KARACİĞER BİYOPSİ İLE NONALKOLİK YAĞLI KARACİĞER HASTALIĞI TANISI ALAN 220 HASTANIN RETROSPEKTİF DEĞERLENDİRİLMESİ

Year 2020, Volume: 6 Issue: 1, 50 - 64, 30.01.2020

Alihan Oral , Tolga Şahin

Abstract

Non alkolik yağlı karaciğer hastalğı (NAYKH)
alkol tüketimi olmadan karaciğer yağlanması olarak tanımlanır. NAYKH, dünyada
en sık görülen kronik karaciğer hastalığı olarak bilinir. NAYKH, siroz ve
hepatoselüler kanser gibi ciddi hastalıklara sebep olabilmektedir. Bu çalışmada
karaciğer biyopsisi ile NAYKH tanısı alan 220 hastayı retrospektif
olarak değerlendirmeyi amaçladık. Araştırmaya 2010-2019 yılları arasında
Demiroğlu Bilim Üniversitesi Tıp Fakültesi gastroenteroloji polikliniğinde
takip edilen karaciğer biyopsi ile NAYKH tanısı alan toplam 220 hasta alındı.
Olguların demografik (yaş, cinsiyet, boy, kilo, beden kitle indeksi (BMI),
laboratuvar (biyokimyasal parametreler) ve biyopsi sonuçları hastane bilgi
sisteminden ve dosyalarından retrospektif olarak toplandı. Hastaların yaş ortalaması 34.14 ± 6.72 ve % 60’ı erkek, % 40’ı
kadındı. Erkek ve kadın hastalarda karaciğer yağlanma yüzdesi ortalaması
benzerdi (p: 0.41). Hastaların BMI ortalaması: 27.32 ± 3.02, ortalama karaciğer
steatoz yüzdesi % 12.1 ± 8.68 ve ortalama Homeostatic Model of Assessment-Insulin
Resistance (HOMA-IR) değeri 2.64 saptandı. Yağlanma derecesi ile BMI, aspartat
aminotransferaz, alanin aminotransferaz, alkalen fosfataz, gamaglutamil
transferaz, total kolesterol, trigliserit , kreatinin ve HOMA-IR arasında
pozitif korelasyon saptanırken yaş, üre ve total biluribin ile herhangi bir
korelasyon belirlenmedi. Çalışmamızda
genç ve orta yaş grubu ile obez olmayan kişilerde de NAYKH görülebileceği, BMI
ve insülin direncinin bu hasta grubunda da NAYKH ile ilişkili olabileceği gözlendi.
Ayrıca, karaciğer enzimleri normal aralıkta olsa bile NAYKH ile ilişkili
olabilecekleri görülmüştür. Yeni ve daha geniş kapsamlı çalışmalarla, bu konuda
daha güvenilir veriler elde edilebileceği düşünülmektedir.

Keywords

Karaciğer yağlanması, NAFLD, hepatosteatoz

RETROSPECTIVE EVALUATION OF 220 PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE DIAGNOSED BY LIVER BIOPSY

Abstract

Non-alcoholic fatty liver disease (NAFLD)
defined as fatty accumulation in liver without alcohol consumption. NAFLD is
known as the most common chronic liver disease worldwide. NAFLD can cause serious diseases such as
cirrhosis and hepatocellular cancer (HCC). We aimed to evaluate retrospectively
220 liver biopsy proven patients with NAFLD in this study. A total of 220 patients diagnosed with NAFLD
by liver biopsy followed in the gastroenterology outpatient clinic of Demiroğlu
Bilim University Faculty of Medicine between 2010-2019 were included in the
study. Demographic data (age, gender, height, weight and body mass index),
biochemical laboratory parameters and biopsy results were scanned and recorded
retrospectively from hospital information system and files of patients. The mean age of the patients was 34.14 ± 6.72
and 60% of the patients were male and 40% were female. Mean liver steatosis
percentage was similar in male and female patients (p: 0.41). The mean BMI of
the patients was 27.32 ± 3.02, the mean liver steatosis percentage was 12.1 ±
8.68% and the mean Homeostatic Model of Assessment-Insulin Resistance (HOMA-IR)
value was 2.64. There was a positive correlation between liver steatosis and
BMI, aspartate aminotransferase, alanine aminotransferase, alkaline
phosphatase, gamaglutamyl transferase, total cholesterol, triglyceride,
creatinine and HOMA-IR, but no correlation was found between liver steatosis
and age, urea and bilirubin. In our study, it was observed that NAFLD can be
seen in young and middle-aged, non-obese individuals, and BMI and insulin
resistance may be associated with NAFLD in this patient group. In addition,
liver enzymes were found to be associated with NAFLD even if they were in the
normal range. More reliable data can be obtained with new and more extensive
studies.

Keywords

Liver steatosis, NAFLD, hepatosteatosis

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