Kendiliğinden Emülsifiye Olabilen İlaç Taşıyıcı Sistemler ve Farmasötik Alanda Uygulamaları

Year 2011, Issue: 2, 151 - 170, 01.06.2011

R. Neslihan Gürsoy , Özge Çevik

Abstract

İçeriğinde yağ, sürfaktan ve yardımcı çözücü/yardımcı sürfaktan bulunan izotropik sistemler olan SEDDS’ler Self-Emulsifying Drug Delivery Systems, SEDDS ilaç taşınımı, suda az çözünen ilaçların biyoyararlanımlarının artırılması ve lenfatik hedeflendirme gibi amaçlarla kullanılmaktadır. SEDDS’ler üçgen faz diyagramları ve yüksek verimli görüntüleme sistemleri yardımı ile özgün bileşimlerde hazırlanmaktadırlar. Çeşitli farmakolojik aktivitelere sahip düşük çözünürlükte ilaçlar ve peptit/ protein yapılı maddeler SEDDS’ler içine hapsedilebilmektedir. Bu yolla oral yolla verilmesi sorunlu olan maddelerin oral kullanımı mümkün olabilmektedir. SEDDS’ler ile formüle edilen ve oral biyoyararlanımı artırılan ilaçlardan olan Sandimmune Neoral® Siklosporin A , Norvir® Ritonavir ve Fortovase® Saquinavir günümüzde piyasada bulunmaktadır. Sıvı SEDDS formülasyonlarının sert veya yumuşak jelatin kapsüllere doldurulması ve püskürterek kurutma ile katı SEDDS’lerin hazırlanması sonucu daha yüksek mikrobiyolojik dayanıklılığa sahip formülasyonlar hazırlanmaktadır. SEDDS’lere olan ilginin artması ile birçok ilacın piyasaya kazandırılması veya daha etkin bir şekilde düşük doz, oral kullanımın sağlanması vb. kullanılabilmesi mümkün olabilecektir.

Keywords

Kendiliğinden emülsifiye olabilen ilaç taşıyıcı sistemler SEDDS, çözünürlük, biyoyararlanım, oral uygulama, sıvı ve katı SEDDS

Self - Emulsifying Drug Delivery Systems and their Pharmaceutical Applications

Abstract

Self emulsifying drug delivery systems SEDDS are isotropic mixtures which contain surfactant, oil and cosolvents and they are used for drug delivery, enhanced bioavailability of poorly soluble drugs and lymphatic drug targeting. SEDDS are prepared using ternary phase diagrams and high throughput screening systems with spesific ratios of excipients. Various poorly soluble drugs which have different pharmacological activities and peptide/protein drugs can be entrapped in SEDDS. By this way, drugs which have solubility or stability problems can be formulated with SEDDS and oral route could be possible for administration. Sandimmune Neoral® Cyclosporine A , Norvir® Ritonavir and Fortovase® Saquinavir are products on the pharmaceutical market which are formulated with SEDDS formulations and have improved oral bioavailability. Liquid SEDDS formulations can be filled into hard or soft gelatine capsules and solid SEDDS can be prepared by spray drying which have more microbiological stability. Because of increased interest in SEDDS, new drug compounds can be formulated and marketed or they can be used more efficiently like lower dose, enhanced stability or oral administration.

Keywords

Self emulsifying drug delivery systems SEDDS, solubility, bioavailability, oral administration, liquid and solid SEDDS

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