Evaluation of Complete Blood Count Parameters in Tubal Ectopic Pregnancy

Year 2020, Volume: 17 Issue: 1, 65 - 69, 29.04.2020

Gökçe Turan , Berna Aslan Çetin , Gözde Demirezen , Nurullah Peker

https://doi.org/10.35440/hutfd.661424

Cited By: 1

Abstract

Background: The aim of this study was to compare the hemogram parameters of patients with ectopic pregnancy (EP) and healthy intrauterine pregnancy.
Materials and Methods: Between January 2013 and January 2017, the demographic data of patients with first-trimester intrauterine pregnancy and patients with a diagnosis of tubal EP issue in a tertiary center, and white blood cell count (WBC), hemoglobin (Hgb), hematocrit (Hct), neutrophil and lymphocyte count, neutrophil-lymphocyte ratio (NLR), platelet count (PLT), platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) values on complete blood count were recorded and compared with each other.
Results: A total of 718 patients with ectopic pregnancies and 937 patients with healthy intrauterine pregnancies were included in the present study. Between groups, age, gravida, parity, and abortion in the group with EP (study group) were monitored significantly higher (p <0.001), the gestational week was found significantly higher in the control group (p <0.001). Hgb, Hct and MPV values of the groups were monitored significantly higher in the Control Group (p<0.001), and no significant differences were detected between the WBC, PLT, NLR and PLR values of both groups.
Conclusions: As a result, only the MPV value was found significant among the hemogram parameters in predicting ectopic pregnancy. In this study, NLR and PLR values were not found significant in the diagnosis of EP. Prospective studies with larger participants are needed to investigate more possible relationships with hemogram, NLR and PLR values in EP diagnosis and treatment protocols.

Keywords

Ectopic pregnancy, Mean platelet volume, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio

Tubal Ektopik Gebelik Tanısında Tam Kan Sayımı Parametrelerinin Değerlendirilmesi

Abstract

Amaç: Bu çalışmadaki amaç ektopik gebeliği (EG) olan hastalar ile sağlıklı intrauterin gebeliği olan hastaların hemogram parametrelerini karşılaştırmaktır.
Materyal ve Metod: Ocak 2013 ile Ocak 2017 tarihleri arasında tersiyer bir merkezde tubal EG tanısı konan hastalar ile ilk trimester intrauterin gebeliği olan hastaların demografik verileri ve tam kan sayımındaki beyaz küre (WBC), hemoglobin (Hgb), hematokrit (Hct), nötrofil, lenfosit, platelet (PLT), ortalama platelet hacmi (MPV), nötrofil-lenfosit oranı (NLO) ve platelet-lenfosit oranı (PLO) karşılaştırıldı.
Bulgular: EG’i olan 718 hasta ile sağlıklı intrauterin gebeliği olan 937 hasta çalışmaya dahil edildi. Yaş, gravida, parite ve abortus EG grubunda (çalışma grubu) anlamlı olarak daha yüksek izlenirken (p<0,001), gestasyonel hafta ise kontrol grubunda anlamlı olarak yüksek bulundu (p<0,001). Hgb, Hct ve MPV değerleri kontrol grubunda anlamlı olarak yüksek izlenirken (p<0,001), WBC, PLT, NLO ve PLO değerleri karşılaştırıldığında iki grup arasında anlamlı fark izlenmedi.
Sonuç: Sonuç olarak EG’i öngörmede hemogram parametrelerinden sadece MPV değeri anlamlı bulundu. Bu çalışmada NLO ve PLO değerleri EG tanısında anlamlı bulunmadı. EG tanı ve tedavi protokollerinde hemogram, NLO ve PLO değerleri daha olası ilişkileri araştırmak için daha geniş hasta gruplarının inceleneceği prospektif çalışmalara ihtiyaç vardır.

