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Oksitosinin hücresel tedavide kullanılma potansiyeli

Year 2015, Volume: 1 Issue: 3, 163 - 169, 07.12.2015

Gözde Sır Esra Arısu Gürkan Yiğittürk Türker Çavuşoğlu Çığır Biray Avcı Servet Çelik Oytun Erbaş , Yiğit Uyanıkgil

Abstract

Oksitosin dokuz aminoasitten oluşan bir memeli peptit hormonudur. Hipotalamusun supraoptik ve paraventriküler çekirdeklerinden sentezlenir ve beyinde nöromodülatör olarak görev alır. Bu nörotransmitterin doğum sırasında, sonrasında ve üremede önemli görevleri vardır. Uterus kaslarının kasılmasını uyararak doğumu kolaylaştırır. Aynı zamanda doğum süresince beyni hipoksiden koruyucu etkisi vardır. Oksitoksin dişilerde menstrüel siklusun düzenlenmesini sağlarken erkek genital sisteminde ejakulasyonda görev yapar. Oksitoksin otizm gibi sosyal etkileşim ve iletişime zarar veren hastalıklarda tekrarlayan davranışları azaltmaktadır. Günümüzde otoksin tedavisi ve hücresel çalışmalar popülarite kazanmıştır. Oksitosin meme kanseri ve diğer tümör hücrelerinin çoğalmasını engellemektedir. Oksitoksin kök hücrelerin kardiyomiyosit oluşumunu ve farklılaşmayı düzenler. Oksitoksin kalpte apoptozu önleyici etki göstermektedir. Oksitoksin kök hücreler ile birlikte inflamasyonu azaltır. Anjiyogenezi uyarır ve iskemi-reperfüzyon hasarında kardiyak onarımı sağlar. Oksitosin tedavilerin avantajı, hücre üretimini organizmanın kendi kendine gerçekleştirmesinin sağlanması ve hiçbir yan etkisinin görülmemesidir.

