The effects of subacute deltamethrin exposure on rat liver: histochemical, immunohistochemical, and biochemical study

Year 2016, Volume: 2 Issue: 2, 130 - 137, 01.06.2016

Türker Çavuşoğlu Muhammet Fatih Aydın Eylem Çağıltay Gürkan Yiğittürk İlker Kızıloğlu Ayfer Meral Kubilay Doğan Kılıç Yiğit Uyanıkgil Emel Öykü Çetin Uyanıkgil Oytun Erbaş

Abstract

Objectives: This study aims to determine deltamethrin’s effects on early diagnosis of toxicity and liver toxicity markers in an animal model.

Materials and methods: A total of 36 male rats weighing 200-220 gram were separated into four groups. Group 1 rats were given deltamethrin15 mg/kg/day, group 2 rats were given deltamethrin 30 mg/kg/day, group 3 rats were given deltamethrin 60 mg/kg/day, and group 4 rats (controlgroup) were given 0.9% sodium chloride 1 mL/kg/day for 30 days by oral gavage.

Results: Deltamethrin ingestion resulted in edema, nuclear hypertrophy, and parenchymal and stromal inflammation on the histopathologicalexamination. Malondialdehyde levels increased and glutathione levels decreased when compared with the control group as the treatment doseincreased. Alanine transaminase levels increased significantly when compared with the control group. The changes correlated directly with increasingdose.

Conclusion: Deltamethrin usage causes liver toxicity in a dose dependent manner on rats. This toxicity is observed both biochemically andhistopathologically. Liver biomarkers and oxidative stress parameters can effectively be used for potential toxicity monitorization.

Keywords

Deltamethrin, liver, rat, subacute toxicity