Synthesis and Characterization of Metal Carbonyls [M(CO)6 (M= Cr, Mo,W), Re(CO)5Br] with Indole -3-carboxyaldehydemethanesulfonylhydrazone

Year 2018, , 31 - 34, 29.12.2018

Sema Sert

https://doi.org/10.38061/idunas.444281

Abstract

Abstract

Four new
complexes, M(CO)₅(inmsh) (M=Cr(1), Mo(2),W(3)) and Re(CO)₄Br(inmsh)
(4), were synthesized by the photochemical reaction of metal carbonyls with
indole-3-carboxyaldehydemethanesulfonyl hydrazone(inmsh) and characterized by
using elemental analysis, ¹H NMR, LC-MS and IR spectra. The
spectroscopic studies show that inmsh behaves as a monodantate ligand
coordinating via imine N donor atom in [M(CO)₅(inmsh)] (M=Cr, Mo, W)
and Re(CO)₄Br(inmsh).

Keywords

Sulfonylhydrazones, Metal Carbonyls

Synthesis and Characterization of Metal Carbonyls [M(CO)6(M = Cr,Mo,W)] with Indole -3-carboxyaldehydemethanesulfonylhydrazone

Abstract

Four new complexes, [M(CO)5(msh4)](Cr(1),Mo(2),W(3)),and Re(CO)4Br(inmsh)(4),were synthesized by the photochemical reaction of metal carbonyls with indole-3 carboxyaldehydemethanesulfonyl hydrazone(inmsh) and characterized by using elemental analysis, 1H NMR, EI-MS and IR spectra. The spectroscopic studies show that
inmsh behaves as a monodantate ligand coordinating via imine N donor atom in [M(CO)5(inmsh)](M = Cr,Mo,W) and Re(CO)4Br(inmsh). The sulfonamides (−SO2NH−) are used widely as antibacterial agents because of their lower cost, lower activity and most activity against bacterial diseases[1]. Sulfo drugs are used as chemotherapeutic agents with large spectrum of activity and they are used today for various bacterial, protozoal and fungal infections[2a,b]. Methane sulfonamide derivatives possess DNA-binding ability and show cytostatic effects which have usage in cancer chemotherapy. Sulfonylhydrazones derived from sulfonamides have pharmacological properties as antibacterial, antitumor, divretic, antiviral, antinociceptive activity and enzym inhibition especially to carbonic anhydrase species[3,4]. Many of the physiologically active hydrazones have applications in the treatment of illness like tuberculosis, leprosy and mental damage

Keywords

Metal Carbonyls, Sulfonylhydrazones, Photochemical Reactions

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