Keywords

Ektopik gebelik, Mean platelet volume, Nötrofil-lenfosit oranı, Platelet-lenfosit oranı

References

• 1. Yalçin Bahat P, Turan G, Aslan Çeti̇n B, Polat İ. Comparison of laparoscopy and laparotomy in surgical treatment of ectopic pregnancies: A 6-year experience at a tertiary center. Turkiye Klin Jinekoloji Obstet. 2018;28(2):60-64. doi:10.5336/jcog.2018-61559.
• 2. Bouyer J, Coste J, Shojaei T, Pouly JL, Fernandez H, Gerbaud L et al. Risk factors for ectopic pregnancy: A comprehensive analysis based on a large case-control, population-based study in France. Am J Epidemiol. 2003;157(3):185-194. doi:10.1093/aje/kwf190.
• 3. Shaw JLV, Dey SK, Critchley HOD, Horne AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update. 2010;16(4):432-444. doi:10.1093/humupd/dmp057.
• 4. Peker N, Yaman Tunç S, Sak S, Karaçor T, Başaranoğlu S, Gül T. Ektopik Gebelik Olgularında Gebelik Haftasına Göre Tedavi Yaklaşımlarının Retrospektif Değerlendirilmesi. Zeynep Kamil Tıp Bülteni. 2017;48(1). doi:10.16948/zktipb.263871.
• 5. Turgut A, Sak ME, Özler A, Soydinç HE, Karaçor T, Gül T. Alteration of peripheral blood cells in tubal ectopic pregnancy. Ginekol Pol. 2013;84(3):193-196. doi:10.17772/gp/1562.
• 6. Ulkumen BA, Pala HG, Calik E, Koltan SO. Can mean platelet volume and platelet distrubition width be possible markers for ectopic pregnancy and tubal rupture? (MPV and PDW in ectopic pregnancy). Pakistan J Med Sci. 2014;30(2):352-355. doi:10.12669/pjms.302.4177.
• 7. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: A simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28-32.
• 8. Li Z, Yang F, Dunn S, Gross AK, Smyth SS. Platelets as immune mediators: Their role in host defense responses and sepsis. Thromb Res. 2011;127(3):184-188. doi:10.1016/j.thromres.2010.10.010.
• 9. Practice Committee of the American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: a committee opinion. Fertil sterility,. 2013;100(3):638-644.
• 10. Stulberg DB, Cain LR, Dahlquist I, Lauderdale DS. Ectopic pregnancy rates in the Medicaid population. Am J Obstet Gynecol. 2013;208(4):274.e1-274.e7. doi:10.1016/j.ajog.2012.12.038.
• 11. Menon S, Colins J, Barnhart KT. Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review. Fertil Steril. 2007;87(3):481-484. doi:10.1016/j.fertnstert.2006.10.007.
• 12. Rausch ME, Barnhart KT. Serum biomarkers for detecting ectopic pregnancy. Clin Obstet Gynecol. 2012;55(2):418-423. doi:10.1097/GRF.0b013e31825109f6.
• 13. Mannaerts D, Heyvaert S, De Cordt C, Macken C, Loos C, Jacquemyn Y. Are neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and/or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia? J Matern Neonatal Med. 2019;32(9):1412-1419. doi:10.1080/14767058.2017.1410701.
• 14. Eskicioğlu F, Özdemir AT, Turan GA, Gür EB, Kasap E, Genç M. The efficacy of complete blood count parameters in the diagnosis of tubal ectopic pregnancy. Ginekol Pol. 2014;85(11):823-827. doi:10.17772/gp/1907.
• 15. Yuri Gasparyan A, Ayvazyan L, P. Mikhailidis D, D. Kitas G. Mean Platelet Volume: A Link Between Thrombosis and Inflammation? Curr Pharm Des. 2011;17(1):47-58. doi:10.2174/138161211795049804.
• 16. Kanmaz AG, Inan AH, Beyan E, Budak A. Role of various complete blood count parameters in predicting the success of single-dose methotrexate in treating ectopic pregnancy. Pakistan J Med Sci. 2018;34(5):1132-1136. doi:10.12669/pjms.345.15356.
• 17. Kan Ö, Gemici A, Alkilic A, Cetindag EN, Cakir C et al. The Effect of Preoperative Neutrophil-To-Lymphocyte Ratio and Platelet-To-Lymphocyte Ratio on Predicting Rupture Risk in Tubal Ectopic Pregnancies. Gynecol Obstet Invest. July 2019. doi:10.1159/000496543.