Migren Araştırmalarında Kullanılan Güncel Hayvan Modelleri

Year 2023, Volume: 43 Issue: 4, 364 - 379, 01.12.2023

Melih Zeki Kaya , Sibel Bozdağ Pehlivan , Levent Öner

https://doi.org/10.52794/hujpharm.1332342

Abstract

Hayvan modelleri, insana zarar verme riski olmadan insanda görülen hastalıkların incelenmesinde ve yeni terapötik yaklaşımların geliştirilmesinde kullanılan önemli araştırma araçlarıdır. Hayvan modellerinde gözlenen biyolojik aktivite ile insanda elde edilen arasında her zaman birebir benzerlik olmasa da insan hastalıkları için birçok ilaç ve tedavi hayvan modellerinin rehberliğinde geliştirilmektedir. Bu kapsamda, son yıllarda baş ağrısı ve migren mekanizmalarını incelemek için hayvan modelleri yoğun bir şekilde geliştirilmiş ve bunun sonucu olarak migrenin anlaşılmasında ve anti migren tedavilerin geliştirilmesinde önemli adımlar atılmıştır. Bu modeller arasında, genetik modifikasyonlarla oluşturulan fare ve sıçan modelleri, trigeminal sinir sistemi aktivasyonunu taklit eden modeller ve inflamatuar ajanlarla baş ağrısı indüklenen modeller yer almaktadır. Her bir modelin kendine özgü üstünlük ve sınırlaması olduğundan, ilaç etkinliğini değerlendirmek için uygun hayvan modelinin seçimi ve sonuçların değerlendirilmesi için en uygun deneysel yöntemin seçimi kritik bir parametredir. Bu derlemede son yıllarda üzerinde yoğun bir biçimde çalışılan in-vivo migren modelleri ve bu modellerden elde edilen en son bulgular üzerinde tartışılacaktır

Keywords

Migren, Hayvan modelleri, Preklinik araştırmalar, Baş ağrısı, Nörobiyoloji

Supporting Institution

TÜBİTAK

Project Number

118C131

Thanks

Melih Zeki Kaya TÜBİTAK 2244 programı kapsamında 118C131 kodlu projede bursiyer olarak görev almıştır.

Current Animal Models Used in Migraine Research

Abstract

Animal models are important research tools used in the study of human diseases and in the development of new therapeutic approaches without the risk of harming humans. Although there is not always one-to-one similarity between the biological activity observed in animal models and that obtained in humans, many drugs and treatments for human diseases are developed under the guidance of animal models. In this context, animal models have been extensively developed in recent years to examine the mechanisms of headache and migraine, and as a result, important steps have been taken in the understanding of migraine and the development of anti-migraine treatments. These models include mouse and rat models created by genetic modifications, models that mimic trigeminal nervous system activation, and models that induce headaches with inflammatory agents. Since each model has its own advantages and limitations, the selection of the appropriate animal model to evaluate drug efficacy and the most appropriate experimental method to evaluate the results is a critical parameter. In this review, in-vivo migraine models that have been studied extensively in recent years and the latest findings from these models will be discussed.

Keywords

Migraine, Animal models, Preclinical studies, Headache, Neurobiology

Project Number

118C131

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