Keywords

Apoptoz oksitosin rejenerasyon kök hücre

References

  • Hansen JT. Head and Neck Frank Netter Atlas of Human Anatomy. Section 1, 5th ed. Philadelphia: Elsevier; 2011. p. 145-6.
  • Standring S. Diencephalon. Gray’s Anatomy the Anatomical Basis of Clinical Practice. Chapter 21, 40th ed. London: Churchill Livingstone Elsevier; 2008. p. 319-23.
  • FitzGerald MJT, Gruener G, Mtui E. Hypothalamus. Clinical Neuroanatomy and Neuroscience. Chapter 26, 6th ed. London: Saunders Elsevier; 2012. p. 278-83.
  • Kabilan A. Pharmacological role of oxytocin-a short review. Pharm Sci & Res 2014;6:220-3.
  • Gainer H, Altstein M, Whitnall M, Wray S. The biosynthesis and secretion of oxytocin and vasopressin. In: Knobil E, Neill J, editors. The Physiology of Reproduction. New York: Raven Press; 1988. p. 2265-81.
  • Du Vigneaud V. Trail of sulfur research: from insulin to oxytocin. Science 1956;123:967-74.
  • Uzun M, Sulu N. Oksitosin ve fizyolojik etkileri. Kafkas Uni Vet Fak Derg 2002;8:91-7.
  • Erba O. Oksitosinin fizyolojik etkileri ve klinik uygulama alanları. Izm Univ Med J 2013;1:43-53.
  • Khazipov R, Tyzio R, Ben-Ari Y. Effects of oxytocin on GABA signalling in the foetal brain during delivery. Prog Brain Res 2008;170:243-57.
  • Young KA, Gobrogge KL, Liu Y, Wang Z. The neurobiology of pair bonding: insights from a socially monogamous rodent. Front Neuroendocrinol 2011;32:53-69.
  • Neumann ID, Krömer SA, Toschi N, Ebner K. Brain oxytocin inhibits the (re)activity of the hypothalamo- pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions. Regul Pept
  • Neumann ID, Wigger A, Torner L, Holsboer F, Landgraf R. Brain oxytocin inhibits basal and stress- induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus. J Neuroendocrinol 2000;12:235-43.
  • Neumann ID. Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo- pituitary-adrenal axis. Prog Brain Res 2002;139:147-62.
  • Huber D, Veinante P, Stoop R. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 2005;308:245-8.
  • Burbach JP, Young LJ, Russell J. Oxytocin: synthesis, secretion, and reproductive functions. In: Neill JD, editor. Knobil and Neill’s Physiology of Reproduction. New York: Elsevier; 2006. p. 3055-127.
  • Frith U. Mind blindness and the brain in autism. Neuron 2001;32:969-79.
  • Modahl C, Green L, Fein D, Morris M, Waterhouse L, Feinstein C, et al. Plasma oxytocin levels in autistic children. Biol Psychiatry 1998;43:270-7.
  • Hollander E, Novotny S, Hanratty M, Yaffe R, DeCaria CM, Aronowitz BR, et al. Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders. Neuropsychopharmacology 2003;28:193-8.
  • Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L, et al. Oxytocin increases retention of social cognition in autism. Biol Psychiatry 2007;61:498-503.
  • Blevins JE, Baskin DG. Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans. Physiol Behav 2015;31-9384.
  • Neumann ID, Landgraf R. Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci 2012;35:649-59.
  • Kanwal JS, Rao PD. Oxytocin within auditory nuclei: a neuromodulatory function in sensory processing? Neuroreport 2002;13:2193-7.
  • Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G. Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A. Int J Cancer 1997;72:340-4.
  • Cassoni P, Sapino A, Stella A, Fortunati N, Bussolati G. Presence and significance of oxytocin receptors in human neuroblastomas and glial tumors. Int J Cancer 1998;77:695-700.
  • Copland JA, Ives KL, Simmons DJ, Soloff MS. Functional oxytocin receptors discovered in human osteoblasts. Endocrinology 1999;140:4371-4.
  • Martens H, Kecha O, Charlet-Renard C, Defresne MP, Geenen V. Neurohypophysial peptides stimulate the phosphorylation of pre-T cell focal adhesion kinases. Neuroendocrinology 1998;67:282-9.
  • Cassoni P, Sapino A, Munaron L, Deaglio S, Chini B, Graziani A, et al. Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines. Endocrinology 2001;142:1130-6.
  • Sapino A, Macrì L, Tonda L, Bussolati G. Oxytocin enhances myoepithelial cell differentiation and proliferation in the mouse mammary gland. Endocrinology 1993;133:838-42.
  • Paquin J, Danalache BA, Jankowski M, McCann SM, Gutkowska J. Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes. Proc Natl Acad Sci U S A 2002;99:9550-5.
  • Jankowski M, Danalache B, Wang D, Bhat P, Hajjar F. Marcinkiewicz, et al. Oxytocin in cardiac ontogeny. Proc Natl Acad Sci USA 2004; 101: 13074-13079.
  • Soares TJ, Coimbra TM, Martins AR, Pereira AG, Carnio EC, Branco LG, et al. Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP. Proc Natl Acad Sci U S A 1999;96:278-83.
  • Favaretto AL, Ballejo GO, Albuquerque-Araşjo WI, Gutkowska J, Antunes-Rodrigues J, McCann SM. Oxytocin releases atrial natriuretic peptide from rat atria in vitro that exerts negative inotropic and chronotropic action. Peptides 1997;18:1377-81.
  • Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, et al. Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol 2007;176:329-41.
  • Matsuura K, Nagai T, Nishigaki N, Oyama T, Nishi J, Wada H, et al. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem 2004;279:11384-91.
  • Ybarra N, Vincent P, Smith LC, Troncy E. Oxytocin improves the expression of cardiac specific markers in porcine bone marrow stem cells differentiation. Res Vet Sci 2015;98:42-50.
  • Kim YS, Ahn Y, Kwon JS, Cho YK, Jeong MH, Cho JG, et al. Priming of mesenchymal stem cells with oxytocin enhances the cardiac repair in ischemia/reperfusion injury. Cells Tissues Organs 2012;195:428-42.
  • Gutkowska J, Jankowski M, Antunes-Rodrigues J. The role of oxytocin in cardiovascular regulation. Braz J Med Biol Res 2014;47:206-14.
  • Noiseux N, Borie M, Desnoyers A, Menaouar A, Stevens LM, Mansour S, et al. Preconditioning of stem cells by oxytocin to improve their therapeutic potential. Endocrinology 2012;153:5361-72.
  • Szeto A, Nation DA, Mendez AJ, Dominguez-Bendala J, Brooks LG, Schneiderman N, et al. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. Am J Physiol Endocrinol Metab 2008;295:1495-501.
  • Leuner B, Caponiti JM, Gould E. Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids. Hippocampus
  • Elabd C, Cousin W, Upadhyayula P, Chen RY, Chooljian MS, Li J, et al. Oxytocin is an age- specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat Commun 2014;5:4082.
  • Elabd C, Basillais A, Beaupied H, Breuil V, Wagner N, Scheideler M, et al. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells 2008;26:2399-407.
  • Raymond AD, Kucherepa NN, Fisher KR, Halina WG, Partlow GD. Neurogenesis of oxytocin- containing neurons in the paraventricular nucleus (PVN) of the female pig in 3 reproductive states: puberty gilts, adult gilts and lactating sows. Brain Res 2006;1102:44-51.
  • Jafarzadeh N, Javeri A, Khaleghi M, Taha MF. Oxytocin improves proliferation and neural differentiation of adipose tissue-derived stem cells. Neurosci Lett 2014;564:105-10.
  • Fadini GP, Sartore S, Schiavon M, Albiero M, Baesso I, Cabrelle A, et al. Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats. Diabetologia 2006;49:3075-84.
  • Fadini GP, Albiero M, Seeger F, Poncina N, Menegazzo L, Angelini A, et al. Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy. Basic Res Cardiol 2013;108:313.
  • Kim YS, Kwon JS, Hong MH, Kang WS, Jeong HY, Kang HJ, et al. Restoration of angiogenic capacity of diabetes-insulted mesenchymal stem cells by oxytocin. BMC Cell Biol 2013;14:38.
  • Esin A, Esra CD, Ahmet Özer S, ermin T, Rabia P, Göksel S, et al. The effect of oxytocin on the urinary bladder in male rats exposed to water avoidance stress: Light and electron microscopic investigation. Marmara Pharmaceutical Journal 2015; 19: 19-26.
  • Erkanli Senturk G, Erkanli K, Aydin U, Yucel D, Isiksacan N, Ercan F, et al. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides 2013;40:82-8.

