Kanser Tedavisinde Bakteri Destekli İlaç Taşıyıcı Sistemler

Year 2024, Volume: 44 Issue: 1, 75 - 91, 01.03.2024

Maide Öztürk , Sibel Bozdağ Pehlivan

https://doi.org/10.52794/hujpharm.1392635

Abstract

Kanser tedavisine yönelik terapötiklerin ve tedavi yaklaşımlarının geliştirilmesine rağmen hastalık dünya çapında önde gelen ölüm nedenlerinden biridir. Spesifite eksikliği, sitotoksisite ve çoklu ilaç direnci gibi sınırlamalar nedeniyle kemoterapi, radyasyon terapisi ve immünoterapi gibi kanser tedavileri ile henüz istenen düzeyde başarı elde edilememiştir. Bu nedenle yan etkilerin azaltılarak etkin bir tedavinin gerçekleştirilebilmesi için hedefe yönelik tedavilerin geliştirilmesi büyük önem taşımaktadır. Ancak kanser mikroçevresi, vaskülarizasyonu ve hipoksik bölgeleri ile hedeflendirme için birçok fizyolojik engele sahiptir. 1800’lü yıllardan günümüze kadar yapılan araştırmalar, bakterilerin bu fizyolojik engelleri aşarak kanser dokusuna seçici olduğunu göstermiştir. Bakterilerin doğal olarak tümör dokularını hedefleme ve dokuda birikme özelliklerine sahip olduğunun keşfedilmesiyle birlikte araştırmacılar, bakteri destekli ilaç taşıyıcı sistemler üzerine yoğunlaşmıştır. Bakterilerin hareketlilik, immün yanıt oluşturma ve kolay modifikasyon özelliğiyle konvansiyonel ilaç taşıyıcı sistemlerden daha üstün olduğu bildirilmiştir. Bu derlemede kanser tedavisine yönelik bakteri destekli ilaç taşıyıcı sistemler konusunda literatürde yer alan en güncel gelişmeler değerlendirilmiştir.

Keywords

İlaç taşıyıcı sistem, bakteri destekli ilaç taşıyıcı sistem, hedeflendirilmiş tedavi, nanoteknoloji, kanser tedavisi

Bacteria Mediated Drug Delivery System for Cancer Therapy

Abstract

Despite the development of therapeutics and treatment approaches for cancer treatment, the disease remains one of the leading causes of death worldwide. Due to limitations such as lack of specificity, cytotoxicity, and multidrug resistance, the desired level of success has not yet been achieved with cancer treatments such as chemotherapy, radiation therapy, and immunotherapy. Therefore, it is of great importance to develop targeted treatments to provide effective treatment by reducing side effects. However, the cancer microenvironment, with its vascularization and hypoxic regions, has many physiological obstacles to targeting. Research from the 1800s to the present has shown that bacteria are selective for cancer tissue by overcoming these physiological barriers. With the discovery that bacteria naturally can target and accumulate in tumor tissues, researchers have focused on bacteria mediated drug delivery systems. It has been reported that bacteria are superior to conventional drug carrier systems with their mobility, immune response, and easy modification properties. In this review, the most current developments in the literature on bacteria mediated drug delivery systems for cancer treatment are evaluated.

Keywords

Drug delivery system, bacteria mediated drug delivery system, targeted treatment, nanotechnology, cancer therapy

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