Development and evaluation of buspirone hyrdochloride loaded transdermal patch using natural polymers

Year 2023, Volume: 43 Issue: 4, 310 - 322, 01.12.2023

Komal Parmar Meshva Patel , Mehul Patel , Tejal Soni , Dr. Bhanubhai Suhagia

https://doi.org/10.52794/hujpharm.1214109

Abstract

The purpose of this present study was to design and develop a Buspirone hydrochloride loaded matrix type transdermal drug delivery system (TDDS) with four natural gum polymers such as Guar gum, Gellan gum, Xanthan gum, Karaya gum. A total of twelve batch of matrix patches were formulated with above stated polymers and other excipient like Glycerin, Propylene glycol (PG), Polyethylene glycol (PEG) as plasticizer. These all batches were characterized by evaluation parameters which including drug content, flatness, thickness, uniformity of weight, folding endurance, moisture content, moisture uptake and to determine the amount of Buspirone hydrochloride present in the matrix of patches in vitro dissolution study of all twelve formulations were performed. Fourier transform infrared (FTIR) technique and Differential Scanning Colorimetry (DSC) carried out to determine interaction between Buspirone HCl and excipients which are present in patch. Permeation study of patch of Buspirone HCl was performed in Franz's diffusion cell to evaluate In-vitro skin permeation and it was found that batch G3 shows 98.89% permeability. After evaluating all batches and based on results which are obtained characterization and In-Vitro dissolution it was concluded that patches containing natural polymers are not showing any interaction and better release study.

Keywords

Transdermal Drug Delivery, Buspirone hydrochloride, Guar gum, Gellan gum, Xanthan gum