Year 2015, Volume: 1 Issue: 3, 163 - 169, 07.12.2015

Gözde Sır Esra Arısu Gürkan Yiğittürk Türker Çavuşoğlu Çığır Biray Avcı Servet Çelik Oytun Erbaş , Yiğit Uyanıkgil

Abstract

References

  • Hansen JT. Head and Neck Frank Netter Atlas of Human Anatomy. Section 1, 5th ed. Philadelphia: Elsevier; 2011. p. 145-6.
  • Standring S. Diencephalon. Gray’s Anatomy the Anatomical Basis of Clinical Practice. Chapter 21, 40th ed. London: Churchill Livingstone Elsevier; 2008. p. 319-23.
  • FitzGerald MJT, Gruener G, Mtui E. Hypothalamus. Clinical Neuroanatomy and Neuroscience. Chapter 26, 6th ed. London: Saunders Elsevier; 2012. p. 278-83.
  • Kabilan A. Pharmacological role of oxytocin-a short review. Pharm Sci & Res 2014;6:220-3.
  • Gainer H, Altstein M, Whitnall M, Wray S. The biosynthesis and secretion of oxytocin and vasopressin. In: Knobil E, Neill J, editors. The Physiology of Reproduction. New York: Raven Press; 1988. p. 2265-81.
  • Du Vigneaud V. Trail of sulfur research: from insulin to oxytocin. Science 1956;123:967-74.
  • Uzun M, Sulu N. Oksitosin ve fizyolojik etkileri. Kafkas Uni Vet Fak Derg 2002;8:91-7.
  • Erba O. Oksitosinin fizyolojik etkileri ve klinik uygulama alanları. Izm Univ Med J 2013;1:43-53.
  • Khazipov R, Tyzio R, Ben-Ari Y. Effects of oxytocin on GABA signalling in the foetal brain during delivery. Prog Brain Res 2008;170:243-57.
  • Young KA, Gobrogge KL, Liu Y, Wang Z. The neurobiology of pair bonding: insights from a socially monogamous rodent. Front Neuroendocrinol 2011;32:53-69.
  • Neumann ID, Krömer SA, Toschi N, Ebner K. Brain oxytocin inhibits the (re)activity of the hypothalamo- pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions. Regul Pept
  • Neumann ID, Wigger A, Torner L, Holsboer F, Landgraf R. Brain oxytocin inhibits basal and stress- induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus. J Neuroendocrinol 2000;12:235-43.
  • Neumann ID. Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo- pituitary-adrenal axis. Prog Brain Res 2002;139:147-62.
  • Huber D, Veinante P, Stoop R. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 2005;308:245-8.
  • Burbach JP, Young LJ, Russell J. Oxytocin: synthesis, secretion, and reproductive functions. In: Neill JD, editor. Knobil and Neill’s Physiology of Reproduction. New York: Elsevier; 2006. p. 3055-127.
  • Frith U. Mind blindness and the brain in autism. Neuron 2001;32:969-79.
  • Modahl C, Green L, Fein D, Morris M, Waterhouse L, Feinstein C, et al. Plasma oxytocin levels in autistic children. Biol Psychiatry 1998;43:270-7.
  • Hollander E, Novotny S, Hanratty M, Yaffe R, DeCaria CM, Aronowitz BR, et al. Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders. Neuropsychopharmacology 2003;28:193-8.
  • Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L, et al. Oxytocin increases retention of social cognition in autism. Biol Psychiatry 2007;61:498-503.
  • Blevins JE, Baskin DG. Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans. Physiol Behav 2015;31-9384.
  • Neumann ID, Landgraf R. Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci 2012;35:649-59.
  • Kanwal JS, Rao PD. Oxytocin within auditory nuclei: a neuromodulatory function in sensory processing? Neuroreport 2002;13:2193-7.
  • Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G. Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A. Int J Cancer 1997;72:340-4.
  • Cassoni P, Sapino A, Stella A, Fortunati N, Bussolati G. Presence and significance of oxytocin receptors in human neuroblastomas and glial tumors. Int J Cancer 1998;77:695-700.
  • Copland JA, Ives KL, Simmons DJ, Soloff MS. Functional oxytocin receptors discovered in human osteoblasts. Endocrinology 1999;140:4371-4.
  • Martens H, Kecha O, Charlet-Renard C, Defresne MP, Geenen V. Neurohypophysial peptides stimulate the phosphorylation of pre-T cell focal adhesion kinases. Neuroendocrinology 1998;67:282-9.
  • Cassoni P, Sapino A, Munaron L, Deaglio S, Chini B, Graziani A, et al. Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines. Endocrinology 2001;142:1130-6.
