İlaç Geliştirme Uygulamalarında Click Kimyasının Kullanımı

Year 2024, Issue: Special Issue / International Multidisciplinary Symposium on Drug Research and Development, DRD-2023, 54 - 63, 01.07.2024

Beyza Düzleyen , Gülşah Karakaya , Mutlu Aytemir

https://doi.org/10.52794/hujpharm.1368714

Abstract

Click kimyası, heteroatom bağlantıları yoluyla küçük yapı taşlarını bir araya getiren güçlü, güvenilir ve seçici reaksiyonlar olarak tanımlanmaktadır. Click reaksiyonları, kimyasal dönüşümler için pratik ve uygun bir yaklaşım olan modüler bir stratejidir. Bu strateji, hafif reaksiyon koşulları, ara ürünlerin kolay saflaştırılması ve ilaç hedeflerinin görüntülenmesi gibi zorlu süreçler için umut verici bir yaklaşım olmuştur. Bu avantajlar, farmasötik bilimlerde ilaç keşfi ve geliştirilmesine yeni bir boyut kazandırmıştır. Klik reaksiyonları, günümüzde ilaç geliştirme çalışmaları, biyokonjugasyon, polimer ve malzeme kimyası, ilaç dağıtım sistemleri gibi alanlarda çalışılan ilginç reaksiyonlardır. Bu derlemede, biyouyumluluğu ve güvenilirliği nedeniyle click kimyasının altın standardı olarak kabul edilen bakır katalizli Huisgen 1,3-dipolar siklokatılma reaksiyonunun önemli noktaları ve seçici olarak oluşan 1,2,3-triazolün ilaç geliştirme çalışmalarında kullanımı tartışılmaktadır.

Keywords

bakır katalizi, ilaç tasarımı, biyokonjugasyon, triazol, 1,3-dipolarsikloadisyon

The Use of Click Chemistry in Drug Development Applications

Abstract

Click chemistry is defined as powerful, reliable and selective reactions that assemble small building blocks via heteroatom linkages. Click reactions are a modular strategy that is a practical and convenient approach to chemical transformations. This strategy has been a promising approach for challenging processes such as mild reaction conditions, easy purification of intermediates, and imaging of drug targets. These advantages have added a new dimension to drug discovery and development in pharmaceutical sciences. Click reactions are interesting reactions that are currently studied in drug development studies, bioconjugation, polymer and material chemistry, drug delivery systems. In this review, important highlights of the copper-catalysed Huisgen 1,3-dipolar cycloaddition reaction, which is recognised to be the gold standard of click chemistry because of its biocompatibility and reliability, and the use of the selectively formed 1,2,3-triazole in drug development studies are discussed.

Keywords

copper catalysis, triazole, drug design, bioconjugation, 1,3-dipolar cycloaddition

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