Year 2006,
Issue: 2, 77 - 86, 01.06.2006
Abstract
V. chionophyllum, V. cilicicum, V. pterocalycinum var. mutense, V. pycnostachycum ve V. splendidum Scrophulariaceae ’un, SK-MEL, KB, BT-549 ve SK-OV-3 kanser hücrelerine karşı sitotoksik aktiviteleri çalışılmıştır. Sonuçlar, bu türlerin metanol ve etil asetat ekstrelerinin sitotoksik aktiviteleri karşılaştırılarak değerlendirilmiştir. V. pterocalycinum var. mutense çiçeklerinin metanol ekstresi, SK-MEL kanser hücresine karşı zayıf sitotoksik aktivite göstermiştir. Bu türün metanol ekstresi üzerinde yapılan biyolojik rehberli fraksiyonlama ile yedi fraksiyon elde edilmiş, ancak, fraksiyonların hiçbirisi sitotoksik aktivite göstermemiştir.
References
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- Itokawa, H., Takeya, K., Mori, N., Sonobe, T., Mihashi, S., Hamanaka, T.: Studies on antitumor cyclic hexapeptides Ra obtained from Rubia Radix, Rubiaceae. 6. Minor an- titumor constituents. Chem. Pharm. Bull., 34, 3762 (1986).
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Year 2006,
Issue: 2, 77 - 86, 01.06.2006
Abstract
V. chionophyllum, V. cilicicum, V. pterocalycinum var. mutense, V. pycnostachycum and V. splendidum Scrophulariaceae were studied for their cytotoxic activities against SK-MEL, KB, BT-549, and SK-OV-3 cell lines. The results were evaluated to compare cytotoxic activity in both their methanol and ethylacetate extracts. The methanol extract of the flowers of V. pterocalycinum var. mutense showed a weak cytotoxic activity against SK-MEL cell line. Through bioassay-guided fractionation on the methanol extract of this species, seven fractions were obtained; however, none of the fractions had cytotoxic activity against cancer cell lines.
References
- Lee, K. H.: Novel antitumor agents from higher plants, Medicinal Research Reviews, 19 (6), 569-596 (1999).
- Huber-Morath, A. Verbascum, in “Flora of Turkey and the East Aegean Islands” (edited by P.H. Davis), Edinburgh, University Press, Vol. 6, 461 (1978).
- Baytop, T.: Therapy with Medicinal Plants in Turkey (Past and Present), Istanbul, Nobel Tıp Kitabevleri Ltd., 2nd ed., 334 (1999).
- Ucar-Turker, A., Camper, N.D.: Biological activity of common mullein, a medicinal plant, J. Ethnopharmacol., 82, 117 (2002).
- Ionkova, I., Alferman, A.: Use of DNA for detection and isolation of potential anticancer agents from plants. Farmatsiya, 47, 10 (2000).
- Itokawa, H., Takeya, K.: Antitumor sunstances from higher plants. Heterocycles, 35, 1467 (1993).
- Borenfreund, E., Babich, H., Martin-Alguacil, N.: Rapid chemosensitivity assay with human normal and tumor cells in vitro, In Vitro Cell. Dev. Biol., 26, 1030 (1990).
- Dou, J., McChesney, J.D., Sindelar, R.D., Goins, D.K., walker, L.A.: A new quassinoid from Castela texana, J. Nat. Prod., 59, 73 (1996).
- Muhammad, I., Dunbar, D.C., Khan, R.A., Ganzera, M., Khan, I.A.: Investigation of Una De Gato I. 7-deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa, Phytochemistry, 57, 781 (2001).
- Muhammad, I., Bedir, E., Khan, S.I., Tekwani, B.L., Khan, I.A., Takamatsu, S., Pel- letier, J., walker, L.A.: A new antimalarial quassinoid from Simaba orinocensis, J. Nat. Prod., 67, 772 (2004).
- Afifi, M.S.A., Ahmed, M.M., Pezzuto, J.M., Kinghorn, A.D.: Cytotoxic flavonolignans and flavones from Verbascum sinaiticum leaves, Phytochemistry, 34, 839 (1993).
- Klimek, B., Stepien, H.: Effect on some constituents of mullein (Verbascum sp.) on proliferation of rat splenocytes in vitro, Eur. J. Pharm. Sci., 2 (1-2), 123 (1994).
- Paszkiewicz-Gadek, A., Grochowska, K., Galasinski, w.: Effect of the aqueous extract and saponin fraction from the flowers of Verbascum thapsiforme on protein biosynthe- sis in a rat liver ribosomal system, Phytother. Res., 4, 177 (1990).
- Lin, L.T., Liu, L.T., Chiang, L. C., Lin, Cc.: In vitro Anti-hepatoma Activity of Fifteen Natural Medicines from Canada, Phytother. Res., 16, 440 (2002).
- Itokawa, H., Takeya, K., Mori, N., Sonobe, T., Mihashi, S., Hamanaka, T.: Studies on antitumor cyclic hexapeptides Ra obtained from Rubia Radix, Rubiaceae. 6. Minor an- titumor constituents. Chem. Pharm. Bull., 34, 3762 (1986).
- Saracoglu, I., Inoue, M., Calis, I., Ogihara, Y.: Studies on constituents with cytotoxic and cytostatic activity of two Turkish medicinal plants, Phlomis armeniaca and Scutel- laria salviifolia. Biol. Pharm. Bull., 18, 1396 (1995).
There are 16 citations in total.
Details
| Primary Language | English |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2006 |
| Published in Issue | Year 2006 Issue: 2 |