  • Sapino A, Macrì L, Tonda L, Bussolati G. Oxytocin enhances myoepithelial cell differentiation and proliferation in the mouse mammary gland. Endocrinology 1993;133:838-42.
  • Paquin J, Danalache BA, Jankowski M, McCann SM, Gutkowska J. Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes. Proc Natl Acad Sci U S A 2002;99:9550-5.
  • Jankowski M, Danalache B, Wang D, Bhat P, Hajjar F. Marcinkiewicz, et al. Oxytocin in cardiac ontogeny. Proc Natl Acad Sci USA 2004; 101: 13074-13079.
  • Soares TJ, Coimbra TM, Martins AR, Pereira AG, Carnio EC, Branco LG, et al. Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP. Proc Natl Acad Sci U S A 1999;96:278-83.
  • Favaretto AL, Ballejo GO, Albuquerque-Araşjo WI, Gutkowska J, Antunes-Rodrigues J, McCann SM. Oxytocin releases atrial natriuretic peptide from rat atria in vitro that exerts negative inotropic and chronotropic action. Peptides 1997;18:1377-81.
  • Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, et al. Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol 2007;176:329-41.
  • Matsuura K, Nagai T, Nishigaki N, Oyama T, Nishi J, Wada H, et al. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem 2004;279:11384-91.
  • Ybarra N, Vincent P, Smith LC, Troncy E. Oxytocin improves the expression of cardiac specific markers in porcine bone marrow stem cells differentiation. Res Vet Sci 2015;98:42-50.
  • Kim YS, Ahn Y, Kwon JS, Cho YK, Jeong MH, Cho JG, et al. Priming of mesenchymal stem cells with oxytocin enhances the cardiac repair in ischemia/reperfusion injury. Cells Tissues Organs 2012;195:428-42.
  • Gutkowska J, Jankowski M, Antunes-Rodrigues J. The role of oxytocin in cardiovascular regulation. Braz J Med Biol Res 2014;47:206-14.
  • Noiseux N, Borie M, Desnoyers A, Menaouar A, Stevens LM, Mansour S, et al. Preconditioning of stem cells by oxytocin to improve their therapeutic potential. Endocrinology 2012;153:5361-72.
  • Szeto A, Nation DA, Mendez AJ, Dominguez-Bendala J, Brooks LG, Schneiderman N, et al. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. Am J Physiol Endocrinol Metab 2008;295:1495-501.
  • Leuner B, Caponiti JM, Gould E. Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids. Hippocampus
  • Elabd C, Cousin W, Upadhyayula P, Chen RY, Chooljian MS, Li J, et al. Oxytocin is an age- specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat Commun 2014;5:4082.
  • Elabd C, Basillais A, Beaupied H, Breuil V, Wagner N, Scheideler M, et al. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells 2008;26:2399-407.
  • Raymond AD, Kucherepa NN, Fisher KR, Halina WG, Partlow GD. Neurogenesis of oxytocin- containing neurons in the paraventricular nucleus (PVN) of the female pig in 3 reproductive states: puberty gilts, adult gilts and lactating sows. Brain Res 2006;1102:44-51.
  • Jafarzadeh N, Javeri A, Khaleghi M, Taha MF. Oxytocin improves proliferation and neural differentiation of adipose tissue-derived stem cells. Neurosci Lett 2014;564:105-10.
  • Fadini GP, Sartore S, Schiavon M, Albiero M, Baesso I, Cabrelle A, et al. Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats. Diabetologia 2006;49:3075-84.
  • Fadini GP, Albiero M, Seeger F, Poncina N, Menegazzo L, Angelini A, et al. Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy. Basic Res Cardiol 2013;108:313.
  • Kim YS, Kwon JS, Hong MH, Kang WS, Jeong HY, Kang HJ, et al. Restoration of angiogenic capacity of diabetes-insulted mesenchymal stem cells by oxytocin. BMC Cell Biol 2013;14:38.
  • Esin A, Esra CD, Ahmet Özer S, ermin T, Rabia P, Göksel S, et al. The effect of oxytocin on the urinary bladder in male rats exposed to water avoidance stress: Light and electron microscopic investigation. Marmara Pharmaceutical Journal 2015; 19: 19-26.
  • Erkanli Senturk G, Erkanli K, Aydin U, Yucel D, Isiksacan N, Ercan F, et al. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides 2013;40:82-8.
There are 49 citations in total.

