arnebia nobilis and its naphthoquinones in rat walker carcinosarcoma 256, Indian J. Cancer, 9(1), 50-55 (1972).
• Li, Q., Chen, H., Lian, Y., Tian, C., Wang, X., Zhang, B., Zheng, Q.: Zhongguo Yiyuan Yaoxue 31(10), 829-832 (2011). Ref. AN. 2011:259553.
• Yüzbaşıoğlu, M.: Arnebia purpurea S. Erik & H. Sümbül Üzerinde Farmakognozik Araştırmalar, Yüksek Lisans Tezi, Hacettepe Üniversitesi, Ankara, (2010).
• Maierdan, M., Xu, J.,Gulixian, H.: Anti-aging effects of Arnebia euchroma (Royle) John- ston extracts in subacute aging mice caused by D-galactose, Xinjiang Yike Daxue Xue- bao, 32 (4), 383-386, (2009).
• Lin, Z. B., Chai, B. L., Wang, P., Guo, Q. X., Lu, F. S.,Xiang, G.-Q.: Studies on the an- tiinflammatory effect of chemical principle of Zi-Cao [Arnebia euchroma (Royle) John- st., Pei-ching I Hsueh Yuan Hsueh Pao, 12 (2), 101-106, (1980). Ref: C.A. 93:143008 (1980).
• Kaith, B.S., Kaith, N.S.,Chauhan, N.S.: Anti-inflammatory effect of Arnebia euchroma root extracts in rats, J. Ethnopharmacol., 55 (1), 77-80, (1996)
• Singh, B., Sharma, M.K., Meghwal, P.R., Sahu, P.M.,Singh, S.: Anti-inflammatory ac- tivity of shikonin derivatives from Arnebia hispidissima, Phytomedicine, 10(5), 375-380, (2003).
• Singh, B., Sahu, P.M., Jain, S.C., Singh, S.: Estimation of naphthaquinones from Ar nebia hispidissima (Lehm.) DC. in vivo and in vitro antiinflammatory screening, Phyto theraphy Research, 18(2), 154-159, (2004).
• Yao, X.S., Ebizuka, Y., Noguchi, H., Kiuchi, F., Iitaka, Y., Sankawa, U. ve diğerleri: Pros- taglandin biosynthesis inhibitors of Nan-shikon, the root of Arnebia euchroma, Tennen Yuki Kagobutsu Toronkai Koen Yoshishu, 26, 134-141, (1983).
• Yao, X.S., Ebizuka, Y., Noguchi, H., Kiuchi, F., Litaka, Y., Sankawa, U. ve diğerleri: Structure of arnebinol, a new ansa-type monoterpenylbenzenoid with inhibitory effect on prostaglandin biosynthesis, Tetrahedron Lett., 24(23), 2407-2410, (1983).
• Chang, Y.S., Kuo, S.C., Weng, S.H., Jan, S.C., Ko, F.N.,Teng, C.M.: Inhibition of platelet aggregation by shikonin derivatives isolated from Arnebia euchroma, Planta Med., 59(5), 401-404, (1993).
• Kosger, H.H., Ozturk, M., Sokmen, A., Bulut, E.,Ay, S.: Wound healing effects of Ar nebia densiflora root extracts on rat palatal mucosa, Eur. J. Dent., 3(2), 96-99, (2009).
• Akkol E., Koca, U., Pesin, I., Yılmazer, D., Toker, G.,Yesilada, E.: Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models, J. Ethnophar- macol., 124(1), 137-141, (2009).
• Sidhu, G.S., Singh, A.K., Banaudha, K.K., Gaddipati, J.P., Patnaik, G.K., Maheshwari, R.K.: Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound heal- ing, J. Invest. Dermatol., 113(5), 773-781, (1999).
• Jain, S.C., Jain, R., Singh, B.: Antimicrobial principles from Arnebia hispidissima, Pharm. Biol., 41(4), 231-233, (2003).
• Al-Mussawi, Abdulameer A.: Isolation and identification of Shikonin from Arnebia de cumbens L. and its antibacterial activity, Journal of Applied Sciences Research, 6(9), 1456 (2010). Ref. CA.154:279313 (2010).
• Kashiwada, Y., Nishizawa, M., Yamagishi, T., Tanaka, T., Nonaka, G., Cosentino, L.M. ve diğerleri: Anti-AIDS agents, 18. Sodium and potassium salts of caffeic acid tetra- mers from Arnebia euchroma as anti-HIV agents, J. Nat. Prod, 58(3), 392-400 (1995).
• Deng, Y., Wang, H., Han, L.: Isolation, purification and biological activities of Arnebia euchroma glycosaminoglycans, Zhongyaocai, 31(5), 753-756 (2008).
• Zhen, H., Liao, M., Xuan, L.,Guo, J.: Contraceptive constituent from Arnebia euchroma (Royle) Johnst. Tianran Chanwu Yanjiu Yu Kaifa, 14(1), 1-4. (2002). Ref. CA.137:152314 (2002).
• Tang, D., Yan, F., Xu, Y., Zheng, Y.: Effect of Arnebia euchroma glycosaminoglycans on steroidogenesis of cultured granulosa cells from rat in vitro, Nanchang Daxue Xuebao 50(5), 1-4, (2010). Ref. CA.155:83886 (2010).
• Orhan, I., Senol, F. S., Koca, U., Ercetin, T., Toker, G.: Evaluation of the antioxidant and acetylcholinesterase inhibitory activities of Arnebia densiflora Ledeb., Turk. J. Biol, 35(1), 111-115 (2011).
• Li, Q., Chen, H., Lian, Y., Tian, C., Wang, X., Zhang, B., Zheng, Q.: Effects of polysac- charides from Arnebia euchroma L. on immune functions of mice, Zhongguo Yiyuan Yaoxue Zazhi, 31(10), 829-832 (2011). Ref. AN 2011:1047947.
• Dai, B., Zhou, X., Yin, A., Pan, Y, Zou, S.: Determination of shikonin content in Ar- nebia euchroma extracts from four kinds of solvent systems and experimental observa- tion on its acute toxicity, Zhongguo Zhongyiyao Keji, 12(3), 168-169 (2005). Ref: C.A. 146:344647 (2006).
• Wassel, G., El-Menshawi, B., Saeed, A.,Mahran, G.: Toxic pyrrolizidine alkaloids of certain boraginaceous plants, Acta Pharmaceutica Suec., 24(4), 199-204 (1987).