Supporting Institution

Dharmsinh Desai University, Faculty of pharmacy, Nadiad

References

• 1. Bhatia C, Sachdeva M, Bajpai M. Formulation and evaluation of transdermal patch of pregabalin. International Journal of Pharmaceutical Sciences and Research. 2012;3(2):569. http:// dx.doi.org/10.13040/IJPSR.0975-8232.3(2).569-75
• 2. Jain NK. Controlled and novel drug delivery. CBS publishers & distributors New Delhi; 1997.
• 3. Fox LM. Remington: the science and practice of pharmacy. American Journal of Pharmaceutical Education. 2006;70(3):X3.
• 4. Troy DB. Remington: The science and practice of pharmacy. (No Title). 2005;
• 5. Zhang Y, Cun D, Kong X, Fang L. Design and evaluation of a novel transdermal patch containing diclofenac and teriflunomide for rheumatoid arthritis therapy. Asian Journal of pharmaceutical sciences. 2014;9(5):251–9. http://doi. org/10.1016/j.ajps.2014.07.007
• 6. Jamakandi VG, Mulla JS, Vinay BL, Shivkumar HN. Formulation, Characterisation, and Evaluation of matix type transdermal patches of Anti-hypertensive Drugs. Drug Del. 2009;1–7. http://doi.org/10.4103/0973-8398.49177
• 7. Tyagi RK, Chandra A, Singh D, Rahman MA. Transdermal drug delivery system (TDDS): an overview. International journal of pharmaceutical sciences and research. 2011;2(6):1379. http://dx.doi.org/10.13040/IJPSR.0975-8232.2(6).1379-88
• 8. Garala KC, Shinde AJ, Shah PH. Formulation and in-vitro characterization of monolithic matrix transdermal systems using HPMC/Eudragit S 100 polymer blends. Int J Pharm Pharm Sci. 2009;1(1):108–20.
• 9. Patel H, Panchal DR, Patel U, Brahmbhatt T, Suthar M. Matrix type drug delivery system: A review. J Pharm Sci Biosci Res. 2011;1(3):143–51.
• 10. Kulkarni Vishakha S, Butte Kishor D, Rathod Sudha S. Natural polymers–A comprehensive review. International journal of research in pharmaceutical and biomedical sciences. 2012;3(4):1597–613.
• 11. Patel H, Patel U, BHIMANI B, DASLANIYA D. Transdermal drug delivery system as prominent dosage forms for the highly lipophilic drugs. The International Journal of Pharmaceutical Research and Bio-Science. 2012;1(3).
• 12. George A, Shah PA, Shrivastav PS. Guar gum: Versatile natural polymer for drug delivery applications. European Polymer Journal. 2019;112:722–35. http://doi.org/10.1016/j.eurpolymj. 2018.10.042
• 13.Bharti K, Mittal P, Mishra B. Formulation and characterization of fast dissolving oral films containing buspirone hydrochloride nanoparticles using design of experiment. Journal of Drug Delivery Science and Technology. 2019;49:420–32. 10.1016/J. JDDST.2018.12.013
• 14.Nagaich U, Chaudhary V, Nagaich J. Development and Statistical Optimisation of Buspirone Hydrochloride Buccoadhesive Films. International Scholarly Research Notices. 2014;2014. http://dx.doi.org/10.1155/2014/214026
• 15. Dhandapani H, Hemamrutha S, Lakshmi Sravanthi K, Swetha J. Spectrophotometric estimation of buspirone hydrochloride in bulk and its pharmaceutical formulation. Int J of Pharma Sciences and Research. 2010;1(4).
• 16. Joshi GV, Kevadiya BD, Bajaj HC. Design and evaluation of controlled drug delivery system of buspirone using inorganic layered clay mineral. Microporous and Mesoporous Materials. 2010;132(3):526–30.
• 17. Takka S, Sakr A, Goldberg A. Development and validation of an in vitro–in vivo correlation for buspirone hydrochloride extended release tablets. Journal of controlled release. 2003;88(1):147–57. https://doi.org/10.1016/S0168- 3659(02)00490-X
• 18. Sheikhzadeh M, Rohani S, Jutan A, Manifar T, Murthy K, Horne S. Solid-state characterization of buspirone hydrochloride polymorphs. Pharmaceutical research. 2006;23:1043–50. https://doi.org/10.1007/s11095-006-9779-6
• 19. Saxena M, Mutalik S, Reddy MS. Formulation and evaluation of transdermal patches of metoclopramide hydrochloride. Indian drugs. 2006;43(9):740–5.
• 20. Dhamecha DL, Rathi AA, Saifee M, Lahoti SR, Dehghan MHG. Drug vehicle based approaches of penetration enhancement. Int J Pharm Pharm Sci. 2009;1(1):24–46.
• 21. Bharkatiya M, Nema RK, Bhatnagar M. Development and characterization of transdermal patches of metoprolol tartrate. Asian J Pharm Clin Res. 2010;3(2):130–4.
• 22. Mahajan NM, Zode GH, Mahapatra DK, Thakre S, Dumore N, Gangane PS. Formulation development and evaluation of transdermal patch of piroxicam for treating dysmenorrhoea. Journal of Applied Pharmaceutical Science. 2018;8(11):035– 41. 10.7324/JAPS.2018.81105
• 23. Darwhekar G, Jain DK, Patidar VK. Formulation and evaluation of transdermal drug delivery system of clopidogrel bisulfate. Asian J Pharm Life Sci ISSN. 2011;2231:4423.
• 24. Dahodwala STS, Sheikh A. Formulation and evaluation of transdermal film of promethazine hydrochloride. Journal of Advanced Pharmacy Education & Research Oct-Dec. 2013;3(4). https://doi.org/10.4103/2230-973X.176468
• 25. Sathyapriya LS, Jayaprakash S, Prabhu RS, Abirami A, Subramanian K, Nagarajan M. An approach to the formulation and evaluation of transdermal DDS of isoxsuprine HCL. Int J Pharm Sci Tech. 2008;1:22–8.
• 26. Bangale GS, Rathinaraj BS, Rajesh KS, Shinde GV, Umalkar DG, Rajveer CH, et al. Design and evaluation of transdermal films of Atenolol. J Chem Pharm Res. 2010;2(3):593–604.
• 27. Allena RT, Yadav HK, Sandina S, Sarat Chandra Prasad M. Preparation and evaluation of transdermal patches of metformin hydrochloride using natural polymer for sustained release. Int J Pharm Pharm Sci. 2012;4(3):297–305.
• 28. Sheth NS, Mistry RB. Formulation and evaluation of transdermal patches and to study permeation enhancement effect of eugenol. Journal of Applied Pharmaceutical Science. 2011;(Issue): 96–101.