Details

Primary Language Turkish
Journal Section Review
Authors

Gözde Sır This is me

Esra Arısu This is me

Gürkan Yiğittürk This is me

Türker Çavuşoğlu This is me

Çığır Biray Avcı This is me

Servet Çelik This is me

Oytun Erbaş

Yiğit Uyanıkgil

Publication Date December 7, 2015
Published in Issue Year 2015 Volume: 1 Issue: 3

Cite

APA Sır, G., Arısu, E., Yiğittürk, G., Çavuşoğlu, T., et al. (2015). Oksitosinin hücresel tedavide kullanılma potansiyeli. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 1(3), 163-169. https://doi.org/10.5606/fng.btd.2015.030
AMA Sır G, Arısu E, Yiğittürk G, Çavuşoğlu T, Avcı ÇB, Çelik S, Erbaş O, Uyanıkgil Y. Oksitosinin hücresel tedavide kullanılma potansiyeli. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. December 2015;1(3):163-169. doi:10.5606/fng.btd.2015.030
Chicago Sır, Gözde, Esra Arısu, Gürkan Yiğittürk, Türker Çavuşoğlu, Çığır Biray Avcı, Servet Çelik, Oytun Erbaş, and Yiğit Uyanıkgil. “Oksitosinin hücresel Tedavide kullanılma Potansiyeli”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1, no. 3 (December 2015): 163-69. https://doi.org/10.5606/fng.btd.2015.030.
EndNote Sır G, Arısu E, Yiğittürk G, Çavuşoğlu T, Avcı ÇB, Çelik S, Erbaş O, Uyanıkgil Y (December 1, 2015) Oksitosinin hücresel tedavide kullanılma potansiyeli. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1 3 163–169.
IEEE G. Sır, E. Arısu, G. Yiğittürk, T. Çavuşoğlu, Ç. B. Avcı, S. Çelik, O. Erbaş, and Y. Uyanıkgil, “Oksitosinin hücresel tedavide kullanılma potansiyeli”, İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, vol. 1, no. 3, pp. 163–169, 2015, doi: 10.5606/fng.btd.2015.030.
ISNAD Sır, Gözde et al. “Oksitosinin hücresel Tedavide kullanılma Potansiyeli”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1/3 (December 2015), 163-169. https://doi.org/10.5606/fng.btd.2015.030.
JAMA Sır G, Arısu E, Yiğittürk G, Çavuşoğlu T, Avcı ÇB, Çelik S, Erbaş O, Uyanıkgil Y. Oksitosinin hücresel tedavide kullanılma potansiyeli. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2015;1:163–169.
MLA Sır, Gözde et al. “Oksitosinin hücresel Tedavide kullanılma Potansiyeli”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, vol. 1, no. 3, 2015, pp. 163-9, doi:10.5606/fng.btd.2015.030.
Vancouver Sır G, Arısu E, Yiğittürk G, Çavuşoğlu T, Avcı ÇB, Çelik S, Erbaş O, Uyanıkgil Y. Oksitosinin hücresel tedavide kullanılma potansiyeli. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2015;1(3):163-9.
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