Influence of fabrication temperature on the structural features of chitosan gels for tissue engineering applications

Year 2019, Volume: 3 Issue: 3, 170 - 174, 15.12.2019

Nimet Bölgen , Seda Ceylan Didem Demir

https://doi.org/10.35860/iarej.475136

Cited By: 2

Abstract

Chitosan is a natural polymer
synthesized from the chitin of crab, lobster shells, fungal mycelia and shrimp.
It has been used for biomedical applications in many different structures
including thin film, nanofibrous membrane, sponge, microsphere, hydrogel and
cryogel because of its non-toxicity, biodegradability, biocompatibility and
antibacterial properties. Cryogelation technique is based on the crosslinking
of polymers or crosslinking polymerization of monomers in the presence of
crosslinking agents at temperatures below zero. On the other hand, hydrogels
are mainly prepared at room temperature. In this study, chitosan gels were
prepared at different reaction temperatures (-25, 0 and +25°C). Swelling
profiles revealed that with decreasing reaction temperature swelling ratio
increased. In addition, the degradation rate of chitosan gels prepared at -25
and +25°C was measured 50.60 and 30.88%, respectively. Results indicate that
reaction temperature affects the architecture and characterization results of
the gels. 

Keywords

Chitosan, Cryogel, Hydrogel, Scaffold, Tissue Engineering

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